RNA recognition by an isolated α helix

A 17 amino acid peptide containing the arginine-rich region of the HIV Rev protein binds specifically to Rev response element (RRE) RNA. Even though it is highly charged, the peptide forms an α helix in solution, but only when its N- and C-termini are modified to provide favorable electrostatic inte...

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Bibliographische Detailangaben
Veröffentlicht in:	Cell 1993-06, Vol.73 (5), p.1031-1040
Hauptverfasser:	Tan, Ruoying, Chen, Lily, Buettner, Joseph A., Hudson, Derek, Frankel, Alan D.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Amino Acid Sequence Arginine Base Sequence Biological and medical sciences Fundamental and applied biological sciences. Psychology Gene Products, rev - chemistry HIV-1 - chemistry human immunodeficiency virus Interactions. Associations Intermolecular phenomena Molecular biophysics Molecular Sequence Data Nucleic Acid Conformation Proline Protein Structure, Secondary Regulatory Sequences, Nucleic Acid rev Gene Products, Human Immunodeficiency Virus RNA - metabolism RNA-Binding Proteins - chemistry
Online-Zugang:	Volltext
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