Insulin Resistance, a Link between Maternal Overweight and Fetal Macrosomia in Nondiabetic Pregnancies
Background/Aims: During the last decades the number of large for gestational age infants delivered by nondiabetic mothers has increased. Our aim was to investigate to what extent fetal growth in nondiabetic pregnant women can be explained by rates of maternal energy substrate production and resting...
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| Veröffentlicht in: | Hormone research in paediatrics 2010-01, Vol.74 (4), p.267-274 |
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| creator | Ahlsson, Fredrik Diderholm, Barbro Jonsson, Björn Nordén-Lindberg, Solvig Olsson, Roger Ewald, Uwe Forslund, Anders Stridsberg, Mats Gustafsson, Jan |
| description | Background/Aims: During the last decades the number of large for gestational age infants delivered by nondiabetic mothers has increased. Our aim was to investigate to what extent fetal growth in nondiabetic pregnant women can be explained by rates of maternal energy substrate production and resting energy expenditure. Methods: Twenty nonsmoking pregnant women without impaired glucose tolerance and with a wide range of fetal weights (0.2–2.7 SDS) were investigated at 36 weeks of gestation. Maternal lipolysis, glucose production, resting energy expenditure, body composition and insulin resistance were assessed.Results: Median (range) glucose production rate was 805 (653–1,337) µmol/min and that of glycerol, reflecting lipolysis, was 214 (110–576) µmol/min. Multiple linear regression analysis showed that maternal fat mass explained 36% of the variation in insulin resistance, accounting for 62% of the variation in glucose production. Further, glucose production explained 31% of the variation in fetal weight. Resting energy expenditure explained 51% of the variation in estimated fetal weight. Conclusion: Fetal weight is dependent on maternal glucose production, which is in turn determined by the degree of insulin resistance, induced in part by the maternal fat mass. The variation in maternal resting energy expenditure is closely related to fetal weight. |
| doi_str_mv | 10.1159/000295710 |
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Our aim was to investigate to what extent fetal growth in nondiabetic pregnant women can be explained by rates of maternal energy substrate production and resting energy expenditure. Methods: Twenty nonsmoking pregnant women without impaired glucose tolerance and with a wide range of fetal weights (0.2–2.7 SDS) were investigated at 36 weeks of gestation. Maternal lipolysis, glucose production, resting energy expenditure, body composition and insulin resistance were assessed.Results: Median (range) glucose production rate was 805 (653–1,337) µmol/min and that of glycerol, reflecting lipolysis, was 214 (110–576) µmol/min. Multiple linear regression analysis showed that maternal fat mass explained 36% of the variation in insulin resistance, accounting for 62% of the variation in glucose production. Further, glucose production explained 31% of the variation in fetal weight. Resting energy expenditure explained 51% of the variation in estimated fetal weight. Conclusion: Fetal weight is dependent on maternal glucose production, which is in turn determined by the degree of insulin resistance, induced in part by the maternal fat mass. The variation in maternal resting energy expenditure is closely related to fetal weight.</description><identifier>ISSN: 1663-2818</identifier><identifier>EISSN: 1663-2826</identifier><identifier>DOI: 10.1159/000295710</identifier><identifier>PMID: 20431277</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adiposity ; Adult ; Basal Metabolism ; Body Composition ; Body Mass Index ; Female ; Fetal Macrosomia - epidemiology ; Fetal Weight ; Gluconeogenesis ; Humans ; Infant, Newborn ; Insulin Resistance ; Large for gestational age infants ; Lipolysis ; MEDICIN ; MEDICINE ; Original Paper ; Overweight - physiopathology ; Pregnancy ; Pregnancy Trimester, Third ; Ultrasonography, Prenatal</subject><ispartof>Hormone research in paediatrics, 2010-01, Vol.74 (4), p.267-274</ispartof><rights>2010 S. Karger AG, Basel</rights><rights>Copyright © 2010 S. Karger AG, Basel.</rights><rights>Copyright (c) 2010 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-56c096f519a02be67bf8dc3f17a123e6d9949dd917483fbcb15c718460e2ed423</citedby><cites>FETCH-LOGICAL-c370t-56c096f519a02be67bf8dc3f17a123e6d9949dd917483fbcb15c718460e2ed423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,2427,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20431277$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-124332$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahlsson, Fredrik</creatorcontrib><creatorcontrib>Diderholm, Barbro</creatorcontrib><creatorcontrib>Jonsson, Björn</creatorcontrib><creatorcontrib>Nordén-Lindberg, Solvig</creatorcontrib><creatorcontrib>Olsson, Roger</creatorcontrib><creatorcontrib>Ewald, Uwe</creatorcontrib><creatorcontrib>Forslund, Anders</creatorcontrib><creatorcontrib>Stridsberg, Mats</creatorcontrib><creatorcontrib>Gustafsson, Jan</creatorcontrib><title>Insulin Resistance, a Link between Maternal Overweight and Fetal Macrosomia in Nondiabetic Pregnancies</title><title>Hormone research in paediatrics</title><addtitle>Horm Res Paediatr</addtitle><description>Background/Aims: During the last decades the number of large for gestational age infants delivered by nondiabetic mothers has increased. Our aim was to investigate to what extent fetal growth in nondiabetic pregnant women can be explained by rates of maternal energy substrate production and resting energy expenditure. Methods: Twenty nonsmoking pregnant women without impaired glucose tolerance and with a wide range of fetal weights (0.2–2.7 SDS) were investigated at 36 weeks of gestation. Maternal lipolysis, glucose production, resting energy expenditure, body composition and insulin resistance were assessed.Results: Median (range) glucose production rate was 805 (653–1,337) µmol/min and that of glycerol, reflecting lipolysis, was 214 (110–576) µmol/min. Multiple linear regression analysis showed that maternal fat mass explained 36% of the variation in insulin resistance, accounting for 62% of the variation in glucose production. Further, glucose production explained 31% of the variation in fetal weight. Resting energy expenditure explained 51% of the variation in estimated fetal weight. Conclusion: Fetal weight is dependent on maternal glucose production, which is in turn determined by the degree of insulin resistance, induced in part by the maternal fat mass. The variation in maternal resting energy expenditure is closely related to fetal weight.</description><subject>Adiposity</subject><subject>Adult</subject><subject>Basal Metabolism</subject><subject>Body Composition</subject><subject>Body Mass Index</subject><subject>Female</subject><subject>Fetal Macrosomia - epidemiology</subject><subject>Fetal Weight</subject><subject>Gluconeogenesis</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Insulin Resistance</subject><subject>Large for gestational age infants</subject><subject>Lipolysis</subject><subject>MEDICIN</subject><subject>MEDICINE</subject><subject>Original Paper</subject><subject>Overweight - physiopathology</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, Third</subject><subject>Ultrasonography, Prenatal</subject><issn>1663-2818</issn><issn>1663-2826</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpd0VFLHDEQB_AgLSrWB9-lBPogBa_NJLvJ5lG0VuGspVRfQzY7e43uZc9kt0e_fXOsnuBTQvjNn8wMIUfAvgCU-itjjOtSAdsh-yClmPGKy3fbO1R75DClh8yYqJQGtUv2OCsEcKX2SXsd0tj5QH9h8mmwweEptXTuwyOtcVgjBnpjB4zBdvT2L8Y1-sWfgdrQ0Esc8uONdbFP_dJbmmN-9KHxNld6R39GXISc6DF9IO9b2yU8fD4PyN3lt9_nV7P57ffr87P5zAnFhlkpHdOyLUFbxmuUqm6rxokWlAUuUDZaF7ppchNFJdra1VA6BVUhGXJsCi4OyOmUm9a4Gmuzin5p4z_TW28u_P2Z6ePCjKMBXgix4ScTX8X-acQ0mKVPDrvOBuzHZFSplC6Z0ll-eiMf-nEzlGSAVSCzkkVWnye1GUmK2G4_AMxstmW228r243PiWC-x2cqX3WRwPIFHGxcYX8FU_x89ypbY</recordid><startdate>20100101</startdate><enddate>20100101</enddate><creator>Ahlsson, Fredrik</creator><creator>Diderholm, Barbro</creator><creator>Jonsson, Björn</creator><creator>Nordén-Lindberg, Solvig</creator><creator>Olsson, Roger</creator><creator>Ewald, Uwe</creator><creator>Forslund, Anders</creator><creator>Stridsberg, Mats</creator><creator>Gustafsson, Jan</creator><general>S. Karger AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>DF2</scope></search><sort><creationdate>20100101</creationdate><title>Insulin Resistance, a Link between Maternal Overweight and Fetal Macrosomia in Nondiabetic Pregnancies</title><author>Ahlsson, Fredrik ; Diderholm, Barbro ; Jonsson, Björn ; Nordén-Lindberg, Solvig ; Olsson, Roger ; Ewald, Uwe ; Forslund, Anders ; Stridsberg, Mats ; Gustafsson, Jan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-56c096f519a02be67bf8dc3f17a123e6d9949dd917483fbcb15c718460e2ed423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adiposity</topic><topic>Adult</topic><topic>Basal Metabolism</topic><topic>Body Composition</topic><topic>Body Mass Index</topic><topic>Female</topic><topic>Fetal Macrosomia - epidemiology</topic><topic>Fetal Weight</topic><topic>Gluconeogenesis</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Insulin Resistance</topic><topic>Large for gestational age infants</topic><topic>Lipolysis</topic><topic>MEDICIN</topic><topic>MEDICINE</topic><topic>Original Paper</topic><topic>Overweight - physiopathology</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, Third</topic><topic>Ultrasonography, Prenatal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahlsson, Fredrik</creatorcontrib><creatorcontrib>Diderholm, Barbro</creatorcontrib><creatorcontrib>Jonsson, Björn</creatorcontrib><creatorcontrib>Nordén-Lindberg, Solvig</creatorcontrib><creatorcontrib>Olsson, Roger</creatorcontrib><creatorcontrib>Ewald, Uwe</creatorcontrib><creatorcontrib>Forslund, Anders</creatorcontrib><creatorcontrib>Stridsberg, Mats</creatorcontrib><creatorcontrib>Gustafsson, Jan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Uppsala universitet</collection><jtitle>Hormone research in paediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahlsson, Fredrik</au><au>Diderholm, Barbro</au><au>Jonsson, Björn</au><au>Nordén-Lindberg, Solvig</au><au>Olsson, Roger</au><au>Ewald, Uwe</au><au>Forslund, Anders</au><au>Stridsberg, Mats</au><au>Gustafsson, Jan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insulin Resistance, a Link between Maternal Overweight and Fetal Macrosomia in Nondiabetic Pregnancies</atitle><jtitle>Hormone research in paediatrics</jtitle><addtitle>Horm Res Paediatr</addtitle><date>2010-01-01</date><risdate>2010</risdate><volume>74</volume><issue>4</issue><spage>267</spage><epage>274</epage><pages>267-274</pages><issn>1663-2818</issn><eissn>1663-2826</eissn><abstract>Background/Aims: During the last decades the number of large for gestational age infants delivered by nondiabetic mothers has increased. Our aim was to investigate to what extent fetal growth in nondiabetic pregnant women can be explained by rates of maternal energy substrate production and resting energy expenditure. Methods: Twenty nonsmoking pregnant women without impaired glucose tolerance and with a wide range of fetal weights (0.2–2.7 SDS) were investigated at 36 weeks of gestation. Maternal lipolysis, glucose production, resting energy expenditure, body composition and insulin resistance were assessed.Results: Median (range) glucose production rate was 805 (653–1,337) µmol/min and that of glycerol, reflecting lipolysis, was 214 (110–576) µmol/min. Multiple linear regression analysis showed that maternal fat mass explained 36% of the variation in insulin resistance, accounting for 62% of the variation in glucose production. Further, glucose production explained 31% of the variation in fetal weight. Resting energy expenditure explained 51% of the variation in estimated fetal weight. Conclusion: Fetal weight is dependent on maternal glucose production, which is in turn determined by the degree of insulin resistance, induced in part by the maternal fat mass. The variation in maternal resting energy expenditure is closely related to fetal weight.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>20431277</pmid><doi>10.1159/000295710</doi><tpages>8</tpages></addata></record> |
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| subjects | Adiposity Adult Basal Metabolism Body Composition Body Mass Index Female Fetal Macrosomia - epidemiology Fetal Weight Gluconeogenesis Humans Infant, Newborn Insulin Resistance Large for gestational age infants Lipolysis MEDICIN MEDICINE Original Paper Overweight - physiopathology Pregnancy Pregnancy Trimester, Third Ultrasonography, Prenatal |
| title | Insulin Resistance, a Link between Maternal Overweight and Fetal Macrosomia in Nondiabetic Pregnancies |
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