Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis

To date, the potency of pancreatic and duodenal homeobox gene 1 (PDX-1) in inducing differentiation into insulin-producing cells has been demonstrated in some cells and tissues. In order to carry out efficient screening of somatic tissues and cells that can transdifferentiate into β-cell-like cells...

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Veröffentlicht in:	Biochemical and biophysical research communications 2003-10, Vol.310 (3), p.1017-1025
Hauptverfasser:	Miyatsuka, T, Kaneto, H, Kajimoto, Y, Hirota, S, Arakawa, Y, Fujitani, Y, Umayahara, Y, Watada, H, Yamasaki, Y, Magnuson, M.A, Miyazaki, J, Hori, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Body Weight Cell Differentiation Cell Division Chickens Cre recombinase Differentiation Dysmorphogenesis Endocrine System - metabolism Gene therapy Genetic Therapy - methods Homeodomain Proteins Immunohistochemistry Insulin - metabolism Integrases - metabolism Liver Liver - metabolism LoxP Mice Mice, Transgenic Models, Genetic Pancreas Pancreas - metabolism PDX-1 Peptides - chemistry Polymerase Chain Reaction Promoter Regions, Genetic Recombination, Genetic Reverse Transcriptase Polymerase Chain Reaction RNA - metabolism Time Factors Tissue Distribution Trans-Activators - biosynthesis Trans-Activators - physiology Transgenes Viral Proteins - metabolism
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