Studies on Novel Bone Resorption Inhibitors. I. Synthesis and Pharmacological Activities of Aminomethylenebisphosphonate Derivatives

A series of aminomethylenebisphosphonate derivatives was synthesized and evaluated for their antiresorptive activities using a parathyroid hormone (PTH)-induced hypercalemia model in rats (PIH model). Among these compounds, (cycloheptylamino)methylenebis(phosphonic acid) (3j) was finally selected fo...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1993/04/15, Vol.41(4), pp.688-693
Hauptverfasser:	TAKEUCHI, Makoto, SAKAMOTO, Shuichi, YOSHIDA, Makoto, ABE, Tetsushi, ISOMURA, Yasuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals bisphosphonate Bone Resorption - drug therapy bone resorption inhibitor Chemistry Diphosphonates - chemical synthesis Diphosphonates - therapeutic use etidronate Exact sciences and technology Hypercalcemia - drug therapy Male Organic chemistry Organometalloidal and organometallic compounds osteoporosis P derivatives pamidronate Preparations and properties Rats Rats, Wistar Structure-Activity Relationship YM175
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