[LysB3, GluB29] insulin: a novel insulin analog with enhanced β-cell protective action

Insulin receptor substrate (IRS)-2 has been implicated in the promotion of β-cell survival. Here we tested the hypothesis that the novel analog [LysB3, GluB29] insulin (insulin glulisine, IG) might mediate an enhanced β-cell protective effect due to its unique property of preferential IRS-2 phosphor...

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Veröffentlicht in:	Biochemical and biophysical research communications 2003-10, Vol.310 (3), p.852-859
Hauptverfasser:	Rakatzi, Irini, Seipke, Gerhard, Eckel, Jürgen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Caspase 3 Caspases - metabolism Cell Line, Tumor Cytokines Cytokines - metabolism DNA Fragmentation Dose-Response Relationship, Drug Fatty Acids - metabolism Glutamic Acid - chemistry Humans Immunoblotting INS-1 cells Insulin - analogs & derivatives Insulin - chemistry Insulin - metabolism Insulin - pharmacology Insulin analogs Insulin Receptor Substrate Proteins Intracellular Signaling Peptides and Proteins Islets of Langerhans - metabolism Lysine - chemistry Nucleosomes - metabolism Palmitic acid Palmitic Acid - metabolism Phosphoproteins - chemistry Phosphorylation Precipitin Tests Rats Tyrosine - metabolism
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