Increased Genome Instability in Aging Yeast

Increased Genome Instability in Aging Yeast

In the September 26 issue of Science, McMurray and Gottschling (2003) report that aged yeast cells display high rates of loss of heterozygosity. Furthermore, they show that this reflects an impaired ability to correctly detect and repair DNA double-strand breaks. These results provide insights into...

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Veröffentlicht in:Cell 2003-10, Vol.115 (1), p.1-2
Hauptverfasser: Gravel, Serge, Jackson, Stephen P.
Format: Artikel
Sprache:eng
Schlagworte:
Cellular Senescence - physiology
DNA Damage
DNA Repair
Genome
Genome, Fungal
Loss of Heterozygosity
Saccharomyces cerevisiae - genetics
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Zusammenfassung:In the September 26 issue of Science, McMurray and Gottschling (2003) report that aged yeast cells display high rates of loss of heterozygosity. Furthermore, they show that this reflects an impaired ability to correctly detect and repair DNA double-strand breaks. These results provide insights into how aging can engender genomic instability in eukaryotic cells.
ISSN:0092-8674
1097-4172
DOI:10.1016/S0092-8674(03)00766-9