Effect of interferon-α on immediate early gene expression of murine cytomegalovirus

Interferon-alpha (IFN-alpha) significantly reduced the replication of murine cytomegalovirus (MCMV) in mouse embryo fibroblasts derived from the susceptible mouse strain C3H/HeJ. When infectious virus production was measured, a strong decrease in virus titer was observed in IFN-treated cells at a mu...

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Veröffentlicht in:	Journal of interferon research 1993-04, Vol.13 (2), p.105-109
Hauptverfasser:	MARTINOTTI, M. G, GRIBAUDO, G, GARIGLIO, M, CALIENDO, A, LEMBO, D, ANGERETTI, A, CAVALLO, R, LANDOLFO, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Cytomegalovirus - genetics Female Gene Expression Regulation, Viral - drug effects Immediate-Early Proteins - genetics Interferon-alpha - pharmacology Medical sciences Membrane Glycoproteins Mice Mice, Inbred BALB C Mice, Inbred C3H Pharmacology. Drug treatments RNA, Messenger - biosynthesis Trans-Activators Transcription, Genetic - drug effects Viral Envelope Proteins Viral Proteins - drug effects Viral Proteins - metabolism Virus Replication - drug effects
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