Epidermal growth factor receptor and c-erbB-2 contents in unresectable (UICC R1 or R2) gastric cancer
Epidermal growth factor receptor (EGFR) and c-erbB-2 are membrane receptors expressed in a variety of solid human cancers and directly correlated with poor prognosis. The objective of this work was to evaluate the EGFR and c-erbB-2 levels in non-resectable gastric carcinomas, their possible relation...
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| creator | GARCIA, I DEL CASAR, J. M CORTE, M. D ALLENDE, M. T GARCIA-MUNIZ, J. L VIZOSO, F |
| description | Epidermal growth factor receptor (EGFR) and c-erbB-2 are membrane receptors expressed in a variety of solid human cancers and directly correlated with poor prognosis. The objective of this work was to evaluate the EGFR and c-erbB-2 levels in non-resectable gastric carcinomas, their possible relationship with a variety of clinicopathological tumor parameters, and their prognostic significance.
This was a prospective analysis of 65 patients with unresectable gastric carcinomas (UICC R1 or R2), who underwent palliative surgery and were followed up for a median period of 13 months. Membranous EGFR levels were examined by radioligand binding assays and cytosolic c-erbB-2 levels by means of an immunoenzymatic assay.
There was a wide variability in EGFR (80.3-2910 fmol/mg of protein) and c-erbB-2 (0.4-10071 NHU/mg of protein) levels in neoplastic tissues from patients with unresectable gastric carcinomas. Median c-erbB2 was significantly higher in tumors of the intestinal type than in tumors of the diffuse type (p = 0.035) and in R2 than in R1 tumors (p = 0.016). Statistical analysis showed that there was no relationship between tumor c-erbB-2 or EGFR content and any other patient or tumor characteristics. However, high levels of EGFR were significantly associated with a shorter overall survival (p = 0.01).
Our data suggest a role of both transmembrane proteins in the progression of gastric cancer. EGFR and c-erbB-2 contents in unresectable gastric cancer could be utilized as appropriate biological markers for selecting candidates for treatment based on EGFR and/or c-erbB-2 inhibition. |
| doi_str_mv | 10.1177/172460080301800308 |
| format | Article |
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This was a prospective analysis of 65 patients with unresectable gastric carcinomas (UICC R1 or R2), who underwent palliative surgery and were followed up for a median period of 13 months. Membranous EGFR levels were examined by radioligand binding assays and cytosolic c-erbB-2 levels by means of an immunoenzymatic assay.
There was a wide variability in EGFR (80.3-2910 fmol/mg of protein) and c-erbB-2 (0.4-10071 NHU/mg of protein) levels in neoplastic tissues from patients with unresectable gastric carcinomas. Median c-erbB2 was significantly higher in tumors of the intestinal type than in tumors of the diffuse type (p = 0.035) and in R2 than in R1 tumors (p = 0.016). Statistical analysis showed that there was no relationship between tumor c-erbB-2 or EGFR content and any other patient or tumor characteristics. However, high levels of EGFR were significantly associated with a shorter overall survival (p = 0.01).
Our data suggest a role of both transmembrane proteins in the progression of gastric cancer. EGFR and c-erbB-2 contents in unresectable gastric cancer could be utilized as appropriate biological markers for selecting candidates for treatment based on EGFR and/or c-erbB-2 inhibition.</description><identifier>ISSN: 0393-6155</identifier><identifier>EISSN: 1724-6008</identifier><identifier>DOI: 10.1177/172460080301800308</identifier><identifier>PMID: 14535591</identifier><language>eng</language><publisher>Milano: Wichtig</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biomarkers, Tumor ; Carcinoma - metabolism ; Carcinoma - mortality ; Cytosol - metabolism ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Immunoassay ; Male ; Medical sciences ; Middle Aged ; Prognosis ; Prospective Studies ; Radioligand Assay ; Receptor, Epidermal Growth Factor - biosynthesis ; Receptor, ErbB-2 - biosynthesis ; Stomach Neoplasms - genetics ; Stomach Neoplasms - metabolism ; Stomach Neoplasms - mortality ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Time Factors ; Tumors</subject><ispartof>The International journal of biological markers, 2003-07, Vol.18 (3), p.200-206</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c305t-3f6d52cf5854c9874f19dc94a4292ad0a0fdab2de4717d96fc7f65ee323163e63</citedby><cites>FETCH-LOGICAL-c305t-3f6d52cf5854c9874f19dc94a4292ad0a0fdab2de4717d96fc7f65ee323163e63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15158308$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14535591$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GARCIA, I</creatorcontrib><creatorcontrib>DEL CASAR, J. M</creatorcontrib><creatorcontrib>CORTE, M. D</creatorcontrib><creatorcontrib>ALLENDE, M. T</creatorcontrib><creatorcontrib>GARCIA-MUNIZ, J. L</creatorcontrib><creatorcontrib>VIZOSO, F</creatorcontrib><title>Epidermal growth factor receptor and c-erbB-2 contents in unresectable (UICC R1 or R2) gastric cancer</title><title>The International journal of biological markers</title><addtitle>Int J Biol Markers</addtitle><description>Epidermal growth factor receptor (EGFR) and c-erbB-2 are membrane receptors expressed in a variety of solid human cancers and directly correlated with poor prognosis. The objective of this work was to evaluate the EGFR and c-erbB-2 levels in non-resectable gastric carcinomas, their possible relationship with a variety of clinicopathological tumor parameters, and their prognostic significance.
This was a prospective analysis of 65 patients with unresectable gastric carcinomas (UICC R1 or R2), who underwent palliative surgery and were followed up for a median period of 13 months. Membranous EGFR levels were examined by radioligand binding assays and cytosolic c-erbB-2 levels by means of an immunoenzymatic assay.
There was a wide variability in EGFR (80.3-2910 fmol/mg of protein) and c-erbB-2 (0.4-10071 NHU/mg of protein) levels in neoplastic tissues from patients with unresectable gastric carcinomas. Median c-erbB2 was significantly higher in tumors of the intestinal type than in tumors of the diffuse type (p = 0.035) and in R2 than in R1 tumors (p = 0.016). Statistical analysis showed that there was no relationship between tumor c-erbB-2 or EGFR content and any other patient or tumor characteristics. However, high levels of EGFR were significantly associated with a shorter overall survival (p = 0.01).
Our data suggest a role of both transmembrane proteins in the progression of gastric cancer. EGFR and c-erbB-2 contents in unresectable gastric cancer could be utilized as appropriate biological markers for selecting candidates for treatment based on EGFR and/or c-erbB-2 inhibition.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor</subject><subject>Carcinoma - metabolism</subject><subject>Carcinoma - mortality</subject><subject>Cytosol - metabolism</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Immunoassay</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Radioligand Assay</subject><subject>Receptor, Epidermal Growth Factor - biosynthesis</subject><subject>Receptor, ErbB-2 - biosynthesis</subject><subject>Stomach Neoplasms - genetics</subject><subject>Stomach Neoplasms - metabolism</subject><subject>Stomach Neoplasms - mortality</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Time Factors</subject><subject>Tumors</subject><issn>0393-6155</issn><issn>1724-6008</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkEtLxDAUhYMozjj6B1xINoouqnk0SbvUMurAgDA465ImN2OljzFpEf-9LRZm4ebey-E7B-5B6JKSe0qVeqCKxZKQhHBCEzLM5AjNRzEa1WM0JzzlkaRCzNBZCJ-EMEqUPEUzGgsuRErnCJb70oKvdYV3vv3uPrDTpms99mBgPx66sdhE4IuniGHTNh00XcBlg_vGQwDT6aICfLtdZRneUDw4NuwO73TofGmw0Y0Bf45OnK4CXEx7gbbPy_fsNVq_vayyx3VkOBFdxJ20ghknEhGbNFGxo6k1aaxjljJtiSbO6oJZiBVVNpXOKCcFAGecSg6SL9DNX-7et189hC6vy2CgqnQDbR9yJZSkKU8GkP2BxrcheHD53pe19j85JflYbv6_3MF0NaX3RQ32YJnaHIDrCdDB6Mr54fkyHDhBRTIG_QJ-TH-5</recordid><startdate>20030701</startdate><enddate>20030701</enddate><creator>GARCIA, I</creator><creator>DEL CASAR, J. M</creator><creator>CORTE, M. D</creator><creator>ALLENDE, M. T</creator><creator>GARCIA-MUNIZ, J. 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L ; VIZOSO, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c305t-3f6d52cf5854c9874f19dc94a4292ad0a0fdab2de4717d96fc7f65ee323163e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor</topic><topic>Carcinoma - metabolism</topic><topic>Carcinoma - mortality</topic><topic>Cytosol - metabolism</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Immunoassay</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Radioligand Assay</topic><topic>Receptor, Epidermal Growth Factor - biosynthesis</topic><topic>Receptor, ErbB-2 - biosynthesis</topic><topic>Stomach Neoplasms - genetics</topic><topic>Stomach Neoplasms - metabolism</topic><topic>Stomach Neoplasms - mortality</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Time Factors</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GARCIA, I</creatorcontrib><creatorcontrib>DEL CASAR, J. M</creatorcontrib><creatorcontrib>CORTE, M. D</creatorcontrib><creatorcontrib>ALLENDE, M. T</creatorcontrib><creatorcontrib>GARCIA-MUNIZ, J. L</creatorcontrib><creatorcontrib>VIZOSO, F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The International journal of biological markers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GARCIA, I</au><au>DEL CASAR, J. M</au><au>CORTE, M. D</au><au>ALLENDE, M. T</au><au>GARCIA-MUNIZ, J. L</au><au>VIZOSO, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidermal growth factor receptor and c-erbB-2 contents in unresectable (UICC R1 or R2) gastric cancer</atitle><jtitle>The International journal of biological markers</jtitle><addtitle>Int J Biol Markers</addtitle><date>2003-07-01</date><risdate>2003</risdate><volume>18</volume><issue>3</issue><spage>200</spage><epage>206</epage><pages>200-206</pages><issn>0393-6155</issn><eissn>1724-6008</eissn><abstract>Epidermal growth factor receptor (EGFR) and c-erbB-2 are membrane receptors expressed in a variety of solid human cancers and directly correlated with poor prognosis. The objective of this work was to evaluate the EGFR and c-erbB-2 levels in non-resectable gastric carcinomas, their possible relationship with a variety of clinicopathological tumor parameters, and their prognostic significance.
This was a prospective analysis of 65 patients with unresectable gastric carcinomas (UICC R1 or R2), who underwent palliative surgery and were followed up for a median period of 13 months. Membranous EGFR levels were examined by radioligand binding assays and cytosolic c-erbB-2 levels by means of an immunoenzymatic assay.
There was a wide variability in EGFR (80.3-2910 fmol/mg of protein) and c-erbB-2 (0.4-10071 NHU/mg of protein) levels in neoplastic tissues from patients with unresectable gastric carcinomas. Median c-erbB2 was significantly higher in tumors of the intestinal type than in tumors of the diffuse type (p = 0.035) and in R2 than in R1 tumors (p = 0.016). Statistical analysis showed that there was no relationship between tumor c-erbB-2 or EGFR content and any other patient or tumor characteristics. However, high levels of EGFR were significantly associated with a shorter overall survival (p = 0.01).
Our data suggest a role of both transmembrane proteins in the progression of gastric cancer. EGFR and c-erbB-2 contents in unresectable gastric cancer could be utilized as appropriate biological markers for selecting candidates for treatment based on EGFR and/or c-erbB-2 inhibition.</abstract><cop>Milano</cop><pub>Wichtig</pub><pmid>14535591</pmid><doi>10.1177/172460080301800308</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Biomarkers, Tumor Carcinoma - metabolism Carcinoma - mortality Cytosol - metabolism Female Gastroenterology. Liver. Pancreas. Abdomen Humans Immunoassay Male Medical sciences Middle Aged Prognosis Prospective Studies Radioligand Assay Receptor, Epidermal Growth Factor - biosynthesis Receptor, ErbB-2 - biosynthesis Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - mortality Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Time Factors Tumors |
| title | Epidermal growth factor receptor and c-erbB-2 contents in unresectable (UICC R1 or R2) gastric cancer |
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