Pathogen Genotyping in Polyclonal Infections: Application of a Fluorogenic Polymerase–Chain-Reaction Assay in Malaria

Pathogen genotyping of polyclonal infections is limited by 2 major drawbacks: (1) how to establish whether multiple mutations detected in 1 gene belong to the same clone and (2) how to evaluate the proportion of different genotypes in a given sample. For drug-resistance genotyping in Plasmodium falc...

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Veröffentlicht in:	The Journal of infectious diseases 2003-10, Vol.188 (8), p.1245-1249
Hauptverfasser:	Decuypere, Saskia, Elinck, Ellen, Overmeir, Chantal Van, Talisuna, Ambrose O., D’Alessandro, Umberto, Dujardin, Jean-Claude
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Codons DNA, Protozoan - analysis Fluorescence Fluorescence Resonance Energy Transfer Fluorescent Dyes Fundamental and applied biological sciences. Psychology Genetic mutation Genotype Genotypes Human protozoal diseases Humans Infections Infectious diseases Malaria Malaria, Falciparum - parasitology Medical sciences Melting Microbiology Parasites Parasitic diseases Pathogens Plasmodium falciparum - classification Plasmodium falciparum - genetics Polymerase chain reaction Polymerase Chain Reaction - methods Protozoal diseases Tetrahydrofolate Dehydrogenase - genetics
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