Orally active water-soluble N,O-acyl transfer products of a .beta.,.gamma.-bishydroxyl amide containing renin inhibitor
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Veröffentlicht in: | Journal of medicinal chemistry 1993-05, Vol.36 (10), p.1496-1498 |
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container_end_page | 1498 |
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container_issue | 10 |
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container_title | Journal of medicinal chemistry |
container_volume | 36 |
creator | Hurley, Timothy R Colson, Charles E Hicks, Gary Ryan, Michael J |
description | |
doi_str_mv | 10.1021/jm00062a024 |
format | Article |
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Med. Chem</addtitle><subject>Administration, Oral</subject><subject>Amides - chemical synthesis</subject><subject>Amides - pharmacokinetics</subject><subject>Amides - pharmacology</subject><subject>Animals</subject><subject>Antihypertensive agents</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular system</subject><subject>Macaca fascicularis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Renin - antagonists & inhibitors</subject><subject>Solubility</subject><subject>Structure-Activity Relationship</subject><issn>0022-2623</issn><issn>1520-4804</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkEtrFEEUhQtR4hhduRZqIbow3darX0sJGoXgCIkg2RS3XkmN3V1JVbXJ_HsrzDC4cHUX57uHw4fQa0pqShj9uJkIIS0DwsQTtKINI5XoiXiKVoQwVrGW8efoRUqbgnHK-BE66sXQDrRfoft1hHHcYtDZ_7H4HrKNVQrjokaLv5-sK9DbEecIc3I24tsYzKJzwsFhwLWyGeqT-hqmCepK-XSzNTE8lA-YvLFYhzmDn_18jaMtB_v5xiufQ3yJnjkYk321v8fo55fPl6dfq_P12bfTT-cVCDHksp2YzkGvKde9EK51rRFUgeDMUVDcDMYJC8OgNFOEDGQwAoRutKGKUcH5MXq36y3L7xabspx80nYcYbZhSbJrupb3bV_ADztQx5BStE7eRj9B3EpK5KNm-Y_mQr_Z1y5qsubA7r2W_O0-h6RhdMWf9umAiZ6Shj6uq3aYT9k-HGKIv2Xb8a6Rlz8u5BVt-Rm7uJK_Cv9-x4NOchOWOBd3_x34F2uEoU8</recordid><startdate>199305</startdate><enddate>199305</enddate><creator>Hurley, Timothy R</creator><creator>Colson, Charles E</creator><creator>Hicks, Gary</creator><creator>Ryan, Michael J</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199305</creationdate><title>Orally active water-soluble N,O-acyl transfer products of a .beta.,.gamma.-bishydroxyl amide containing renin inhibitor</title><author>Hurley, Timothy R ; Colson, Charles E ; Hicks, Gary ; Ryan, Michael J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a449t-260d7fa8c13c844f6f6d41ba432f1ab3d9df4ea99bc2b00909d4a4c5cd1b21433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Administration, Oral</topic><topic>Amides - chemical synthesis</topic><topic>Amides - pharmacokinetics</topic><topic>Amides - pharmacology</topic><topic>Animals</topic><topic>Antihypertensive agents</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular system</topic><topic>Macaca fascicularis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. 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ispartof | Journal of medicinal chemistry, 1993-05, Vol.36 (10), p.1496-1498 |
issn | 0022-2623 1520-4804 |
language | eng |
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source | MEDLINE; American Chemical Society Publications |
subjects | Administration, Oral Amides - chemical synthesis Amides - pharmacokinetics Amides - pharmacology Animals Antihypertensive agents Biological and medical sciences Cardiovascular system Macaca fascicularis Male Medical sciences Pharmacology. Drug treatments Renin - antagonists & inhibitors Solubility Structure-Activity Relationship |
title | Orally active water-soluble N,O-acyl transfer products of a .beta.,.gamma.-bishydroxyl amide containing renin inhibitor |
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