Neural abnormalities during cognitive generation of affect in Treatment-Resistant depression
Dysfunctions in brain regions known to be involved in affect and mood states are thought to be implicated in depression and may have a role in determining the type and symptoms of this illness. Functional magnetic resonance imaging was used to elucidate neural correlates of cognitive generation of a...
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| Veröffentlicht in: | Biological psychiatry (1969) 2003-10, Vol.54 (8), p.777-791 |
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| creator | Kumari, Veena Mitterschiffthaler, Martina T Teasdale, John D Malhi, Gin S Brown, Richard G Giampietro, Vincent Brammer, Michael J Poon, Lucia Simmons, Andrew Williams, Steven C.R Checkley, Stuart A Sharma, Tonmoy |
| description | Dysfunctions in brain regions known to be involved in affect and mood states are thought to be implicated in depression and may have a role in determining the type and symptoms of this illness.
Functional magnetic resonance imaging was used to elucidate neural correlates of cognitive generation of affect, using a previously published paradigm of evoking affect with picture-caption pairs, in patients with unipolar, treatment-resistant depression.
Compared with control participants, patients showed relatively decreased response in the anterior cingulate (rostral; right) with both negative and positive picture-caption pairs and in the medial frontal gyrus and hippocampus (all left) with positive picture-caption pairs. They demonstrated increased response in the inferior (right) and middle temporal gyri (left) with negative picture-caption pairs, and in the parahippocampal gyrus (right), inferior frontal gyrus (left), subgenual cingulate (right), striatum (right), and brain stem (left) with positive picture-caption pairs.
Reduced medial/middle prefrontal and hippocampal activity may account for positive affect disturbances and temporal lobe hyperactivity for negative affect disturbances in treatment-resistant depression. The results also corroborate previous observations from resting positron emission tomography studies and further elucidate the association between hypoactive rostral cingulate and nonresponsiveness to treatment in depression. |
| doi_str_mv | 10.1016/S0006-3223(02)01785-7 |
| format | Article |
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Functional magnetic resonance imaging was used to elucidate neural correlates of cognitive generation of affect, using a previously published paradigm of evoking affect with picture-caption pairs, in patients with unipolar, treatment-resistant depression.
Compared with control participants, patients showed relatively decreased response in the anterior cingulate (rostral; right) with both negative and positive picture-caption pairs and in the medial frontal gyrus and hippocampus (all left) with positive picture-caption pairs. They demonstrated increased response in the inferior (right) and middle temporal gyri (left) with negative picture-caption pairs, and in the parahippocampal gyrus (right), inferior frontal gyrus (left), subgenual cingulate (right), striatum (right), and brain stem (left) with positive picture-caption pairs.
Reduced medial/middle prefrontal and hippocampal activity may account for positive affect disturbances and temporal lobe hyperactivity for negative affect disturbances in treatment-resistant depression. The results also corroborate previous observations from resting positron emission tomography studies and further elucidate the association between hypoactive rostral cingulate and nonresponsiveness to treatment in depression.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/S0006-3223(02)01785-7</identifier><identifier>PMID: 14550677</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Adult and adolescent clinical studies ; Affect ; affective processing ; Antidepressive Agents - therapeutic use ; Biological and medical sciences ; Brain - anatomy & histology ; Brain - metabolism ; Brain - physiopathology ; Cognition Disorders - diagnosis ; Cognition Disorders - etiology ; Depression ; Depressive Disorder, Major - complications ; Depressive Disorder, Major - drug therapy ; Depressive Disorder, Major - physiopathology ; Drug Resistance ; Female ; functional magnetic resonance imaging ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Imaging ; Medical sciences ; Middle Aged ; Mood disorders ; Nervous system ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><ispartof>Biological psychiatry (1969), 2003-10, Vol.54 (8), p.777-791</ispartof><rights>2003 Society of Biological Psychiatry</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-df5adec85cb461a3332ce37b51ed1ff9f13148c79da13ca88670704494bf92813</citedby><cites>FETCH-LOGICAL-c445t-df5adec85cb461a3332ce37b51ed1ff9f13148c79da13ca88670704494bf92813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006322302017857$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15195614$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14550677$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kumari, Veena</creatorcontrib><creatorcontrib>Mitterschiffthaler, Martina T</creatorcontrib><creatorcontrib>Teasdale, John D</creatorcontrib><creatorcontrib>Malhi, Gin S</creatorcontrib><creatorcontrib>Brown, Richard G</creatorcontrib><creatorcontrib>Giampietro, Vincent</creatorcontrib><creatorcontrib>Brammer, Michael J</creatorcontrib><creatorcontrib>Poon, Lucia</creatorcontrib><creatorcontrib>Simmons, Andrew</creatorcontrib><creatorcontrib>Williams, Steven C.R</creatorcontrib><creatorcontrib>Checkley, Stuart A</creatorcontrib><creatorcontrib>Sharma, Tonmoy</creatorcontrib><title>Neural abnormalities during cognitive generation of affect in Treatment-Resistant depression</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>Dysfunctions in brain regions known to be involved in affect and mood states are thought to be implicated in depression and may have a role in determining the type and symptoms of this illness.
Functional magnetic resonance imaging was used to elucidate neural correlates of cognitive generation of affect, using a previously published paradigm of evoking affect with picture-caption pairs, in patients with unipolar, treatment-resistant depression.
Compared with control participants, patients showed relatively decreased response in the anterior cingulate (rostral; right) with both negative and positive picture-caption pairs and in the medial frontal gyrus and hippocampus (all left) with positive picture-caption pairs. They demonstrated increased response in the inferior (right) and middle temporal gyri (left) with negative picture-caption pairs, and in the parahippocampal gyrus (right), inferior frontal gyrus (left), subgenual cingulate (right), striatum (right), and brain stem (left) with positive picture-caption pairs.
Reduced medial/middle prefrontal and hippocampal activity may account for positive affect disturbances and temporal lobe hyperactivity for negative affect disturbances in treatment-resistant depression. The results also corroborate previous observations from resting positron emission tomography studies and further elucidate the association between hypoactive rostral cingulate and nonresponsiveness to treatment in depression.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Affect</subject><subject>affective processing</subject><subject>Antidepressive Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Brain - anatomy & histology</subject><subject>Brain - metabolism</subject><subject>Brain - physiopathology</subject><subject>Cognition Disorders - diagnosis</subject><subject>Cognition Disorders - etiology</subject><subject>Depression</subject><subject>Depressive Disorder, Major - complications</subject><subject>Depressive Disorder, Major - drug therapy</subject><subject>Depressive Disorder, Major - physiopathology</subject><subject>Drug Resistance</subject><subject>Female</subject><subject>functional magnetic resonance imaging</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mood disorders</subject><subject>Nervous system</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0MuKFDEUgOEgitOOPoKSjaKL0lwrVSuRwRsMCjruhHAqOWkiVak2SQ349mamG2fpKiR8Jwk_IU85e80Z7998Z4z1nRRCvmTiFeNm0J25R3Z8MLITion7ZPePnJFHpfxqWyMEf0jOuNKa9cbsyM8vuGWYKUxpzQvMsUYs1G85pj116z61g2uke0yYocY10TVQCAFdpTHRq4xQF0y1-4YllgqpUo-HjKU0-5g8CDAXfHJaz8mPD--vLj51l18_fr54d9k5pXTtfNDg0Q3aTarnIKUUDqWZNEfPQxgDl1wNzoweuHQwDL1hhik1qimMYuDynLw43nvI6-8NS7VLLA7nGRKuW7FGm54xyRrUR-jyWkrGYA85LpD_WM7sTVZ7m9XeNLNM2Nus1rS5Z6cHtmlBfzd16tjA8xOA4mAOGZKL5c5pPuqeq-beHh22HNcRsy0uYnLoY25JrV_jf77yF6N2lUg</recordid><startdate>20031015</startdate><enddate>20031015</enddate><creator>Kumari, Veena</creator><creator>Mitterschiffthaler, Martina T</creator><creator>Teasdale, John D</creator><creator>Malhi, Gin S</creator><creator>Brown, Richard G</creator><creator>Giampietro, Vincent</creator><creator>Brammer, Michael J</creator><creator>Poon, Lucia</creator><creator>Simmons, Andrew</creator><creator>Williams, Steven C.R</creator><creator>Checkley, Stuart A</creator><creator>Sharma, Tonmoy</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031015</creationdate><title>Neural abnormalities during cognitive generation of affect in Treatment-Resistant depression</title><author>Kumari, Veena ; Mitterschiffthaler, Martina T ; Teasdale, John D ; Malhi, Gin S ; Brown, Richard G ; Giampietro, Vincent ; Brammer, Michael J ; Poon, Lucia ; Simmons, Andrew ; Williams, Steven C.R ; Checkley, Stuart A ; Sharma, Tonmoy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-df5adec85cb461a3332ce37b51ed1ff9f13148c79da13ca88670704494bf92813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Affect</topic><topic>affective processing</topic><topic>Antidepressive Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Brain - anatomy & histology</topic><topic>Brain - metabolism</topic><topic>Brain - physiopathology</topic><topic>Cognition Disorders - diagnosis</topic><topic>Cognition Disorders - etiology</topic><topic>Depression</topic><topic>Depressive Disorder, Major - complications</topic><topic>Depressive Disorder, Major - drug therapy</topic><topic>Depressive Disorder, Major - physiopathology</topic><topic>Drug Resistance</topic><topic>Female</topic><topic>functional magnetic resonance imaging</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mood disorders</topic><topic>Nervous system</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kumari, Veena</creatorcontrib><creatorcontrib>Mitterschiffthaler, Martina T</creatorcontrib><creatorcontrib>Teasdale, John D</creatorcontrib><creatorcontrib>Malhi, Gin S</creatorcontrib><creatorcontrib>Brown, Richard G</creatorcontrib><creatorcontrib>Giampietro, Vincent</creatorcontrib><creatorcontrib>Brammer, Michael J</creatorcontrib><creatorcontrib>Poon, Lucia</creatorcontrib><creatorcontrib>Simmons, Andrew</creatorcontrib><creatorcontrib>Williams, Steven C.R</creatorcontrib><creatorcontrib>Checkley, Stuart A</creatorcontrib><creatorcontrib>Sharma, Tonmoy</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kumari, Veena</au><au>Mitterschiffthaler, Martina T</au><au>Teasdale, John D</au><au>Malhi, Gin S</au><au>Brown, Richard G</au><au>Giampietro, Vincent</au><au>Brammer, Michael J</au><au>Poon, Lucia</au><au>Simmons, Andrew</au><au>Williams, Steven C.R</au><au>Checkley, Stuart A</au><au>Sharma, Tonmoy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neural abnormalities during cognitive generation of affect in Treatment-Resistant depression</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>2003-10-15</date><risdate>2003</risdate><volume>54</volume><issue>8</issue><spage>777</spage><epage>791</epage><pages>777-791</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>Dysfunctions in brain regions known to be involved in affect and mood states are thought to be implicated in depression and may have a role in determining the type and symptoms of this illness.
Functional magnetic resonance imaging was used to elucidate neural correlates of cognitive generation of affect, using a previously published paradigm of evoking affect with picture-caption pairs, in patients with unipolar, treatment-resistant depression.
Compared with control participants, patients showed relatively decreased response in the anterior cingulate (rostral; right) with both negative and positive picture-caption pairs and in the medial frontal gyrus and hippocampus (all left) with positive picture-caption pairs. They demonstrated increased response in the inferior (right) and middle temporal gyri (left) with negative picture-caption pairs, and in the parahippocampal gyrus (right), inferior frontal gyrus (left), subgenual cingulate (right), striatum (right), and brain stem (left) with positive picture-caption pairs.
Reduced medial/middle prefrontal and hippocampal activity may account for positive affect disturbances and temporal lobe hyperactivity for negative affect disturbances in treatment-resistant depression. The results also corroborate previous observations from resting positron emission tomography studies and further elucidate the association between hypoactive rostral cingulate and nonresponsiveness to treatment in depression.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>14550677</pmid><doi>10.1016/S0006-3223(02)01785-7</doi><tpages>15</tpages></addata></record> |
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| ispartof | Biological psychiatry (1969), 2003-10, Vol.54 (8), p.777-791 |
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| subjects | Adult Adult and adolescent clinical studies Affect affective processing Antidepressive Agents - therapeutic use Biological and medical sciences Brain - anatomy & histology Brain - metabolism Brain - physiopathology Cognition Disorders - diagnosis Cognition Disorders - etiology Depression Depressive Disorder, Major - complications Depressive Disorder, Major - drug therapy Depressive Disorder, Major - physiopathology Drug Resistance Female functional magnetic resonance imaging Humans Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging Medical sciences Middle Aged Mood disorders Nervous system Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Radiodiagnosis. Nmr imagery. Nmr spectrometry |
| title | Neural abnormalities during cognitive generation of affect in Treatment-Resistant depression |
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