Ras proteins increase Ca(2+)-responsiveness of smooth muscle contraction

G-proteins may be involved in receptor-mediated Ca(2+)-sensitization of smooth muscle contraction, but the responsible G-proteins are not yet known. Here we show that in beta-escin skinned mesenteric microarteries, H-ras p21 proteins, preactivated with GTP or GTP gamma S, increase force at constant...

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Veröffentlicht in:	FEBS letters 1993-06, Vol.324 (2), p.211-215
Hauptverfasser:	Satoh, S, Rensland, H, Pfitzer, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arterioles - drug effects Calcium - pharmacology Cell Membrane Permeability Dose-Response Relationship, Drug Escin Female Guanosine 5'-O-(3-Thiotriphosphate) - pharmacology Guanosine Triphosphate - pharmacology Guinea Pigs Mesentery - drug effects Muscle Contraction - drug effects Muscle, Smooth, Vascular - drug effects Proto-Oncogene Proteins Proto-Oncogene Proteins p21(ras) - pharmacology
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