Stereocontrolled Creation of All-Carbon Quaternary Stereocenters by Organocatalytic Conjugate Addition of Oxindoles to Vinyl Sulfone

Multifunctional catalysts in operation: A novel class of trifunctional thiourea catalysts containing natural amino acid residues have been prepared (see scheme), and found to be very effective towards the asymmetric addition of 3‐alkyl‐oxindoles to 1,1‐bis(benzenesulfonyl)ethylene. This synthetic pr...

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Veröffentlicht in:	Angewandte Chemie (International ed.) 2010-10, Vol.49 (42), p.7753-7756
Hauptverfasser:	Zhu, Qiang, Lu, Yixin
Format:	Artikel
Sprache:	eng
Schlagworte:	amino acids Amino Acids - chemistry asymmetric synthesis Carbon - chemistry Catalysis conjugate addition Indoles - chemical synthesis Indoles - chemistry Molecular Structure multifunctional catalysts oxindoles Stereoisomerism Sulfones - chemistry Thiourea - chemistry
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