Wavelength specific patterns of p53 induction in human skin following exposure to UV radiation
We report that, in human skin, exposure to equally erythemogenic doses of UVA, UVB, and UVC increases immunocytochemically detected p53 in a wavelength-specific pattern. UVC produced immunostaining confined to the upper epidermis. With UVB, staining was seen throughout the epidermis, whereas with UV...
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| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 1993-06, Vol.53 (12), p.2697-2699 |
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| container_title | Cancer research (Chicago, Ill.) |
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| creator | CAMPBELL, C QUINN, A. G ANGUS, B FARR, P. M REES, J. L |
| description | We report that, in human skin, exposure to equally erythemogenic doses of UVA, UVB, and UVC increases immunocytochemically detected p53 in a wavelength-specific pattern. UVC produced immunostaining confined to the upper epidermis. With UVB, staining was seen throughout the epidermis, whereas with UVA staining predominated in the basal layer. The results with UVB and UVC are understandable on the basis of their known differences in penetration, whereas those with UVA are not. This suggests that within one cell type the pattern of p53 response to UV radiation is wavelength dependent. |
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| source | MEDLINE; American Association for Cancer Research; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Gene Expression - radiation effects Genes, p53 - radiation effects Humans Male Medical sciences Middle Aged Physical agents Skin - chemistry Skin - radiation effects Tumor Suppressor Protein p53 - analysis Tumors Ultraviolet Rays - classification |
| title | Wavelength specific patterns of p53 induction in human skin following exposure to UV radiation |
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