Effects of Intrauterine Malnutrition on Brain Free Amino Acids of Young Rats, After Nutritional Recovery During Lactation Period
The effect of protein‐calorie malnutrition during gestation on the brain amino acids of rat pups was studied following nutritional recovery during lactation. The brain amino acids of rat pups born to dam rats malnourished during gestation were studied after these rat pups received proper nutrition d...
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| Veröffentlicht in: | Journal of pediatric gastroenterology and nutrition 1984-11, Vol.3 (5), p.795-800 |
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| container_title | Journal of pediatric gastroenterology and nutrition |
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| creator | Petean Trindade, Cleíde Enoir Nóbrega, Fernando José Souza Queiróz Tonete, Suzana Aiello Sartor, Maria Eneida Curi, Paulo Roberto |
| description | The effect of protein‐calorie malnutrition during gestation on the brain amino acids of rat pups was studied following nutritional recovery during lactation. The brain amino acids of rat pups born to dam rats malnourished during gestation were studied after these rat pups received proper nutrition during lactation. Pregnant rats were fed a 1% protein diet with total caloric intake restricted to half that of controls. After birth, the offspring of rats fed on deficient diets were nurtured up to the 28th day postpartum by foster mothers receiving adequate diets. At this time, the offspring were killed. The control group consisted of offspring from pregnant rats fed a diet with adequate protein (21%) and calories during the entire gestation and lactation period. Quantitation of brain amino acids in the pups at 28 days postpartum showed lower concentrations of essential and nonessential amino acids in the rats malnourished during gestation. Concentrations of histidine, glycine, and α‐aminobutyric acid were all reduced. These findings demonstrate that the brains of rat pups malnourished during gestation show persistent decreases in specific brain amino acids after adequate postpartum nutrition. |
| doi_str_mv | 10.1002/j.1536-4801.1984.tb08770.x |
| format | Article |
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The brain amino acids of rat pups born to dam rats malnourished during gestation were studied after these rat pups received proper nutrition during lactation. Pregnant rats were fed a 1% protein diet with total caloric intake restricted to half that of controls. After birth, the offspring of rats fed on deficient diets were nurtured up to the 28th day postpartum by foster mothers receiving adequate diets. At this time, the offspring were killed. The control group consisted of offspring from pregnant rats fed a diet with adequate protein (21%) and calories during the entire gestation and lactation period. Quantitation of brain amino acids in the pups at 28 days postpartum showed lower concentrations of essential and nonessential amino acids in the rats malnourished during gestation. Concentrations of histidine, glycine, and α‐aminobutyric acid were all reduced. These findings demonstrate that the brains of rat pups malnourished during gestation show persistent decreases in specific brain amino acids after adequate postpartum nutrition.</description><identifier>ISSN: 0277-2116</identifier><identifier>EISSN: 1536-4801</identifier><identifier>DOI: 10.1002/j.1536-4801.1984.tb08770.x</identifier><identifier>PMID: 6502380</identifier><identifier>CODEN: JPGND6</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Amino Acids - metabolism ; Amino Acids, Essential - metabolism ; Animals ; Animals, Suckling - physiology ; Biological and medical sciences ; Brain - metabolism ; Brain amino acids ; Dietary Proteins - administration & dosage ; Diseases of mother, fetus and pregnancy ; Energy Intake ; Female ; Gynecology. Andrology. Obstetrics ; Intrauterine malnutrition ; Lactation ; Medical sciences ; Nutrition Disorders - physiopathology ; Organ Size ; Placenta Diseases - metabolism ; Placenta Diseases - physiopathology ; Pregnancy ; Pregnancy. Fetus. Placenta ; Protein‐calorie malnutrition ; Rats ; Rats, Inbred Strains</subject><ispartof>Journal of pediatric gastroenterology and nutrition, 1984-11, Vol.3 (5), p.795-800</ispartof><rights>1984 by European Society for European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition</rights><rights>Lippincott-Raven Publishers.</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9127201$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6502380$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Petean Trindade, Cleíde Enoir</creatorcontrib><creatorcontrib>Nóbrega, Fernando José</creatorcontrib><creatorcontrib>Souza Queiróz Tonete, Suzana</creatorcontrib><creatorcontrib>Aiello Sartor, Maria Eneida</creatorcontrib><creatorcontrib>Curi, Paulo Roberto</creatorcontrib><title>Effects of Intrauterine Malnutrition on Brain Free Amino Acids of Young Rats, After Nutritional Recovery During Lactation Period</title><title>Journal of pediatric gastroenterology and nutrition</title><addtitle>J Pediatr Gastroenterol Nutr</addtitle><description>The effect of protein‐calorie malnutrition during gestation on the brain amino acids of rat pups was studied following nutritional recovery during lactation. The brain amino acids of rat pups born to dam rats malnourished during gestation were studied after these rat pups received proper nutrition during lactation. Pregnant rats were fed a 1% protein diet with total caloric intake restricted to half that of controls. After birth, the offspring of rats fed on deficient diets were nurtured up to the 28th day postpartum by foster mothers receiving adequate diets. At this time, the offspring were killed. The control group consisted of offspring from pregnant rats fed a diet with adequate protein (21%) and calories during the entire gestation and lactation period. Quantitation of brain amino acids in the pups at 28 days postpartum showed lower concentrations of essential and nonessential amino acids in the rats malnourished during gestation. Concentrations of histidine, glycine, and α‐aminobutyric acid were all reduced. These findings demonstrate that the brains of rat pups malnourished during gestation show persistent decreases in specific brain amino acids after adequate postpartum nutrition.</description><subject>Amino Acids - metabolism</subject><subject>Amino Acids, Essential - metabolism</subject><subject>Animals</subject><subject>Animals, Suckling - physiology</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Brain amino acids</subject><subject>Dietary Proteins - administration & dosage</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Energy Intake</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Intrauterine malnutrition</subject><subject>Lactation</subject><subject>Medical sciences</subject><subject>Nutrition Disorders - physiopathology</subject><subject>Organ Size</subject><subject>Placenta Diseases - metabolism</subject><subject>Placenta Diseases - physiopathology</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Protein‐calorie malnutrition</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0277-2116</issn><issn>1536-4801</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkUFv0zAUxy0EGt3gIyBZCHEi4dmx44RbV1YYKmOa4MDJenXsLSVNhp1s642PjrOG3pFs-fD-v_fsnwl5zSBlAPz9JmUyyxNRAEtZWYi0X0OhFKQPT8jsUHpKZsCVSjhj-XNyHMIGAJSQcESOcgk8K2BG_pw5Z00faOfoedt7HHrr69bSr9i0Q-_rvu5aGtepx7qlS28tnW_rtqNzU1eP2M9uaK_pFfbhHZ27iNOLfyA29Mqa7s76Hf04xL7XdIWmx8eml3FQV70gzxw2wb6czhPyY3n2ffE5WX37dL6YrxKT8Uwl0pUOK7kWMi-dLTNAkZUS11jlnEmwxkheVILzCh04VnApoCrjM1FxxwRmJ-Ttvu-t734PNvR6WwdjmwZb2w1BK6lUzrIiBj_sg8Z3IXjr9K2vt-h3moEe9euNHh3r0bEe9etJv36I8KtpyrDe2uqATr5j_c1Ux2CwcR5bU4dDrGRccWAxJvax-66JQsOvZri3Xt9YbPobHb8RJFN5Mg5n8UqQxM1VxBYTVjd29x_31l8uL7LTJYOSi-wvYlmzbQ</recordid><startdate>198411</startdate><enddate>198411</enddate><creator>Petean Trindade, Cleíde Enoir</creator><creator>Nóbrega, Fernando José</creator><creator>Souza Queiróz Tonete, Suzana</creator><creator>Aiello Sartor, Maria Eneida</creator><creator>Curi, Paulo Roberto</creator><general>Lippincott-Raven Publishers</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198411</creationdate><title>Effects of Intrauterine Malnutrition on Brain Free Amino Acids of Young Rats, After Nutritional Recovery During Lactation Period</title><author>Petean Trindade, Cleíde Enoir ; Nóbrega, Fernando José ; Souza Queiróz Tonete, Suzana ; Aiello Sartor, Maria Eneida ; Curi, Paulo Roberto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3237-5f9fad5b4569fe930a4395abad62150ecc528d422daf0f182540d9650a72f14a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Amino Acids - metabolism</topic><topic>Amino Acids, Essential - metabolism</topic><topic>Animals</topic><topic>Animals, Suckling - physiology</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Brain amino acids</topic><topic>Dietary Proteins - administration & dosage</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Energy Intake</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Intrauterine malnutrition</topic><topic>Lactation</topic><topic>Medical sciences</topic><topic>Nutrition Disorders - physiopathology</topic><topic>Organ Size</topic><topic>Placenta Diseases - metabolism</topic><topic>Placenta Diseases - physiopathology</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Protein‐calorie malnutrition</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Petean Trindade, Cleíde Enoir</creatorcontrib><creatorcontrib>Nóbrega, Fernando José</creatorcontrib><creatorcontrib>Souza Queiróz Tonete, Suzana</creatorcontrib><creatorcontrib>Aiello Sartor, Maria Eneida</creatorcontrib><creatorcontrib>Curi, Paulo Roberto</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Petean Trindade, Cleíde Enoir</au><au>Nóbrega, Fernando José</au><au>Souza Queiróz Tonete, Suzana</au><au>Aiello Sartor, Maria Eneida</au><au>Curi, Paulo Roberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Intrauterine Malnutrition on Brain Free Amino Acids of Young Rats, After Nutritional Recovery During Lactation Period</atitle><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle><addtitle>J Pediatr Gastroenterol Nutr</addtitle><date>1984-11</date><risdate>1984</risdate><volume>3</volume><issue>5</issue><spage>795</spage><epage>800</epage><pages>795-800</pages><issn>0277-2116</issn><eissn>1536-4801</eissn><coden>JPGND6</coden><abstract>The effect of protein‐calorie malnutrition during gestation on the brain amino acids of rat pups was studied following nutritional recovery during lactation. The brain amino acids of rat pups born to dam rats malnourished during gestation were studied after these rat pups received proper nutrition during lactation. Pregnant rats were fed a 1% protein diet with total caloric intake restricted to half that of controls. After birth, the offspring of rats fed on deficient diets were nurtured up to the 28th day postpartum by foster mothers receiving adequate diets. At this time, the offspring were killed. The control group consisted of offspring from pregnant rats fed a diet with adequate protein (21%) and calories during the entire gestation and lactation period. Quantitation of brain amino acids in the pups at 28 days postpartum showed lower concentrations of essential and nonessential amino acids in the rats malnourished during gestation. Concentrations of histidine, glycine, and α‐aminobutyric acid were all reduced. These findings demonstrate that the brains of rat pups malnourished during gestation show persistent decreases in specific brain amino acids after adequate postpartum nutrition.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>6502380</pmid><doi>10.1002/j.1536-4801.1984.tb08770.x</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of pediatric gastroenterology and nutrition, 1984-11, Vol.3 (5), p.795-800 |
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| subjects | Amino Acids - metabolism Amino Acids, Essential - metabolism Animals Animals, Suckling - physiology Biological and medical sciences Brain - metabolism Brain amino acids Dietary Proteins - administration & dosage Diseases of mother, fetus and pregnancy Energy Intake Female Gynecology. Andrology. Obstetrics Intrauterine malnutrition Lactation Medical sciences Nutrition Disorders - physiopathology Organ Size Placenta Diseases - metabolism Placenta Diseases - physiopathology Pregnancy Pregnancy. Fetus. Placenta Protein‐calorie malnutrition Rats Rats, Inbred Strains |
| title | Effects of Intrauterine Malnutrition on Brain Free Amino Acids of Young Rats, After Nutritional Recovery During Lactation Period |
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