Efficient Synthesis of Pyrazoles: Oxidative C----C/N----N Bond-Formation Cascade
Golden section: A novel synthetic strategy for the synthesis of tetrasubstituted pyrazoles is provided. In an efficient CC/NN bond‐formation cascade, enamines and nitriles are oxidatively coupled to deliver pyrazoles in good yields (see scheme). The ready availability of the starting materials, th...
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| Veröffentlicht in: | Angewandte Chemie (International ed.) 2010-10, Vol.49 (42), p.7790-7794 |
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| container_issue | 42 |
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| container_title | Angewandte Chemie (International ed.) |
| container_volume | 49 |
| creator | Neumann, Julia J Suri, Mamta Glorius, Frank |
| description | Golden section: A novel synthetic strategy for the synthesis of tetrasubstituted pyrazoles is provided. In an efficient CC/NN bond‐formation cascade, enamines and nitriles are oxidatively coupled to deliver pyrazoles in good yields (see scheme). The ready availability of the starting materials, the high level of practicability of the reaction and work up, and the avoidance of hydrazine starting materials make the method attractive. |
| doi_str_mv | 10.1002/anie.201002389 |
| format | Article |
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| ispartof | Angewandte Chemie (International ed.), 2010-10, Vol.49 (42), p.7790-7794 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Carbon - chemistry Catalysis copper Copper - chemistry Cyclization enamines heterocycles Indoles - chemistry Molecular Structure Nitriles - chemistry Nitrogen - chemistry NN coupling oxidation Oxidation-Reduction Pyrazoles - chemical synthesis Pyrazoles - chemistry |
| title | Efficient Synthesis of Pyrazoles: Oxidative C----C/N----N Bond-Formation Cascade |
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