The platelet benzodiazepine receptor is unaltered in obsessive-compulsive disorder
Mitochondrial benzodiazepine receptors (MBR) are sensitive to anxiety and stress. The aim of the present study was to investigate whether platelet MBR are altered in untreated obsessive-compulsive disorder (OCD) patients and whether chronic treatment with clomipramine (CMI) regulates these receptors...
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| Veröffentlicht in: | Clinical neuropharmacology 1993-06, Vol.16 (3), p.211-215 |
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| container_title | Clinical neuropharmacology |
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| creator | WEIZMAN, R HERMESH, H KARP, L DAR, D. E MUNITZ, H GAVISH, M |
| description | Mitochondrial benzodiazepine receptors (MBR) are sensitive to anxiety and stress. The aim of the present study was to investigate whether platelet MBR are altered in untreated obsessive-compulsive disorder (OCD) patients and whether chronic treatment with clomipramine (CMI) regulates these receptors. MBR were assessed in 13 drug-free OCD patients as compared with 15 healthy controls. Seven of the 13 patients were treated with CMI (200-300 mg/day). The density and affinity of the receptors to their ligand [3H]PK 11195 in OCD patients and controls were not affected by the CMI treatment despite the clinical improvement. It seems that, in contrast to generalized anxiety disorder, OCD is not associated with alterations in platelet benzodiazepine receptors. |
| doi_str_mv | 10.1097/00002826-199306000-00004 |
| format | Article |
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It seems that, in contrast to generalized anxiety disorder, OCD is not associated with alterations in platelet benzodiazepine receptors.</description><identifier>ISSN: 0362-5664</identifier><identifier>EISSN: 1537-162X</identifier><identifier>DOI: 10.1097/00002826-199306000-00004</identifier><identifier>PMID: 8389247</identifier><identifier>CODEN: CLNEDB</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Adult ; Biological and medical sciences ; Blood Platelets - drug effects ; Blood Platelets - metabolism ; Clomipramine - pharmacology ; Female ; Humans ; Isoquinolines - metabolism ; Male ; Medical sciences ; Middle Aged ; Mitochondria - drug effects ; Mitochondria - metabolism ; Neuropharmacology ; Obsessive-Compulsive Disorder - blood ; Pharmacology. Drug treatments ; Psycholeptics: tranquillizer, neuroleptic ; Psychology. Psychoanalysis. 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E</creatorcontrib><creatorcontrib>MUNITZ, H</creatorcontrib><creatorcontrib>GAVISH, M</creatorcontrib><title>The platelet benzodiazepine receptor is unaltered in obsessive-compulsive disorder</title><title>Clinical neuropharmacology</title><addtitle>Clin Neuropharmacol</addtitle><description>Mitochondrial benzodiazepine receptors (MBR) are sensitive to anxiety and stress. The aim of the present study was to investigate whether platelet MBR are altered in untreated obsessive-compulsive disorder (OCD) patients and whether chronic treatment with clomipramine (CMI) regulates these receptors. MBR were assessed in 13 drug-free OCD patients as compared with 15 healthy controls. Seven of the 13 patients were treated with CMI (200-300 mg/day). The density and affinity of the receptors to their ligand [3H]PK 11195 in OCD patients and controls were not affected by the CMI treatment despite the clinical improvement. It seems that, in contrast to generalized anxiety disorder, OCD is not associated with alterations in platelet benzodiazepine receptors.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Platelets - drug effects</subject><subject>Blood Platelets - metabolism</subject><subject>Clomipramine - pharmacology</subject><subject>Female</subject><subject>Humans</subject><subject>Isoquinolines - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mitochondria - drug effects</subject><subject>Mitochondria - metabolism</subject><subject>Neuropharmacology</subject><subject>Obsessive-Compulsive Disorder - blood</subject><subject>Pharmacology. Drug treatments</subject><subject>Psycholeptics: tranquillizer, neuroleptic</subject><subject>Psychology. Psychoanalysis. 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Psychiatry</topic><topic>Psychopharmacology</topic><topic>Radioligand Assay</topic><topic>Receptors, GABA-A - drug effects</topic><topic>Receptors, GABA-A - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WEIZMAN, R</creatorcontrib><creatorcontrib>HERMESH, H</creatorcontrib><creatorcontrib>KARP, L</creatorcontrib><creatorcontrib>DAR, D. 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E</au><au>MUNITZ, H</au><au>GAVISH, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The platelet benzodiazepine receptor is unaltered in obsessive-compulsive disorder</atitle><jtitle>Clinical neuropharmacology</jtitle><addtitle>Clin Neuropharmacol</addtitle><date>1993-06-01</date><risdate>1993</risdate><volume>16</volume><issue>3</issue><spage>211</spage><epage>215</epage><pages>211-215</pages><issn>0362-5664</issn><eissn>1537-162X</eissn><coden>CLNEDB</coden><abstract>Mitochondrial benzodiazepine receptors (MBR) are sensitive to anxiety and stress. The aim of the present study was to investigate whether platelet MBR are altered in untreated obsessive-compulsive disorder (OCD) patients and whether chronic treatment with clomipramine (CMI) regulates these receptors. MBR were assessed in 13 drug-free OCD patients as compared with 15 healthy controls. Seven of the 13 patients were treated with CMI (200-300 mg/day). The density and affinity of the receptors to their ligand [3H]PK 11195 in OCD patients and controls were not affected by the CMI treatment despite the clinical improvement. It seems that, in contrast to generalized anxiety disorder, OCD is not associated with alterations in platelet benzodiazepine receptors.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>8389247</pmid><doi>10.1097/00002826-199306000-00004</doi><tpages>5</tpages></addata></record> |
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| ispartof | Clinical neuropharmacology, 1993-06, Vol.16 (3), p.211-215 |
| issn | 0362-5664 1537-162X |
| language | eng |
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| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Adult Biological and medical sciences Blood Platelets - drug effects Blood Platelets - metabolism Clomipramine - pharmacology Female Humans Isoquinolines - metabolism Male Medical sciences Middle Aged Mitochondria - drug effects Mitochondria - metabolism Neuropharmacology Obsessive-Compulsive Disorder - blood Pharmacology. Drug treatments Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Radioligand Assay Receptors, GABA-A - drug effects Receptors, GABA-A - metabolism |
| title | The platelet benzodiazepine receptor is unaltered in obsessive-compulsive disorder |
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