Effect of Doxycycline on Postoperative Scarring After Trabeculectomy in an Experimental Rabbit Model
To investigate effectiveness of doxycycline after trabeculectomy in rabbits by evaluating bleb appearance, intraocular pressure, and levels of matrix metalloproteinase-1, -2, -3, and -9 and tissue inhibitors of metalloproteinase (TIMP)-1 and -2 in the subconjunctival (sc) area. Twenty-nine New Zeala...
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| Veröffentlicht in: | Journal of ocular pharmacology and therapeutics 2010-10, Vol.26 (5), p.399-406 |
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| creator | SEN, Emine BALIKOGLU-YILMAZ, Melike ÖZTÜRK, Faruk BOZDAG-PEHLIVAN, Sibel SUNGU, Nuran AKSAKAL, Fatma Nur ALTINOK, Ayse TUNA, Tulay UNLU, Nursen USTUN, Huseyin KOKLU, Gultekin |
| description | To investigate effectiveness of doxycycline after trabeculectomy in rabbits by evaluating bleb appearance, intraocular pressure, and levels of matrix metalloproteinase-1, -2, -3, and -9 and tissue inhibitors of metalloproteinase (TIMP)-1 and -2 in the subconjunctival (sc) area.
Twenty-nine New Zealand White rabbits were assigned into 1 of 6 groups as follows: topical doxycycline (0.1%), postoperative sc injection of doxycycline (100 mg/2 mL), and intraoperative mitomycin-C (MMC) (0.2 mg/mL) and their respective control groups.
There was significant difference between intraocular pressure in the case groups, but there was no significant difference in topical doxycycline and MMC groups during the follow up. In the topical doxycycline group, levels of TIMP-1 and perifericTIMP-1 were higher and levels of perifericMMP-2 and inflammation were lower than their controls. In the sc doxycycline group, peripheral inflammation was higher than in the corresponding control. Only peripheral inflammation was significantly different between case groups, with the highest level in sc and the lowest level in MMC groups. Further, topical doxycycline group showed no significant difference in bleb appearance or peripheral inflammation compared with MMC group. Conjunctival burn and corneal vascularization were detected only in the sc doxycycline group.
Topical doxycycline is more effective than sc doxycycline but is similar to MMC, and it can be an alternative to MMC in trabeculectomy in rabbits. |
| doi_str_mv | 10.1089/jop.2010.0064 |
| format | Article |
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Twenty-nine New Zealand White rabbits were assigned into 1 of 6 groups as follows: topical doxycycline (0.1%), postoperative sc injection of doxycycline (100 mg/2 mL), and intraoperative mitomycin-C (MMC) (0.2 mg/mL) and their respective control groups.
There was significant difference between intraocular pressure in the case groups, but there was no significant difference in topical doxycycline and MMC groups during the follow up. In the topical doxycycline group, levels of TIMP-1 and perifericTIMP-1 were higher and levels of perifericMMP-2 and inflammation were lower than their controls. In the sc doxycycline group, peripheral inflammation was higher than in the corresponding control. Only peripheral inflammation was significantly different between case groups, with the highest level in sc and the lowest level in MMC groups. Further, topical doxycycline group showed no significant difference in bleb appearance or peripheral inflammation compared with MMC group. Conjunctival burn and corneal vascularization were detected only in the sc doxycycline group.
Topical doxycycline is more effective than sc doxycycline but is similar to MMC, and it can be an alternative to MMC in trabeculectomy in rabbits.</description><identifier>ISSN: 1080-7683</identifier><identifier>EISSN: 1557-7732</identifier><identifier>DOI: 10.1089/jop.2010.0064</identifier><identifier>PMID: 20874665</identifier><language>eng</language><publisher>Larchmont, NY: Liebert</publisher><subject>Animals ; Anti-Bacterial Agents - pharmacology ; Antibiotics, Antineoplastic - pharmacology ; Biological and medical sciences ; Blister - pathology ; Blister - surgery ; Cicatrix - complications ; Cicatrix - pathology ; Conjunctiva - drug effects ; Conjunctiva - pathology ; Conjunctiva - surgery ; Doxycycline - pharmacology ; Female ; Glaucoma - drug therapy ; Glaucoma - pathology ; Glaucoma - surgery ; Inflammation - metabolism ; Intraocular Pressure - drug effects ; Intraoperative Care ; Medical sciences ; Metalloproteases - pharmacology ; Mitomycin - pharmacology ; Models, Animal ; Pharmacology. Drug treatments ; Postoperative Period ; Rabbits ; Tissue Inhibitor of Metalloproteinases - pharmacology ; Trabeculectomy ; Wound Healing - drug effects</subject><ispartof>Journal of ocular pharmacology and therapeutics, 2010-10, Vol.26 (5), p.399-406</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c322t-d1813f6a6e2753829963762f346fa9f5fc13df3aa5c02dd8413ed9101efb7a153</citedby><cites>FETCH-LOGICAL-c322t-d1813f6a6e2753829963762f346fa9f5fc13df3aa5c02dd8413ed9101efb7a153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23356115$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20874665$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SEN, Emine</creatorcontrib><creatorcontrib>BALIKOGLU-YILMAZ, Melike</creatorcontrib><creatorcontrib>ÖZTÜRK, Faruk</creatorcontrib><creatorcontrib>BOZDAG-PEHLIVAN, Sibel</creatorcontrib><creatorcontrib>SUNGU, Nuran</creatorcontrib><creatorcontrib>AKSAKAL, Fatma Nur</creatorcontrib><creatorcontrib>ALTINOK, Ayse</creatorcontrib><creatorcontrib>TUNA, Tulay</creatorcontrib><creatorcontrib>UNLU, Nursen</creatorcontrib><creatorcontrib>USTUN, Huseyin</creatorcontrib><creatorcontrib>KOKLU, Gultekin</creatorcontrib><title>Effect of Doxycycline on Postoperative Scarring After Trabeculectomy in an Experimental Rabbit Model</title><title>Journal of ocular pharmacology and therapeutics</title><addtitle>J Ocul Pharmacol Ther</addtitle><description>To investigate effectiveness of doxycycline after trabeculectomy in rabbits by evaluating bleb appearance, intraocular pressure, and levels of matrix metalloproteinase-1, -2, -3, and -9 and tissue inhibitors of metalloproteinase (TIMP)-1 and -2 in the subconjunctival (sc) area.
Twenty-nine New Zealand White rabbits were assigned into 1 of 6 groups as follows: topical doxycycline (0.1%), postoperative sc injection of doxycycline (100 mg/2 mL), and intraoperative mitomycin-C (MMC) (0.2 mg/mL) and their respective control groups.
There was significant difference between intraocular pressure in the case groups, but there was no significant difference in topical doxycycline and MMC groups during the follow up. In the topical doxycycline group, levels of TIMP-1 and perifericTIMP-1 were higher and levels of perifericMMP-2 and inflammation were lower than their controls. In the sc doxycycline group, peripheral inflammation was higher than in the corresponding control. Only peripheral inflammation was significantly different between case groups, with the highest level in sc and the lowest level in MMC groups. Further, topical doxycycline group showed no significant difference in bleb appearance or peripheral inflammation compared with MMC group. Conjunctival burn and corneal vascularization were detected only in the sc doxycycline group.
Topical doxycycline is more effective than sc doxycycline but is similar to MMC, and it can be an alternative to MMC in trabeculectomy in rabbits.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotics, Antineoplastic - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Blister - pathology</subject><subject>Blister - surgery</subject><subject>Cicatrix - complications</subject><subject>Cicatrix - pathology</subject><subject>Conjunctiva - drug effects</subject><subject>Conjunctiva - pathology</subject><subject>Conjunctiva - surgery</subject><subject>Doxycycline - pharmacology</subject><subject>Female</subject><subject>Glaucoma - drug therapy</subject><subject>Glaucoma - pathology</subject><subject>Glaucoma - surgery</subject><subject>Inflammation - metabolism</subject><subject>Intraocular Pressure - drug effects</subject><subject>Intraoperative Care</subject><subject>Medical sciences</subject><subject>Metalloproteases - pharmacology</subject><subject>Mitomycin - pharmacology</subject><subject>Models, Animal</subject><subject>Pharmacology. Drug treatments</subject><subject>Postoperative Period</subject><subject>Rabbits</subject><subject>Tissue Inhibitor of Metalloproteinases - pharmacology</subject><subject>Trabeculectomy</subject><subject>Wound Healing - drug effects</subject><issn>1080-7683</issn><issn>1557-7732</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LAzEQhoMoWqtHr5KLeNqajybZPRatH6AoWs_LbHYiK9tNTbbS_ntTWvU0M_DMy8tDyBlnI87y4urTL0aCpYsxPd4jA66UyYyRYj_tLGeZ0bk8IscxfjLGJdP8kBwJlpux1mpA6qlzaHvqHb3xq7Vd27bpkPqOvvjY-wUG6JtvpG8WQmi6DzpxPQY6C1ChXbbp1c_XtOkodHS6Sngzx66Hlr5CVTU9ffI1tifkwEEb8XQ3h-T9djq7vs8en-8eriePmZVC9FnNcy6dBo3CKJmLotDSaOHkWDsonHKWy9pJAGWZqOt8zCXWBWccXWWAKzkkl9vcRfBfS4x9OW-ixbaFDv0ylkYZU0hT8ERmW9IGH2NAVy5ScwjrkrNy47VMXsuN13LjNfHnu-RlNcf6j_4VmYCLHQDRQusCdLaJ_5yUSvNU8Qfm1YEE</recordid><startdate>20101001</startdate><enddate>20101001</enddate><creator>SEN, Emine</creator><creator>BALIKOGLU-YILMAZ, Melike</creator><creator>ÖZTÜRK, Faruk</creator><creator>BOZDAG-PEHLIVAN, Sibel</creator><creator>SUNGU, Nuran</creator><creator>AKSAKAL, Fatma Nur</creator><creator>ALTINOK, Ayse</creator><creator>TUNA, Tulay</creator><creator>UNLU, Nursen</creator><creator>USTUN, Huseyin</creator><creator>KOKLU, Gultekin</creator><general>Liebert</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20101001</creationdate><title>Effect of Doxycycline on Postoperative Scarring After Trabeculectomy in an Experimental Rabbit Model</title><author>SEN, Emine ; BALIKOGLU-YILMAZ, Melike ; ÖZTÜRK, Faruk ; BOZDAG-PEHLIVAN, Sibel ; SUNGU, Nuran ; AKSAKAL, Fatma Nur ; ALTINOK, Ayse ; TUNA, Tulay ; UNLU, Nursen ; USTUN, Huseyin ; KOKLU, Gultekin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c322t-d1813f6a6e2753829963762f346fa9f5fc13df3aa5c02dd8413ed9101efb7a153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibiotics, Antineoplastic - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Blister - pathology</topic><topic>Blister - surgery</topic><topic>Cicatrix - complications</topic><topic>Cicatrix - pathology</topic><topic>Conjunctiva - drug effects</topic><topic>Conjunctiva - pathology</topic><topic>Conjunctiva - surgery</topic><topic>Doxycycline - pharmacology</topic><topic>Female</topic><topic>Glaucoma - drug therapy</topic><topic>Glaucoma - pathology</topic><topic>Glaucoma - surgery</topic><topic>Inflammation - metabolism</topic><topic>Intraocular Pressure - drug effects</topic><topic>Intraoperative Care</topic><topic>Medical sciences</topic><topic>Metalloproteases - pharmacology</topic><topic>Mitomycin - pharmacology</topic><topic>Models, Animal</topic><topic>Pharmacology. Drug treatments</topic><topic>Postoperative Period</topic><topic>Rabbits</topic><topic>Tissue Inhibitor of Metalloproteinases - pharmacology</topic><topic>Trabeculectomy</topic><topic>Wound Healing - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SEN, Emine</creatorcontrib><creatorcontrib>BALIKOGLU-YILMAZ, Melike</creatorcontrib><creatorcontrib>ÖZTÜRK, Faruk</creatorcontrib><creatorcontrib>BOZDAG-PEHLIVAN, Sibel</creatorcontrib><creatorcontrib>SUNGU, Nuran</creatorcontrib><creatorcontrib>AKSAKAL, Fatma Nur</creatorcontrib><creatorcontrib>ALTINOK, Ayse</creatorcontrib><creatorcontrib>TUNA, Tulay</creatorcontrib><creatorcontrib>UNLU, Nursen</creatorcontrib><creatorcontrib>USTUN, Huseyin</creatorcontrib><creatorcontrib>KOKLU, Gultekin</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ocular pharmacology and therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SEN, Emine</au><au>BALIKOGLU-YILMAZ, Melike</au><au>ÖZTÜRK, Faruk</au><au>BOZDAG-PEHLIVAN, Sibel</au><au>SUNGU, Nuran</au><au>AKSAKAL, Fatma Nur</au><au>ALTINOK, Ayse</au><au>TUNA, Tulay</au><au>UNLU, Nursen</au><au>USTUN, Huseyin</au><au>KOKLU, Gultekin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Doxycycline on Postoperative Scarring After Trabeculectomy in an Experimental Rabbit Model</atitle><jtitle>Journal of ocular pharmacology and therapeutics</jtitle><addtitle>J Ocul Pharmacol Ther</addtitle><date>2010-10-01</date><risdate>2010</risdate><volume>26</volume><issue>5</issue><spage>399</spage><epage>406</epage><pages>399-406</pages><issn>1080-7683</issn><eissn>1557-7732</eissn><abstract>To investigate effectiveness of doxycycline after trabeculectomy in rabbits by evaluating bleb appearance, intraocular pressure, and levels of matrix metalloproteinase-1, -2, -3, and -9 and tissue inhibitors of metalloproteinase (TIMP)-1 and -2 in the subconjunctival (sc) area.
Twenty-nine New Zealand White rabbits were assigned into 1 of 6 groups as follows: topical doxycycline (0.1%), postoperative sc injection of doxycycline (100 mg/2 mL), and intraoperative mitomycin-C (MMC) (0.2 mg/mL) and their respective control groups.
There was significant difference between intraocular pressure in the case groups, but there was no significant difference in topical doxycycline and MMC groups during the follow up. In the topical doxycycline group, levels of TIMP-1 and perifericTIMP-1 were higher and levels of perifericMMP-2 and inflammation were lower than their controls. In the sc doxycycline group, peripheral inflammation was higher than in the corresponding control. Only peripheral inflammation was significantly different between case groups, with the highest level in sc and the lowest level in MMC groups. Further, topical doxycycline group showed no significant difference in bleb appearance or peripheral inflammation compared with MMC group. Conjunctival burn and corneal vascularization were detected only in the sc doxycycline group.
Topical doxycycline is more effective than sc doxycycline but is similar to MMC, and it can be an alternative to MMC in trabeculectomy in rabbits.</abstract><cop>Larchmont, NY</cop><pub>Liebert</pub><pmid>20874665</pmid><doi>10.1089/jop.2010.0064</doi><tpages>8</tpages></addata></record> |
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| issn | 1080-7683 1557-7732 |
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| subjects | Animals Anti-Bacterial Agents - pharmacology Antibiotics, Antineoplastic - pharmacology Biological and medical sciences Blister - pathology Blister - surgery Cicatrix - complications Cicatrix - pathology Conjunctiva - drug effects Conjunctiva - pathology Conjunctiva - surgery Doxycycline - pharmacology Female Glaucoma - drug therapy Glaucoma - pathology Glaucoma - surgery Inflammation - metabolism Intraocular Pressure - drug effects Intraoperative Care Medical sciences Metalloproteases - pharmacology Mitomycin - pharmacology Models, Animal Pharmacology. Drug treatments Postoperative Period Rabbits Tissue Inhibitor of Metalloproteinases - pharmacology Trabeculectomy Wound Healing - drug effects |
| title | Effect of Doxycycline on Postoperative Scarring After Trabeculectomy in an Experimental Rabbit Model |
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