Beneficial effect of EPC-K1 on the survival of warm ischemic damaged graft in rat cardiac transplantation

A newly introduced compound, EPC-K1, represents a phosphate diester linkage of vitamin E and vitamin C. The effect of EPC-K1 on the reperfusion injury was evaluated in a heterotopic cardiac transplantation model using syngenic combination rats. Prior to the warm ischemia, 12mg EPC-K1/kg was administ...

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Veröffentlicht in:	Acta medica Okayama 1993-04, Vol.47 (2), p.121-127
Hauptverfasser:	Tanemoto, K, Sakagami, K, Orita, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ascorbic Acid - analogs & derivatives Ascorbic Acid - pharmacology Free Radical Scavengers Graft Survival - drug effects Heart Transplantation - pathology Hot Temperature Male Molecular Weight Myocardial Reperfusion Injury - prevention & control Rats Rats, Wistar Thiobarbituric Acid Reactive Substances - metabolism Vitamin E - analogs & derivatives Vitamin E - pharmacology
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