Effects of Intrauterine Malnutrition on Brain Free Amino Acids of Young Rats, After Nutritional Recovery During Lactation Period

The effect of protein‐calorie malnutrition during gestation on the brain amino acids of rat pups was studied following nutritional recovery during lactation. The brain amino acids of rat pups born to dam rats malnourished during gestation were studied after these rat pups received proper nutrition d...

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Veröffentlicht in:Journal of pediatric gastroenterology and nutrition 1984-11, Vol.3 (5), p.795-800
Hauptverfasser: Petean Trindade, Cleíde Enoir, Nóbrega, Fernando José, Souza Queiróz Tonete, Suzana, Aiello Sartor, Maria Eneida, Curi, Paulo Roberto
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container_end_page 800
container_issue 5
container_start_page 795
container_title Journal of pediatric gastroenterology and nutrition
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creator Petean Trindade, Cleíde Enoir
Nóbrega, Fernando José
Souza Queiróz Tonete, Suzana
Aiello Sartor, Maria Eneida
Curi, Paulo Roberto
description The effect of protein‐calorie malnutrition during gestation on the brain amino acids of rat pups was studied following nutritional recovery during lactation. The brain amino acids of rat pups born to dam rats malnourished during gestation were studied after these rat pups received proper nutrition during lactation. Pregnant rats were fed a 1% protein diet with total caloric intake restricted to half that of controls. After birth, the offspring of rats fed on deficient diets were nurtured up to the 28th day postpartum by foster mothers receiving adequate diets. At this time, the offspring were killed. The control group consisted of offspring from pregnant rats fed a diet with adequate protein (21%) and calories during the entire gestation and lactation period. Quantitation of brain amino acids in the pups at 28 days postpartum showed lower concentrations of essential and nonessential amino acids in the rats malnourished during gestation. Concentrations of histidine, glycine, and α‐aminobutyric acid were all reduced. These findings demonstrate that the brains of rat pups malnourished during gestation show persistent decreases in specific brain amino acids after adequate postpartum nutrition.
doi_str_mv 10.1002/j.1536-4801.1984.tb08770.x
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The brain amino acids of rat pups born to dam rats malnourished during gestation were studied after these rat pups received proper nutrition during lactation. Pregnant rats were fed a 1% protein diet with total caloric intake restricted to half that of controls. After birth, the offspring of rats fed on deficient diets were nurtured up to the 28th day postpartum by foster mothers receiving adequate diets. At this time, the offspring were killed. The control group consisted of offspring from pregnant rats fed a diet with adequate protein (21%) and calories during the entire gestation and lactation period. Quantitation of brain amino acids in the pups at 28 days postpartum showed lower concentrations of essential and nonessential amino acids in the rats malnourished during gestation. Concentrations of histidine, glycine, and α‐aminobutyric acid were all reduced. These findings demonstrate that the brains of rat pups malnourished during gestation show persistent decreases in specific brain amino acids after adequate postpartum nutrition.</description><identifier>ISSN: 0277-2116</identifier><identifier>EISSN: 1536-4801</identifier><identifier>DOI: 10.1002/j.1536-4801.1984.tb08770.x</identifier><identifier>PMID: 6502380</identifier><identifier>CODEN: JPGND6</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Amino Acids - metabolism ; Amino Acids, Essential - metabolism ; Animals ; Animals, Suckling - physiology ; Biological and medical sciences ; Brain - metabolism ; Brain amino acids ; Dietary Proteins - administration &amp; dosage ; Diseases of mother, fetus and pregnancy ; Energy Intake ; Female ; Gynecology. Andrology. Obstetrics ; Intrauterine malnutrition ; Lactation ; Medical sciences ; Nutrition Disorders - physiopathology ; Organ Size ; Placenta Diseases - metabolism ; Placenta Diseases - physiopathology ; Pregnancy ; Pregnancy. Fetus. 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The brain amino acids of rat pups born to dam rats malnourished during gestation were studied after these rat pups received proper nutrition during lactation. Pregnant rats were fed a 1% protein diet with total caloric intake restricted to half that of controls. After birth, the offspring of rats fed on deficient diets were nurtured up to the 28th day postpartum by foster mothers receiving adequate diets. At this time, the offspring were killed. The control group consisted of offspring from pregnant rats fed a diet with adequate protein (21%) and calories during the entire gestation and lactation period. Quantitation of brain amino acids in the pups at 28 days postpartum showed lower concentrations of essential and nonessential amino acids in the rats malnourished during gestation. Concentrations of histidine, glycine, and α‐aminobutyric acid were all reduced. These findings demonstrate that the brains of rat pups malnourished during gestation show persistent decreases in specific brain amino acids after adequate postpartum nutrition.</description><subject>Amino Acids - metabolism</subject><subject>Amino Acids, Essential - metabolism</subject><subject>Animals</subject><subject>Animals, Suckling - physiology</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Brain amino acids</subject><subject>Dietary Proteins - administration &amp; dosage</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Energy Intake</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Intrauterine malnutrition</subject><subject>Lactation</subject><subject>Medical sciences</subject><subject>Nutrition Disorders - physiopathology</subject><subject>Organ Size</subject><subject>Placenta Diseases - metabolism</subject><subject>Placenta Diseases - physiopathology</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. 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Andrology. Obstetrics</topic><topic>Intrauterine malnutrition</topic><topic>Lactation</topic><topic>Medical sciences</topic><topic>Nutrition Disorders - physiopathology</topic><topic>Organ Size</topic><topic>Placenta Diseases - metabolism</topic><topic>Placenta Diseases - physiopathology</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. 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The brain amino acids of rat pups born to dam rats malnourished during gestation were studied after these rat pups received proper nutrition during lactation. Pregnant rats were fed a 1% protein diet with total caloric intake restricted to half that of controls. After birth, the offspring of rats fed on deficient diets were nurtured up to the 28th day postpartum by foster mothers receiving adequate diets. At this time, the offspring were killed. The control group consisted of offspring from pregnant rats fed a diet with adequate protein (21%) and calories during the entire gestation and lactation period. Quantitation of brain amino acids in the pups at 28 days postpartum showed lower concentrations of essential and nonessential amino acids in the rats malnourished during gestation. Concentrations of histidine, glycine, and α‐aminobutyric acid were all reduced. 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identifier ISSN: 0277-2116
ispartof Journal of pediatric gastroenterology and nutrition, 1984-11, Vol.3 (5), p.795-800
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subjects Amino Acids - metabolism
Amino Acids, Essential - metabolism
Animals
Animals, Suckling - physiology
Biological and medical sciences
Brain - metabolism
Brain amino acids
Dietary Proteins - administration & dosage
Diseases of mother, fetus and pregnancy
Energy Intake
Female
Gynecology. Andrology. Obstetrics
Intrauterine malnutrition
Lactation
Medical sciences
Nutrition Disorders - physiopathology
Organ Size
Placenta Diseases - metabolism
Placenta Diseases - physiopathology
Pregnancy
Pregnancy. Fetus. Placenta
Protein‐calorie malnutrition
Rats
Rats, Inbred Strains
title Effects of Intrauterine Malnutrition on Brain Free Amino Acids of Young Rats, After Nutritional Recovery During Lactation Period
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