A model of calcium regulation in smooth muscle cell
A model of smooth muscle cell is proposed to describe the mechanisms by which intracellular calcium (Ca i) is regulated when the cell is stimulated by noradrenaline (NA)/agonist (Ag) or depolarized. The intracellular Ca 2+ store is comprised of two calcium pools: A-store which is sensitive to inosit...
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| Veröffentlicht in: | Cell calcium (Edinburgh) 1993-03, Vol.14 (3), p.227-243 |
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| creator | Wong, A.Y.K. Klassen, G.A. |
| description | A model of smooth muscle cell is proposed to describe the mechanisms by which intracellular calcium (Ca
i) is regulated when the cell is stimulated by noradrenaline (NA)/agonist (Ag) or depolarized. The intracellular Ca
2+ store is comprised of two calcium pools: A-store which is sensitive to inositol 1,4,5 trisphosphate (IP
3) and C-store, insensitive to IP
3 but sensitive to Ca
i. The A-store is refilled by Ca
2+ from C-store and reuptake of Ca
i. The uptake rate is dependent on the degree of filling in the A-store. The C-store, activated by Ca
i, is replenished by extracellular Ca
2+ (Ca
0). IP
3 generated by NA or Ag changes the A-store permeability, discharging its Ca
2+ into the cytosol. Depolarization activates Ca
2+ current through the L-type channels. The following events are simulated and compared with experimental observations: (a) Ca
i transient stimulated by high K
+; (b) Ca
i transient and Ca
2+ efflux induced by shortlasting and longlasting NA in the absence of Ca
0; (c) effect of lanthanum on NA-induced Ca
i and Ca
2+ efflux; and (d) effects of nifedipine, ryanodine, BAY K 8644 and cyclopiazonic acid on Ca
i. |
| doi_str_mv | 10.1016/0143-4160(93)90070-M |
| format | Article |
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i) is regulated when the cell is stimulated by noradrenaline (NA)/agonist (Ag) or depolarized. The intracellular Ca
2+ store is comprised of two calcium pools: A-store which is sensitive to inositol 1,4,5 trisphosphate (IP
3) and C-store, insensitive to IP
3 but sensitive to Ca
i. The A-store is refilled by Ca
2+ from C-store and reuptake of Ca
i. The uptake rate is dependent on the degree of filling in the A-store. The C-store, activated by Ca
i, is replenished by extracellular Ca
2+ (Ca
0). IP
3 generated by NA or Ag changes the A-store permeability, discharging its Ca
2+ into the cytosol. Depolarization activates Ca
2+ current through the L-type channels. The following events are simulated and compared with experimental observations: (a) Ca
i transient stimulated by high K
+; (b) Ca
i transient and Ca
2+ efflux induced by shortlasting and longlasting NA in the absence of Ca
0; (c) effect of lanthanum on NA-induced Ca
i and Ca
2+ efflux; and (d) effects of nifedipine, ryanodine, BAY K 8644 and cyclopiazonic acid on Ca
i.</description><identifier>ISSN: 0143-4160</identifier><identifier>EISSN: 1532-1991</identifier><identifier>DOI: 10.1016/0143-4160(93)90070-M</identifier><identifier>PMID: 8388778</identifier><identifier>CODEN: CECADV</identifier><language>eng</language><publisher>Oxford: Elsevier India Pvt Ltd</publisher><subject>Animals ; Biological and medical sciences ; Calcium - metabolism ; Calcium - pharmacology ; Calcium Channels - metabolism ; Cell physiology ; Cytosol - metabolism ; Fundamental and applied biological sciences. Psychology ; Inositol 1,4,5-Trisphosphate - pharmacology ; Kinetics ; Lanthanum - pharmacology ; Models, Theoretical ; Molecular and cellular biology ; Muscle Contraction ; Muscle, Smooth, Vascular - drug effects ; Muscle, Smooth, Vascular - metabolism ; Norepinephrine - analogs & derivatives ; Norepinephrine - pharmacology ; Responses to growth factors, tumor promotors, other factors ; Ryanodine - pharmacology</subject><ispartof>Cell calcium (Edinburgh), 1993-03, Vol.14 (3), p.227-243</ispartof><rights>1993</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-100408aa5f4cf2815b765461e4b24b477a3cbf91ac926470b15540f15faf05db3</citedby><cites>FETCH-LOGICAL-c417t-100408aa5f4cf2815b765461e4b24b477a3cbf91ac926470b15540f15faf05db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0143-4160(93)90070-M$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4654501$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8388778$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wong, A.Y.K.</creatorcontrib><creatorcontrib>Klassen, G.A.</creatorcontrib><title>A model of calcium regulation in smooth muscle cell</title><title>Cell calcium (Edinburgh)</title><addtitle>Cell Calcium</addtitle><description>A model of smooth muscle cell is proposed to describe the mechanisms by which intracellular calcium (Ca
i) is regulated when the cell is stimulated by noradrenaline (NA)/agonist (Ag) or depolarized. The intracellular Ca
2+ store is comprised of two calcium pools: A-store which is sensitive to inositol 1,4,5 trisphosphate (IP
3) and C-store, insensitive to IP
3 but sensitive to Ca
i. The A-store is refilled by Ca
2+ from C-store and reuptake of Ca
i. The uptake rate is dependent on the degree of filling in the A-store. The C-store, activated by Ca
i, is replenished by extracellular Ca
2+ (Ca
0). IP
3 generated by NA or Ag changes the A-store permeability, discharging its Ca
2+ into the cytosol. Depolarization activates Ca
2+ current through the L-type channels. The following events are simulated and compared with experimental observations: (a) Ca
i transient stimulated by high K
+; (b) Ca
i transient and Ca
2+ efflux induced by shortlasting and longlasting NA in the absence of Ca
0; (c) effect of lanthanum on NA-induced Ca
i and Ca
2+ efflux; and (d) effects of nifedipine, ryanodine, BAY K 8644 and cyclopiazonic acid on Ca
i.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Calcium - metabolism</subject><subject>Calcium - pharmacology</subject><subject>Calcium Channels - metabolism</subject><subject>Cell physiology</subject><subject>Cytosol - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Inositol 1,4,5-Trisphosphate - pharmacology</subject><subject>Kinetics</subject><subject>Lanthanum - pharmacology</subject><subject>Models, Theoretical</subject><subject>Molecular and cellular biology</subject><subject>Muscle Contraction</subject><subject>Muscle, Smooth, Vascular - drug effects</subject><subject>Muscle, Smooth, Vascular - metabolism</subject><subject>Norepinephrine - analogs & derivatives</subject><subject>Norepinephrine - pharmacology</subject><subject>Responses to growth factors, tumor promotors, other factors</subject><subject>Ryanodine - pharmacology</subject><issn>0143-4160</issn><issn>1532-1991</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMouq7-A4UeRPRQndkkTXMRFvELFC96DmmaaKRt1qQV_Pd23WWPeprD-8zwzkPIEcIFAhaXgIzmDAs4k_RcAgjIn7bIBDmd5SglbpPJBtkj-yl9AICkAnfJbknLUohyQug8a0Ntmyy4zOjG-KHNon0bGt370GW-y1IbQv-etUMyjc2MbZoDsuN0k-zhek7J6-3Ny_V9_vh893A9f8wNQ9HnCMCg1Jo7ZtysRF6JgrMCLatmrGJCaGoqJ1EbOSuYgAo5Z-CQO-2A1xWdktPV3UUMn4NNvWp9WhbQnQ1DUoILXsqC_QtiwUugHEaQrUATQ0rROrWIvtXxWyGopVS1NKaWxpSk6leqehrXjtf3h6q19WZpbXHMT9a5TqNEF3VnfNpgbHybA47Y1Qqzo7Qvb6NKxtvO2NpHa3pVB_93jx9DK5Br</recordid><startdate>19930301</startdate><enddate>19930301</enddate><creator>Wong, A.Y.K.</creator><creator>Klassen, G.A.</creator><general>Elsevier India Pvt Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>19930301</creationdate><title>A model of calcium regulation in smooth muscle cell</title><author>Wong, A.Y.K. ; Klassen, G.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-100408aa5f4cf2815b765461e4b24b477a3cbf91ac926470b15540f15faf05db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Calcium - metabolism</topic><topic>Calcium - pharmacology</topic><topic>Calcium Channels - metabolism</topic><topic>Cell physiology</topic><topic>Cytosol - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Inositol 1,4,5-Trisphosphate - pharmacology</topic><topic>Kinetics</topic><topic>Lanthanum - pharmacology</topic><topic>Models, Theoretical</topic><topic>Molecular and cellular biology</topic><topic>Muscle Contraction</topic><topic>Muscle, Smooth, Vascular - drug effects</topic><topic>Muscle, Smooth, Vascular - metabolism</topic><topic>Norepinephrine - analogs & derivatives</topic><topic>Norepinephrine - pharmacology</topic><topic>Responses to growth factors, tumor promotors, other factors</topic><topic>Ryanodine - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wong, A.Y.K.</creatorcontrib><creatorcontrib>Klassen, G.A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cell calcium (Edinburgh)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wong, A.Y.K.</au><au>Klassen, G.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A model of calcium regulation in smooth muscle cell</atitle><jtitle>Cell calcium (Edinburgh)</jtitle><addtitle>Cell Calcium</addtitle><date>1993-03-01</date><risdate>1993</risdate><volume>14</volume><issue>3</issue><spage>227</spage><epage>243</epage><pages>227-243</pages><issn>0143-4160</issn><eissn>1532-1991</eissn><coden>CECADV</coden><abstract>A model of smooth muscle cell is proposed to describe the mechanisms by which intracellular calcium (Ca
i) is regulated when the cell is stimulated by noradrenaline (NA)/agonist (Ag) or depolarized. The intracellular Ca
2+ store is comprised of two calcium pools: A-store which is sensitive to inositol 1,4,5 trisphosphate (IP
3) and C-store, insensitive to IP
3 but sensitive to Ca
i. The A-store is refilled by Ca
2+ from C-store and reuptake of Ca
i. The uptake rate is dependent on the degree of filling in the A-store. The C-store, activated by Ca
i, is replenished by extracellular Ca
2+ (Ca
0). IP
3 generated by NA or Ag changes the A-store permeability, discharging its Ca
2+ into the cytosol. Depolarization activates Ca
2+ current through the L-type channels. The following events are simulated and compared with experimental observations: (a) Ca
i transient stimulated by high K
+; (b) Ca
i transient and Ca
2+ efflux induced by shortlasting and longlasting NA in the absence of Ca
0; (c) effect of lanthanum on NA-induced Ca
i and Ca
2+ efflux; and (d) effects of nifedipine, ryanodine, BAY K 8644 and cyclopiazonic acid on Ca
i.</abstract><cop>Oxford</cop><pub>Elsevier India Pvt Ltd</pub><pmid>8388778</pmid><doi>10.1016/0143-4160(93)90070-M</doi><tpages>17</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0143-4160 |
| ispartof | Cell calcium (Edinburgh), 1993-03, Vol.14 (3), p.227-243 |
| issn | 0143-4160 1532-1991 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75758964 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Biological and medical sciences Calcium - metabolism Calcium - pharmacology Calcium Channels - metabolism Cell physiology Cytosol - metabolism Fundamental and applied biological sciences. Psychology Inositol 1,4,5-Trisphosphate - pharmacology Kinetics Lanthanum - pharmacology Models, Theoretical Molecular and cellular biology Muscle Contraction Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Norepinephrine - analogs & derivatives Norepinephrine - pharmacology Responses to growth factors, tumor promotors, other factors Ryanodine - pharmacology |
| title | A model of calcium regulation in smooth muscle cell |
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