Genotypic divergence precedes clinical dissemination in a case of synchronous bilateral B-cell malignant lymphoma of the testes
Malignant lymphoma of the testis occurs bilaterally more often than any other tumor type. We report the case of a 62-year-old man who presented with synchronous, bilateral, testicular malignant lymphomas without clinical or radiologic evidence of extratesticular disease. The patient received no ther...
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| Veröffentlicht in: | Human pathology 1993-06, Vol.24 (6), p.675-678 |
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| creator | Bentley, Ren C. Devlin, Blythe Kaufman, Russell E. Borowitz, Michael Ratech, Howard |
| description | Malignant lymphoma of the testis occurs bilaterally more often than any other tumor type. We report the case of a 62-year-old man who presented with synchronous, bilateral, testicular malignant lymphomas without clinical or radiologic evidence of extratesticular disease. The patient received no therapy other than bilateral orchiectomy and subsequently developed widespread disease 6 months later. Southern blot DNA analysis was performed on the initial orchiectomy samples for immunoglobulin (Ig) gene rearrangements. These genotypic analyses showed different clonal rearrangements in the Ig heavy chain J
H region but identical clonal rearrangements in the Ig light chain C
Kappa region. To our knowledge this is the first genotypic demonstration of a common clonal origin in synchronous, bilateral, testicular malignant lymphomas. We interpret these findings as molecular evidence that the patient's malignant lymphoma was already disseminated at initial presentation, although it was clinically undetectable at that time. |
| doi_str_mv | 10.1016/0046-8177(93)90249-G |
| format | Article |
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H region but identical clonal rearrangements in the Ig light chain C
Kappa region. To our knowledge this is the first genotypic demonstration of a common clonal origin in synchronous, bilateral, testicular malignant lymphomas. We interpret these findings as molecular evidence that the patient's malignant lymphoma was already disseminated at initial presentation, although it was clinically undetectable at that time.</description><identifier>ISSN: 0046-8177</identifier><identifier>EISSN: 1532-8392</identifier><identifier>DOI: 10.1016/0046-8177(93)90249-G</identifier><identifier>PMID: 8505044</identifier><identifier>CODEN: HPCQA4</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Antigens, CD - analysis ; Antigens, Neoplasm - analysis ; bilateral ; Biological and medical sciences ; clonal evolution ; Genotype ; Gynecology. Andrology. Obstetrics ; Humans ; Immunoglobulin G - genetics ; Immunoglobulin Heavy Chains - genetics ; Immunoglobulin Light Chains - genetics ; immunohistochemistry ; Lymphoma, B-Cell - genetics ; Lymphoma, B-Cell - immunology ; Lymphoma, B-Cell - pathology ; Male ; Male genital diseases ; malignant lymphoma ; Medical sciences ; Middle Aged ; Southern blot ; Testicular Neoplasms - genetics ; Testicular Neoplasms - immunology ; Testicular Neoplasms - pathology ; testis ; Tumors</subject><ispartof>Human pathology, 1993-06, Vol.24 (6), p.675-678</ispartof><rights>1993</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-2a4f9f40e6bc0f8e089b37c74149c9d0ce56d79245f34b84c0ae6256a0f103333</citedby><cites>FETCH-LOGICAL-c386t-2a4f9f40e6bc0f8e089b37c74149c9d0ce56d79245f34b84c0ae6256a0f103333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/004681779390249G$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4860796$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8505044$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bentley, Ren C.</creatorcontrib><creatorcontrib>Devlin, Blythe</creatorcontrib><creatorcontrib>Kaufman, Russell E.</creatorcontrib><creatorcontrib>Borowitz, Michael</creatorcontrib><creatorcontrib>Ratech, Howard</creatorcontrib><title>Genotypic divergence precedes clinical dissemination in a case of synchronous bilateral B-cell malignant lymphoma of the testes</title><title>Human pathology</title><addtitle>Hum Pathol</addtitle><description>Malignant lymphoma of the testis occurs bilaterally more often than any other tumor type. We report the case of a 62-year-old man who presented with synchronous, bilateral, testicular malignant lymphomas without clinical or radiologic evidence of extratesticular disease. The patient received no therapy other than bilateral orchiectomy and subsequently developed widespread disease 6 months later. Southern blot DNA analysis was performed on the initial orchiectomy samples for immunoglobulin (Ig) gene rearrangements. These genotypic analyses showed different clonal rearrangements in the Ig heavy chain J
H region but identical clonal rearrangements in the Ig light chain C
Kappa region. To our knowledge this is the first genotypic demonstration of a common clonal origin in synchronous, bilateral, testicular malignant lymphomas. We interpret these findings as molecular evidence that the patient's malignant lymphoma was already disseminated at initial presentation, although it was clinically undetectable at that time.</description><subject>Antigens, CD - analysis</subject><subject>Antigens, Neoplasm - analysis</subject><subject>bilateral</subject><subject>Biological and medical sciences</subject><subject>clonal evolution</subject><subject>Genotype</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Immunoglobulin G - genetics</subject><subject>Immunoglobulin Heavy Chains - genetics</subject><subject>Immunoglobulin Light Chains - genetics</subject><subject>immunohistochemistry</subject><subject>Lymphoma, B-Cell - genetics</subject><subject>Lymphoma, B-Cell - immunology</subject><subject>Lymphoma, B-Cell - pathology</subject><subject>Male</subject><subject>Male genital diseases</subject><subject>malignant lymphoma</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Southern blot</subject><subject>Testicular Neoplasms - genetics</subject><subject>Testicular Neoplasms - immunology</subject><subject>Testicular Neoplasms - pathology</subject><subject>testis</subject><subject>Tumors</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcGL1DAUxoMo67j6HyjkIKKHri9tkjaXBV10VljwoueQpi87kTapSWdhTvuvmzrDHDcEcvi-7-Xj9wh5y-CKAZOfAbisOta2H1XzSUHNVbV9RjZMNHXVNap-TjZny0vyKuc_AIwJLi7IRSdAAOcb8rjFEJfD7C0d_AOmewwW6ZzQ4oCZ2tEHb81YxJxx8sEsPgbqAzXUmow0OpoPwe5SDHGfae9Hs2Aqga-VxXGkkxn9fTBhoeNhmndxMmtk2SFdMJf7mrxwZsz45vRekt_fv_26ua3ufm5_3Hy5q2zTyaWqDXfKcUDZW3AdQqf6prUtZ1xZNYBFIYdW1Vy4hvcdt2BQ1kIacAyaci7Jh-PcOcW_-_K1nnxeG5qApbhuRStVK3gx8qPRpphzQqfn5CeTDpqBXrnrFapeoWrV6P_c9bbE3p3m7_sJh3PoBLro70-6yYWnSyZYn8823klolSy266MNC4sHj0ln69eVDL6sZNFD9E_3-Aet4aCi</recordid><startdate>19930601</startdate><enddate>19930601</enddate><creator>Bentley, Ren C.</creator><creator>Devlin, Blythe</creator><creator>Kaufman, Russell E.</creator><creator>Borowitz, Michael</creator><creator>Ratech, Howard</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930601</creationdate><title>Genotypic divergence precedes clinical dissemination in a case of synchronous bilateral B-cell malignant lymphoma of the testes</title><author>Bentley, Ren C. ; Devlin, Blythe ; Kaufman, Russell E. ; Borowitz, Michael ; Ratech, Howard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-2a4f9f40e6bc0f8e089b37c74149c9d0ce56d79245f34b84c0ae6256a0f103333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Antigens, CD - analysis</topic><topic>Antigens, Neoplasm - analysis</topic><topic>bilateral</topic><topic>Biological and medical sciences</topic><topic>clonal evolution</topic><topic>Genotype</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Immunoglobulin G - genetics</topic><topic>Immunoglobulin Heavy Chains - genetics</topic><topic>Immunoglobulin Light Chains - genetics</topic><topic>immunohistochemistry</topic><topic>Lymphoma, B-Cell - genetics</topic><topic>Lymphoma, B-Cell - immunology</topic><topic>Lymphoma, B-Cell - pathology</topic><topic>Male</topic><topic>Male genital diseases</topic><topic>malignant lymphoma</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Southern blot</topic><topic>Testicular Neoplasms - genetics</topic><topic>Testicular Neoplasms - immunology</topic><topic>Testicular Neoplasms - pathology</topic><topic>testis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bentley, Ren C.</creatorcontrib><creatorcontrib>Devlin, Blythe</creatorcontrib><creatorcontrib>Kaufman, Russell E.</creatorcontrib><creatorcontrib>Borowitz, Michael</creatorcontrib><creatorcontrib>Ratech, Howard</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bentley, Ren C.</au><au>Devlin, Blythe</au><au>Kaufman, Russell E.</au><au>Borowitz, Michael</au><au>Ratech, Howard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genotypic divergence precedes clinical dissemination in a case of synchronous bilateral B-cell malignant lymphoma of the testes</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>1993-06-01</date><risdate>1993</risdate><volume>24</volume><issue>6</issue><spage>675</spage><epage>678</epage><pages>675-678</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><coden>HPCQA4</coden><abstract>Malignant lymphoma of the testis occurs bilaterally more often than any other tumor type. We report the case of a 62-year-old man who presented with synchronous, bilateral, testicular malignant lymphomas without clinical or radiologic evidence of extratesticular disease. The patient received no therapy other than bilateral orchiectomy and subsequently developed widespread disease 6 months later. Southern blot DNA analysis was performed on the initial orchiectomy samples for immunoglobulin (Ig) gene rearrangements. These genotypic analyses showed different clonal rearrangements in the Ig heavy chain J
H region but identical clonal rearrangements in the Ig light chain C
Kappa region. To our knowledge this is the first genotypic demonstration of a common clonal origin in synchronous, bilateral, testicular malignant lymphomas. We interpret these findings as molecular evidence that the patient's malignant lymphoma was already disseminated at initial presentation, although it was clinically undetectable at that time.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8505044</pmid><doi>10.1016/0046-8177(93)90249-G</doi><tpages>4</tpages></addata></record> |
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| ispartof | Human pathology, 1993-06, Vol.24 (6), p.675-678 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Antigens, CD - analysis Antigens, Neoplasm - analysis bilateral Biological and medical sciences clonal evolution Genotype Gynecology. Andrology. Obstetrics Humans Immunoglobulin G - genetics Immunoglobulin Heavy Chains - genetics Immunoglobulin Light Chains - genetics immunohistochemistry Lymphoma, B-Cell - genetics Lymphoma, B-Cell - immunology Lymphoma, B-Cell - pathology Male Male genital diseases malignant lymphoma Medical sciences Middle Aged Southern blot Testicular Neoplasms - genetics Testicular Neoplasms - immunology Testicular Neoplasms - pathology testis Tumors |
| title | Genotypic divergence precedes clinical dissemination in a case of synchronous bilateral B-cell malignant lymphoma of the testes |
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