A functional cerebral response to frightening visual stimulation
The defense reaction, a fundamental reflex in the human behavioral response to threat, is characterized by anxiety and increased activity of the sympathetic nervous system. To study changes in regional cerebral blood flow (rCBF) related to the defense reaction, volunteers with snake phobia were inve...
Gespeichert in:
| Veröffentlicht in: | Psychiatry research 1993-04, Vol.50 (1), p.15-24 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 24 |
|---|---|
| container_issue | 1 |
| container_start_page | 15 |
| container_title | Psychiatry research |
| container_volume | 50 |
| creator | Wik, Gustav Fredrikson, Mats Ericson, Kaj Eriksson, Lars Stone-Elander, Sharon Greitz, Torgny |
| description | The defense reaction, a fundamental reflex in the human behavioral response to threat, is characterized by anxiety and increased activity of the sympathetic nervous system. To study changes in regional cerebral blood flow (rCBF) related to the defense reaction, volunteers with snake phobia were investigated with positron emission tomography. The relative rCBF during phobogenic visual stimulation was increased in the secondary visual cortex but reduced in the hippocampus, orbitofrontal, prefrontal, temporopolar, and posterior cingulate cortex compared with that observed during neutral visual stimulation. The relative rCBF under aversive stimulation was intermediate between phobic and neutral stimulation. The rCBF patterns observed are suggested to represent a functional cerebral correlate to the visually elicited defense reaction and its associated emotions. |
| doi_str_mv | 10.1016/0925-4927(93)90020-I |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_75777112</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>092549279390020I</els_id><sourcerecordid>75777112</sourcerecordid><originalsourceid>FETCH-LOGICAL-c386t-f9a7486bbbc7ad96ab6902c66b10aaff1c21a3aea21c788c7b4f775ba22008f23</originalsourceid><addsrcrecordid>eNp9kF1LwzAUhoMoc07_gUIvRPSimqRt0t6IY_gxGHij1-EkO9FI186kHfjvTd3YpVcJvM97cvIQcs7oLaNM3NGKF2lecXldZTcVpZym8wMyZqXkqSyoOCTjPXJMTkL4ikxWimxERmXBGOd0TB6mie0b07m2gTox6FH7ePEY1m0TMOnaxHr38dlh45qPZONCH-PQuVVfw9A6JUcW6oBnu3NC3p8e32Yv6eL1eT6bLlITn-xSW4HMS6G1NhKWlQAtKsqNEJpRAGuZ4QwyQODMyLI0UudWykJD3JKWlmcTcrWdu_btd4-hUysXDNY1NNj2QclCShk_FcF8CxrfhuDRqrV3K_A_ilE1iFODFTVYUVWm_sSpeaxd7Ob3eoXLfWlnKuaXuxyCgdp6aIwLeyyXuch4HrH7LYbRxcahV8E4bAwunUfTqWXr_t_jF6GCijo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>75777112</pqid></control><display><type>article</type><title>A functional cerebral response to frightening visual stimulation</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Wik, Gustav ; Fredrikson, Mats ; Ericson, Kaj ; Eriksson, Lars ; Stone-Elander, Sharon ; Greitz, Torgny</creator><creatorcontrib>Wik, Gustav ; Fredrikson, Mats ; Ericson, Kaj ; Eriksson, Lars ; Stone-Elander, Sharon ; Greitz, Torgny</creatorcontrib><description>The defense reaction, a fundamental reflex in the human behavioral response to threat, is characterized by anxiety and increased activity of the sympathetic nervous system. To study changes in regional cerebral blood flow (rCBF) related to the defense reaction, volunteers with snake phobia were investigated with positron emission tomography. The relative rCBF during phobogenic visual stimulation was increased in the secondary visual cortex but reduced in the hippocampus, orbitofrontal, prefrontal, temporopolar, and posterior cingulate cortex compared with that observed during neutral visual stimulation. The relative rCBF under aversive stimulation was intermediate between phobic and neutral stimulation. The rCBF patterns observed are suggested to represent a functional cerebral correlate to the visually elicited defense reaction and its associated emotions.</description><identifier>ISSN: 0925-4927</identifier><identifier>ISSN: 0165-1781</identifier><identifier>EISSN: 1872-7506</identifier><identifier>EISSN: 1872-7123</identifier><identifier>DOI: 10.1016/0925-4927(93)90020-I</identifier><identifier>PMID: 8511220</identifier><identifier>CODEN: PSRSDR</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult ; Adult and adolescent clinical studies ; Analysis of Variance ; anxiety ; Anxiety disorders. Neuroses ; Biological and medical sciences ; Cerebrovascular Circulation - physiology ; defense reaction ; Fear ; Female ; Heart Rate - physiology ; Humans ; Medical sciences ; Phobic Disorders - diagnostic imaging ; Phobic Disorders - physiopathology ; Photic Stimulation ; Positron emission tomography ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; simple phobia ; Tomography, Emission-Computed ; Visual Cortex - blood supply ; Visual Cortex - diagnostic imaging</subject><ispartof>Psychiatry research, 1993-04, Vol.50 (1), p.15-24</ispartof><rights>1993</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-f9a7486bbbc7ad96ab6902c66b10aaff1c21a3aea21c788c7b4f775ba22008f23</citedby><cites>FETCH-LOGICAL-c386t-f9a7486bbbc7ad96ab6902c66b10aaff1c21a3aea21c788c7b4f775ba22008f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/092549279390020I$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4746324$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8511220$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wik, Gustav</creatorcontrib><creatorcontrib>Fredrikson, Mats</creatorcontrib><creatorcontrib>Ericson, Kaj</creatorcontrib><creatorcontrib>Eriksson, Lars</creatorcontrib><creatorcontrib>Stone-Elander, Sharon</creatorcontrib><creatorcontrib>Greitz, Torgny</creatorcontrib><title>A functional cerebral response to frightening visual stimulation</title><title>Psychiatry research</title><addtitle>Psychiatry Res</addtitle><description>The defense reaction, a fundamental reflex in the human behavioral response to threat, is characterized by anxiety and increased activity of the sympathetic nervous system. To study changes in regional cerebral blood flow (rCBF) related to the defense reaction, volunteers with snake phobia were investigated with positron emission tomography. The relative rCBF during phobogenic visual stimulation was increased in the secondary visual cortex but reduced in the hippocampus, orbitofrontal, prefrontal, temporopolar, and posterior cingulate cortex compared with that observed during neutral visual stimulation. The relative rCBF under aversive stimulation was intermediate between phobic and neutral stimulation. The rCBF patterns observed are suggested to represent a functional cerebral correlate to the visually elicited defense reaction and its associated emotions.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Analysis of Variance</subject><subject>anxiety</subject><subject>Anxiety disorders. Neuroses</subject><subject>Biological and medical sciences</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>defense reaction</subject><subject>Fear</subject><subject>Female</subject><subject>Heart Rate - physiology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Phobic Disorders - diagnostic imaging</subject><subject>Phobic Disorders - physiopathology</subject><subject>Photic Stimulation</subject><subject>Positron emission tomography</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>simple phobia</subject><subject>Tomography, Emission-Computed</subject><subject>Visual Cortex - blood supply</subject><subject>Visual Cortex - diagnostic imaging</subject><issn>0925-4927</issn><issn>0165-1781</issn><issn>1872-7506</issn><issn>1872-7123</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1LwzAUhoMoc07_gUIvRPSimqRt0t6IY_gxGHij1-EkO9FI186kHfjvTd3YpVcJvM97cvIQcs7oLaNM3NGKF2lecXldZTcVpZym8wMyZqXkqSyoOCTjPXJMTkL4ikxWimxERmXBGOd0TB6mie0b07m2gTox6FH7ePEY1m0TMOnaxHr38dlh45qPZONCH-PQuVVfw9A6JUcW6oBnu3NC3p8e32Yv6eL1eT6bLlITn-xSW4HMS6G1NhKWlQAtKsqNEJpRAGuZ4QwyQODMyLI0UudWykJD3JKWlmcTcrWdu_btd4-hUysXDNY1NNj2QclCShk_FcF8CxrfhuDRqrV3K_A_ilE1iFODFTVYUVWm_sSpeaxd7Ob3eoXLfWlnKuaXuxyCgdp6aIwLeyyXuch4HrH7LYbRxcahV8E4bAwunUfTqWXr_t_jF6GCijo</recordid><startdate>19930401</startdate><enddate>19930401</enddate><creator>Wik, Gustav</creator><creator>Fredrikson, Mats</creator><creator>Ericson, Kaj</creator><creator>Eriksson, Lars</creator><creator>Stone-Elander, Sharon</creator><creator>Greitz, Torgny</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930401</creationdate><title>A functional cerebral response to frightening visual stimulation</title><author>Wik, Gustav ; Fredrikson, Mats ; Ericson, Kaj ; Eriksson, Lars ; Stone-Elander, Sharon ; Greitz, Torgny</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-f9a7486bbbc7ad96ab6902c66b10aaff1c21a3aea21c788c7b4f775ba22008f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Analysis of Variance</topic><topic>anxiety</topic><topic>Anxiety disorders. Neuroses</topic><topic>Biological and medical sciences</topic><topic>Cerebrovascular Circulation - physiology</topic><topic>defense reaction</topic><topic>Fear</topic><topic>Female</topic><topic>Heart Rate - physiology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Phobic Disorders - diagnostic imaging</topic><topic>Phobic Disorders - physiopathology</topic><topic>Photic Stimulation</topic><topic>Positron emission tomography</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>simple phobia</topic><topic>Tomography, Emission-Computed</topic><topic>Visual Cortex - blood supply</topic><topic>Visual Cortex - diagnostic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wik, Gustav</creatorcontrib><creatorcontrib>Fredrikson, Mats</creatorcontrib><creatorcontrib>Ericson, Kaj</creatorcontrib><creatorcontrib>Eriksson, Lars</creatorcontrib><creatorcontrib>Stone-Elander, Sharon</creatorcontrib><creatorcontrib>Greitz, Torgny</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wik, Gustav</au><au>Fredrikson, Mats</au><au>Ericson, Kaj</au><au>Eriksson, Lars</au><au>Stone-Elander, Sharon</au><au>Greitz, Torgny</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A functional cerebral response to frightening visual stimulation</atitle><jtitle>Psychiatry research</jtitle><addtitle>Psychiatry Res</addtitle><date>1993-04-01</date><risdate>1993</risdate><volume>50</volume><issue>1</issue><spage>15</spage><epage>24</epage><pages>15-24</pages><issn>0925-4927</issn><issn>0165-1781</issn><eissn>1872-7506</eissn><eissn>1872-7123</eissn><coden>PSRSDR</coden><abstract>The defense reaction, a fundamental reflex in the human behavioral response to threat, is characterized by anxiety and increased activity of the sympathetic nervous system. To study changes in regional cerebral blood flow (rCBF) related to the defense reaction, volunteers with snake phobia were investigated with positron emission tomography. The relative rCBF during phobogenic visual stimulation was increased in the secondary visual cortex but reduced in the hippocampus, orbitofrontal, prefrontal, temporopolar, and posterior cingulate cortex compared with that observed during neutral visual stimulation. The relative rCBF under aversive stimulation was intermediate between phobic and neutral stimulation. The rCBF patterns observed are suggested to represent a functional cerebral correlate to the visually elicited defense reaction and its associated emotions.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>8511220</pmid><doi>10.1016/0925-4927(93)90020-I</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0925-4927 |
| ispartof | Psychiatry research, 1993-04, Vol.50 (1), p.15-24 |
| issn | 0925-4927 0165-1781 1872-7506 1872-7123 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75777112 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Adult and adolescent clinical studies Analysis of Variance anxiety Anxiety disorders. Neuroses Biological and medical sciences Cerebrovascular Circulation - physiology defense reaction Fear Female Heart Rate - physiology Humans Medical sciences Phobic Disorders - diagnostic imaging Phobic Disorders - physiopathology Photic Stimulation Positron emission tomography Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry simple phobia Tomography, Emission-Computed Visual Cortex - blood supply Visual Cortex - diagnostic imaging |
| title | A functional cerebral response to frightening visual stimulation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T13%3A27%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20functional%20cerebral%20response%20to%20frightening%20visual%20stimulation&rft.jtitle=Psychiatry%20research&rft.au=Wik,%20Gustav&rft.date=1993-04-01&rft.volume=50&rft.issue=1&rft.spage=15&rft.epage=24&rft.pages=15-24&rft.issn=0925-4927&rft.eissn=1872-7506&rft.coden=PSRSDR&rft_id=info:doi/10.1016/0925-4927(93)90020-I&rft_dat=%3Cproquest_cross%3E75777112%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=75777112&rft_id=info:pmid/8511220&rft_els_id=092549279390020I&rfr_iscdi=true |