Defective phagocytosis in chronic trichophytosis

Chronic trichophytosis as a primary clinical entity (primary chronic trichophytosis, PCT) is increasingly encountered in the literature. Its prevalent cause in Croatia is the anthropophilic form of Trichophyton interdigitale. Chronicity of the disease may result from immunological defects of the pat...

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Veröffentlicht in:Journal of medical and veterinary mycology 1993, Vol.31 (2), p.115-120
Hauptverfasser: GREGUREK-NOVAK, T, RABATIC, S, SILOBRCIC, V
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RABATIC, S
SILOBRCIC, V
description Chronic trichophytosis as a primary clinical entity (primary chronic trichophytosis, PCT) is increasingly encountered in the literature. Its prevalent cause in Croatia is the anthropophilic form of Trichophyton interdigitale. Chronicity of the disease may result from immunological defects of the patients. Thus, in 62 patients with PCT: skin testing, enumeration of T- and B-lymphocytes in the peripheral blood, quantitation of immunoglobulin classes, and phagocytosis (random mobility, ingestion, digestion and extracellular killing) by peripheral blood leukocytes was tested. The findings were compared to those in healthy persons. Defective phagocytosis (random mobility, ingestion and digestion) was found in patients with PCT (P < 0.001). All the other results were within the control range. Therefore, PCT seems to be associated with defective phagocytosis of peripheral blood leukocytes in affected persons.
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source MEDLINE; Oxford University Press Journals Digital Archive Legacy; Taylor & Francis Journals Complete
subjects B-Lymphocytes - immunology
Biological and medical sciences
Chronic Disease
Female
Human mycoses
Humans
Infectious diseases
Leukocytes - immunology
Leukocytes - physiology
Male
Medical sciences
Mycoses
Mycoses of the skin
Phagocytosis
Skin - microbiology
Skin Tests
T-Lymphocytes - immunology
Tinea - blood
Tinea - immunology
Trichophyton - isolation & purification
title Defective phagocytosis in chronic trichophytosis
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