Modulation of renal glomerular disease using remote delivery of adenoviral-encoded solubletype II TGF-β receptor fusion molecule

Background Systemic adenoviral (Ad) gene therapy for renal disorders is largely hampered by the unique architecture of the kidney. Consequently, currently available Ad vectors are of only limited therapeutic utility in the context of glomerular and fibroproliferative renal diseases. Methods The Ad v...

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Veröffentlicht in:	The journal of gene medicine 2003-10, Vol.5 (10), p.839-851
Hauptverfasser:	Haviv, Yosef S., Takayama, Koichi, Nagi, Peter A., Tousson, Albert, Cook, William, Wang, Minghui, Lam, John T., Naito, Seiji, Lei, Xiaosheng, Carey, Delicia E., Curiel, David T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics adenovirus Animals Disease Models, Animal experimental glomerulonephritis Fibrosis - therapy gene therapy Gene Transfer Techniques Genetic Therapy Genetic Vectors - administration & dosage Glomerulonephritis - genetics Glomerulonephritis - therapy Injections, Intramuscular Kidney - pathology Kidney Diseases - genetics Kidney Diseases - therapy Mice Mice, Inbred BALB C Protein-Serine-Threonine Kinases Receptors, Transforming Growth Factor beta - genetics Recombinant Fusion Proteins - genetics renal fibrosis Transforming Growth Factor beta - metabolism transforming growth factor-β receptor type II unilateral ureter obstruction
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