Effects of vanadyl sulfate on kidney in experimental diabetes
The aim of this work was to investigate the biochemical and histological effects of vanadyl sulfate on blood glucose, urea, and creatinine in serum and nonenzymatic glycosylation and glutathione levels in kidney tissue of normal and streptozotocin (65 mg/kg) diabetic rats. Vanadyl sulfate was admini...
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| Veröffentlicht in: | Biological trace element research 2003-10, Vol.95 (1), p.73-86 |
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| creator | Yanardag, Refiye Bolkent, Sehnaz Karabulut-Bulan, Omür Tunali, Sevim |
| description | The aim of this work was to investigate the biochemical and histological effects of vanadyl sulfate on blood glucose, urea, and creatinine in serum and nonenzymatic glycosylation and glutathione levels in kidney tissue of normal and streptozotocin (65 mg/kg) diabetic rats. Vanadyl sulfate was administered by gavage at a dose of 100 mg/kg. After 60 d of treatment, serum urea, creatinine, and blood glucose levels significantly increased in the diabetic group but not so in the vanadyl sulfate, which showed significantly reduced serum urea and blood glucose levels and a nonsignificant reduction of serum creatinine levels. Nonenzymatic glycosylation was increased and the glutathione level was decreased in the kidney tissue of diabetic rats. Treatment with vanadyl sulfate reversed these effects. Degenerative changes were detected in diabetic animals by electron and light microscopy. Although there are individual differences in diabetic animals given vanadium, some reduction of degenerative changes were observed. |
| doi_str_mv | 10.1385/BTER:95:1:73 |
| format | Article |
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Vanadyl sulfate was administered by gavage at a dose of 100 mg/kg. After 60 d of treatment, serum urea, creatinine, and blood glucose levels significantly increased in the diabetic group but not so in the vanadyl sulfate, which showed significantly reduced serum urea and blood glucose levels and a nonsignificant reduction of serum creatinine levels. Nonenzymatic glycosylation was increased and the glutathione level was decreased in the kidney tissue of diabetic rats. Treatment with vanadyl sulfate reversed these effects. Degenerative changes were detected in diabetic animals by electron and light microscopy. Although there are individual differences in diabetic animals given vanadium, some reduction of degenerative changes were observed.</description><identifier>ISSN: 0163-4984</identifier><identifier>EISSN: 0163-4984</identifier><identifier>EISSN: 1559-0720</identifier><identifier>DOI: 10.1385/BTER:95:1:73</identifier><identifier>PMID: 14555801</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Animals ; Blood ; Blood Glucose - drug effects ; Blood Glucose - metabolism ; Creatinine - blood ; Diabetes ; Diabetes Mellitus, Experimental - drug therapy ; Diabetes Mellitus, Experimental - metabolism ; Fructose - metabolism ; Glutathione - metabolism ; Glycosylation - drug effects ; Hypoglycemic Agents - pharmacology ; Kidney - drug effects ; Kidney - metabolism ; Kidney - ultrastructure ; Kidneys ; Light microscopy ; Male ; Microscopy, Electron ; Rats ; Rodents ; Sulfates ; Tissues ; Urea ; Urea - blood ; Vanadium ; Vanadium Compounds - pharmacology</subject><ispartof>Biological trace element research, 2003-10, Vol.95 (1), p.73-86</ispartof><rights>Humana Press Inc. 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c314t-e5237e798825f0e63b52beae1315bf5c37c1c658c36bf5b9a0c0c98bdbb800cd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14555801$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yanardag, Refiye</creatorcontrib><creatorcontrib>Bolkent, Sehnaz</creatorcontrib><creatorcontrib>Karabulut-Bulan, Omür</creatorcontrib><creatorcontrib>Tunali, Sevim</creatorcontrib><title>Effects of vanadyl sulfate on kidney in experimental diabetes</title><title>Biological trace element research</title><addtitle>Biol Trace Elem Res</addtitle><description>The aim of this work was to investigate the biochemical and histological effects of vanadyl sulfate on blood glucose, urea, and creatinine in serum and nonenzymatic glycosylation and glutathione levels in kidney tissue of normal and streptozotocin (65 mg/kg) diabetic rats. Vanadyl sulfate was administered by gavage at a dose of 100 mg/kg. After 60 d of treatment, serum urea, creatinine, and blood glucose levels significantly increased in the diabetic group but not so in the vanadyl sulfate, which showed significantly reduced serum urea and blood glucose levels and a nonsignificant reduction of serum creatinine levels. Nonenzymatic glycosylation was increased and the glutathione level was decreased in the kidney tissue of diabetic rats. Treatment with vanadyl sulfate reversed these effects. Degenerative changes were detected in diabetic animals by electron and light microscopy. Although there are individual differences in diabetic animals given vanadium, some reduction of degenerative changes were observed.</description><subject>Animals</subject><subject>Blood</subject><subject>Blood Glucose - drug effects</subject><subject>Blood Glucose - metabolism</subject><subject>Creatinine - blood</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Fructose - metabolism</subject><subject>Glutathione - metabolism</subject><subject>Glycosylation - drug effects</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Kidney - ultrastructure</subject><subject>Kidneys</subject><subject>Light microscopy</subject><subject>Male</subject><subject>Microscopy, Electron</subject><subject>Rats</subject><subject>Rodents</subject><subject>Sulfates</subject><subject>Tissues</subject><subject>Urea</subject><subject>Urea - 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drug effects</topic><topic>Blood Glucose - metabolism</topic><topic>Creatinine - blood</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Diabetes Mellitus, Experimental - metabolism</topic><topic>Fructose - metabolism</topic><topic>Glutathione - metabolism</topic><topic>Glycosylation - drug effects</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Kidney - ultrastructure</topic><topic>Kidneys</topic><topic>Light microscopy</topic><topic>Male</topic><topic>Microscopy, Electron</topic><topic>Rats</topic><topic>Rodents</topic><topic>Sulfates</topic><topic>Tissues</topic><topic>Urea</topic><topic>Urea - blood</topic><topic>Vanadium</topic><topic>Vanadium Compounds - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yanardag, Refiye</creatorcontrib><creatorcontrib>Bolkent, Sehnaz</creatorcontrib><creatorcontrib>Karabulut-Bulan, Omür</creatorcontrib><creatorcontrib>Tunali, Sevim</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Aqualine</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Oceanic Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Biological trace element research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yanardag, Refiye</au><au>Bolkent, Sehnaz</au><au>Karabulut-Bulan, Omür</au><au>Tunali, Sevim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of vanadyl sulfate on kidney in experimental diabetes</atitle><jtitle>Biological trace element research</jtitle><addtitle>Biol Trace Elem Res</addtitle><date>2003-10-01</date><risdate>2003</risdate><volume>95</volume><issue>1</issue><spage>73</spage><epage>86</epage><pages>73-86</pages><issn>0163-4984</issn><eissn>0163-4984</eissn><eissn>1559-0720</eissn><abstract>The aim of this work was to investigate the biochemical and histological effects of vanadyl sulfate on blood glucose, urea, and creatinine in serum and nonenzymatic glycosylation and glutathione levels in kidney tissue of normal and streptozotocin (65 mg/kg) diabetic rats. Vanadyl sulfate was administered by gavage at a dose of 100 mg/kg. After 60 d of treatment, serum urea, creatinine, and blood glucose levels significantly increased in the diabetic group but not so in the vanadyl sulfate, which showed significantly reduced serum urea and blood glucose levels and a nonsignificant reduction of serum creatinine levels. Nonenzymatic glycosylation was increased and the glutathione level was decreased in the kidney tissue of diabetic rats. Treatment with vanadyl sulfate reversed these effects. Degenerative changes were detected in diabetic animals by electron and light microscopy. Although there are individual differences in diabetic animals given vanadium, some reduction of degenerative changes were observed.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>14555801</pmid><doi>10.1385/BTER:95:1:73</doi><tpages>14</tpages></addata></record> |
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| subjects | Animals Blood Blood Glucose - drug effects Blood Glucose - metabolism Creatinine - blood Diabetes Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Fructose - metabolism Glutathione - metabolism Glycosylation - drug effects Hypoglycemic Agents - pharmacology Kidney - drug effects Kidney - metabolism Kidney - ultrastructure Kidneys Light microscopy Male Microscopy, Electron Rats Rodents Sulfates Tissues Urea Urea - blood Vanadium Vanadium Compounds - pharmacology |
| title | Effects of vanadyl sulfate on kidney in experimental diabetes |
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