Thiorphan-induced neprilysin inhibition raises amyloid β levels in rabbit cortex and cerebrospinal fluid

Studies on the pathogenesis of Alzheimer's disease (AD) suggest overproduction of amyloid β (Aβ) may not be the only pathogenic route to AD. Decreased degradation of Aβ is another possible disease mechanism. Neprilysin is a neutral endopeptidase that has been proposed to be the major enzyme res...

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