Disturbances in collagen synthesis in trisomic cells from spontaneously aborted embryos

Collagen synthesis in cells with trisomy 7 and 9 derived from human spontaneous abortuses was found to be lower (5.06% and 5.53% respectively) than in the control diploid cells (8.80%). The ratio of collagen types (I/III) in trisomic strains did not differ from the control data while the amount of t...

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Veröffentlicht in:	Human genetics 1984-01, Vol.68 (3), p.269-271
Hauptverfasser:	KUKHARENKO, V. I, DELVIG, A. A, GRINBERG, K. N
Format:	Artikel
Sprache:	eng
Schlagworte:	Abortion, Spontaneous Biological and medical sciences Cells, Cultured Chromosome aberrations Chromosomes, Human, 6-12 and X Collagen - biosynthesis Collagen - genetics Embryo, Mammalian - metabolism Extracellular Matrix - metabolism Female Fibroblasts Humans Male Medical genetics Medical sciences Pregnancy Trisomy
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Beschreibung
Zusammenfassung:	Collagen synthesis in cells with trisomy 7 and 9 derived from human spontaneous abortuses was found to be lower (5.06% and 5.53% respectively) than in the control diploid cells (8.80%). The ratio of collagen types (I/III) in trisomic strains did not differ from the control data while the amount of the degraded procollagen in trisomic cells was increased.
ISSN:	0340-6717 1432-1203
DOI:	10.1007/BF00418401