Phosphonooxymethyl prodrugs of the broad spectrum antifungal azole, ravuconazole: Synthesis and biological properties

Synthesis of phosphonooxymethyl derivatives of ravuconazole, 2 (BMS-379224) and 3 (BMS-315801) and their biological evaluation as potential water-soluble prodrugs of ravuconazole are described. The phosphonooxymethyl ether analogue 2 (BMS-379224) and N-phosphonooxymethyl triazolium salt 3 (BMS-31580...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2003-11, Vol.13 (21), p.3669-3672
Hauptverfasser:	UEDA, Yasutsugu, MATISKELLA, John D, VARIA, Sailesh, KNIPE, Jay, MING ZHENG, MATHEW, Marina, MOSURE, Kathy, CLARK, Junius, LAMB, Lucinda, MEDIN, Ivette, QI GAO, HUANG, Stella, GOLIK, Jerzy, CHEN, Chung-Pin, BRONSON, Joanne J, CONNOLLY, Timothy P, HUDYMA, Thomas W, VENKATESH, Srini, DALI, Mandar, KANG, Shin-Hong, BARBOUR, Nancy, TEJWANI, Ravi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - chemical synthesis Antifungal Agents - pharmacokinetics Antifungal Agents - pharmacology Biological and medical sciences Candidiasis - drug therapy Candidiasis - microbiology Drug Stability Female Humans Indicators and Reagents Infusions, Intravenous Medical sciences Mice Mice, Inbred ICR Pharmacology. Drug treatments Prodrugs - chemical synthesis Prodrugs - pharmacokinetics Prodrugs - pharmacology Rats Solubility Structure-Activity Relationship Survival Thiazoles - chemical synthesis Thiazoles - pharmacokinetics Thiazoles - pharmacology Triazoles - chemical synthesis Triazoles - pharmacokinetics Triazoles - pharmacology
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