Phakomatous choristoma (Zimmerman's tumor) : immunohistochemical confirmation of lens-specific proteins
Phakomatous choristoma is a rare, congenital, ocular adnexal tumor that is presumed to be of lenticular anlage based on light and electron microscopy. The authors performed immunohistochemistry using standard commercially available antibodies against vimentin, S-100 protein, and several cytokeratins...
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| Veröffentlicht in: | Ophthalmology (Rochester, MN) MN), 1993-06, Vol.100 (6), p.955-960 |
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| container_title | Ophthalmology (Rochester, MN) |
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| creator | ELLIS, F. J EAGLE, R. C SHIELDS, J. A SHIELDS, C. L FESSLER, J. N TAKEMOTO, L. J |
| description | Phakomatous choristoma is a rare, congenital, ocular adnexal tumor that is presumed to be of lenticular anlage based on light and electron microscopy.
The authors performed immunohistochemistry using standard commercially available antibodies against vimentin, S-100 protein, and several cytokeratins on a phakomatous choristoma that was excised from the right lower eyelid of a 10-week-old white boy. In addition, a battery of antibodies against lens-specific proteins, including alpha, beta, and gamma crystallins, was used.
The tumor cells showed intense immunoreactivity for all lens-specific proteins tested. The epithelial cells of the phakomatous choristoma stained positively for S-100 protein and vimentin, the intermediate filament normally found in lens epithelial cells. Keratin markers were negative.
The results of immunohistochemistry indicate that the cells of phakomatous choristoma synthesize several types of lens-specific proteins. Complementing previous light and electron microscopic studies, these data strongly support Zimmerman's conclusion that this pediatric adnexal tumor is a choristoma of lenticular anlage. |
| doi_str_mv | 10.1016/S0161-6420(93)31573-3 |
| format | Article |
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The authors performed immunohistochemistry using standard commercially available antibodies against vimentin, S-100 protein, and several cytokeratins on a phakomatous choristoma that was excised from the right lower eyelid of a 10-week-old white boy. In addition, a battery of antibodies against lens-specific proteins, including alpha, beta, and gamma crystallins, was used.
The tumor cells showed intense immunoreactivity for all lens-specific proteins tested. The epithelial cells of the phakomatous choristoma stained positively for S-100 protein and vimentin, the intermediate filament normally found in lens epithelial cells. Keratin markers were negative.
The results of immunohistochemistry indicate that the cells of phakomatous choristoma synthesize several types of lens-specific proteins. Complementing previous light and electron microscopic studies, these data strongly support Zimmerman's conclusion that this pediatric adnexal tumor is a choristoma of lenticular anlage.</description><identifier>ISSN: 0161-6420</identifier><identifier>EISSN: 1549-4713</identifier><identifier>DOI: 10.1016/S0161-6420(93)31573-3</identifier><identifier>PMID: 7685513</identifier><identifier>CODEN: OPHTDG</identifier><language>eng</language><publisher>New York, NY: Elsevier</publisher><subject>Antibodies, Monoclonal ; Biological and medical sciences ; Choristoma - diagnostic imaging ; Choristoma - metabolism ; Crystallins - metabolism ; Epithelium - pathology ; Eyelid Neoplasms - diagnostic imaging ; Eyelid Neoplasms - metabolism ; Humans ; Immunoenzyme Techniques ; Infant ; Keratins - metabolism ; Lens, Crystalline ; Male ; Medical sciences ; Ophthalmology ; S100 Proteins - metabolism ; Tomography, X-Ray Computed ; Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus ; Vimentin - metabolism</subject><ispartof>Ophthalmology (Rochester, MN), 1993-06, Vol.100 (6), p.955-960</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c287t-b2c68b71ebcd9baee201c10aff743a7f24fc20bf0830042c95652b9b04b6a3703</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,776,780,785,786,23909,23910,25118,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4773956$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7685513$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ELLIS, F. J</creatorcontrib><creatorcontrib>EAGLE, R. C</creatorcontrib><creatorcontrib>SHIELDS, J. A</creatorcontrib><creatorcontrib>SHIELDS, C. L</creatorcontrib><creatorcontrib>FESSLER, J. N</creatorcontrib><creatorcontrib>TAKEMOTO, L. J</creatorcontrib><title>Phakomatous choristoma (Zimmerman's tumor) : immunohistochemical confirmation of lens-specific proteins</title><title>Ophthalmology (Rochester, MN)</title><addtitle>Ophthalmology</addtitle><description>Phakomatous choristoma is a rare, congenital, ocular adnexal tumor that is presumed to be of lenticular anlage based on light and electron microscopy.
The authors performed immunohistochemistry using standard commercially available antibodies against vimentin, S-100 protein, and several cytokeratins on a phakomatous choristoma that was excised from the right lower eyelid of a 10-week-old white boy. In addition, a battery of antibodies against lens-specific proteins, including alpha, beta, and gamma crystallins, was used.
The tumor cells showed intense immunoreactivity for all lens-specific proteins tested. The epithelial cells of the phakomatous choristoma stained positively for S-100 protein and vimentin, the intermediate filament normally found in lens epithelial cells. Keratin markers were negative.
The results of immunohistochemistry indicate that the cells of phakomatous choristoma synthesize several types of lens-specific proteins. Complementing previous light and electron microscopic studies, these data strongly support Zimmerman's conclusion that this pediatric adnexal tumor is a choristoma of lenticular anlage.</description><subject>Antibodies, Monoclonal</subject><subject>Biological and medical sciences</subject><subject>Choristoma - diagnostic imaging</subject><subject>Choristoma - metabolism</subject><subject>Crystallins - metabolism</subject><subject>Epithelium - pathology</subject><subject>Eyelid Neoplasms - diagnostic imaging</subject><subject>Eyelid Neoplasms - metabolism</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Infant</subject><subject>Keratins - metabolism</subject><subject>Lens, Crystalline</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Ophthalmology</subject><subject>S100 Proteins - metabolism</subject><subject>Tomography, X-Ray Computed</subject><subject>Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus</subject><subject>Vimentin - metabolism</subject><issn>0161-6420</issn><issn>1549-4713</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1LAzEQhoMotVZ_QiEH0fawmq9Ndr1J8QsKCurFy5KkiRvdJHWze_DfG7F4mWHmfZiXdwCYY3SBEeaXz7nggjOCFjVdUlwKWtA9MMUlqwsmMN0H03_kEByl9IEQ4pyyCZgIXpUlplPw_tTKz-jlEMcEdRt7l4Y8wsWb8970XobzBIfRx34Jr2DejSG2v4xujXdadlDHYF0GBxcDjBZ2JqQibY121mm47eNgXEjH4MDKLpmTXZ-B19ubl9V9sX68e1hdrwtNKjEUimheKYGN0ptaSWMIwhojaa1gVApLmNUEKYsqihAjui55SVStEFNcUoHoDJz93c3GX6NJQ-Nd0qbrZDA5YiNKIXDFSAbnO3BU3myabe-87L-b3WeyfrrTZcoxbS-DdukfY0LQbE5_AO0ldQo</recordid><startdate>19930601</startdate><enddate>19930601</enddate><creator>ELLIS, F. J</creator><creator>EAGLE, R. C</creator><creator>SHIELDS, J. A</creator><creator>SHIELDS, C. L</creator><creator>FESSLER, J. N</creator><creator>TAKEMOTO, L. J</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19930601</creationdate><title>Phakomatous choristoma (Zimmerman's tumor) : immunohistochemical confirmation of lens-specific proteins</title><author>ELLIS, F. J ; EAGLE, R. C ; SHIELDS, J. A ; SHIELDS, C. L ; FESSLER, J. N ; TAKEMOTO, L. J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c287t-b2c68b71ebcd9baee201c10aff743a7f24fc20bf0830042c95652b9b04b6a3703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Antibodies, Monoclonal</topic><topic>Biological and medical sciences</topic><topic>Choristoma - diagnostic imaging</topic><topic>Choristoma - metabolism</topic><topic>Crystallins - metabolism</topic><topic>Epithelium - pathology</topic><topic>Eyelid Neoplasms - diagnostic imaging</topic><topic>Eyelid Neoplasms - metabolism</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Infant</topic><topic>Keratins - metabolism</topic><topic>Lens, Crystalline</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Ophthalmology</topic><topic>S100 Proteins - metabolism</topic><topic>Tomography, X-Ray Computed</topic><topic>Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus</topic><topic>Vimentin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ELLIS, F. J</creatorcontrib><creatorcontrib>EAGLE, R. C</creatorcontrib><creatorcontrib>SHIELDS, J. A</creatorcontrib><creatorcontrib>SHIELDS, C. L</creatorcontrib><creatorcontrib>FESSLER, J. N</creatorcontrib><creatorcontrib>TAKEMOTO, L. J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Ophthalmology (Rochester, MN)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ELLIS, F. J</au><au>EAGLE, R. C</au><au>SHIELDS, J. A</au><au>SHIELDS, C. L</au><au>FESSLER, J. N</au><au>TAKEMOTO, L. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phakomatous choristoma (Zimmerman's tumor) : immunohistochemical confirmation of lens-specific proteins</atitle><jtitle>Ophthalmology (Rochester, MN)</jtitle><addtitle>Ophthalmology</addtitle><date>1993-06-01</date><risdate>1993</risdate><volume>100</volume><issue>6</issue><spage>955</spage><epage>960</epage><pages>955-960</pages><issn>0161-6420</issn><eissn>1549-4713</eissn><coden>OPHTDG</coden><abstract>Phakomatous choristoma is a rare, congenital, ocular adnexal tumor that is presumed to be of lenticular anlage based on light and electron microscopy.
The authors performed immunohistochemistry using standard commercially available antibodies against vimentin, S-100 protein, and several cytokeratins on a phakomatous choristoma that was excised from the right lower eyelid of a 10-week-old white boy. In addition, a battery of antibodies against lens-specific proteins, including alpha, beta, and gamma crystallins, was used.
The tumor cells showed intense immunoreactivity for all lens-specific proteins tested. The epithelial cells of the phakomatous choristoma stained positively for S-100 protein and vimentin, the intermediate filament normally found in lens epithelial cells. Keratin markers were negative.
The results of immunohistochemistry indicate that the cells of phakomatous choristoma synthesize several types of lens-specific proteins. Complementing previous light and electron microscopic studies, these data strongly support Zimmerman's conclusion that this pediatric adnexal tumor is a choristoma of lenticular anlage.</abstract><cop>New York, NY</cop><pub>Elsevier</pub><pmid>7685513</pmid><doi>10.1016/S0161-6420(93)31573-3</doi><tpages>6</tpages></addata></record> |
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| ispartof | Ophthalmology (Rochester, MN), 1993-06, Vol.100 (6), p.955-960 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Antibodies, Monoclonal Biological and medical sciences Choristoma - diagnostic imaging Choristoma - metabolism Crystallins - metabolism Epithelium - pathology Eyelid Neoplasms - diagnostic imaging Eyelid Neoplasms - metabolism Humans Immunoenzyme Techniques Infant Keratins - metabolism Lens, Crystalline Male Medical sciences Ophthalmology S100 Proteins - metabolism Tomography, X-Ray Computed Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus Vimentin - metabolism |
| title | Phakomatous choristoma (Zimmerman's tumor) : immunohistochemical confirmation of lens-specific proteins |
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