Thrombin stimulates production of fibronectin by human proximal tubular epithelial cells via a transforming growth factor-β-dependent mechanism

Background. Tubulointerstitial fibrosis contributes to the progression of many forms of glomerular disease and to end-stage renal failure. Inflammatory mediators generated during glomerular injury may induce tubulointerstitial lesions by stimulating tubular cells. Thrombin has multiple biological fu...

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Veröffentlicht in:	Nephrology, dialysis, transplantation dialysis, transplantation, 2003-11, Vol.18 (11), p.2248-2254
Hauptverfasser:	Shirato, Kenichi, Osawa, Hiroshi, Kaizuka, Mitsuaki, Nakamura, Norio, Sugawara, Toshiyuki, Nakamura, Masayuki, Tamura, Michiko, Yamabe, Hideaki, Okumura, Ken
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - biosynthesis Actins - genetics Biological and medical sciences Cell Culture Techniques Epithelial Cells - metabolism fibronectin Fibronectins - biosynthesis Fibronectins - genetics human proximal tubular epithelial cell Humans Interstitial nephritis Kidney Tubules, Proximal - metabolism Medical sciences Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure RNA, Messenger - genetics TGF-β thrombin Thrombin - physiology Transforming Growth Factor beta - metabolism tubulointerstitial fibrosis
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