Coxsackievirus B1–induced chronic inflammatory myopathy: differences in induction of autoantibodies to muscle and nuclear antigens by cloned myopathic and amyopathic viruses

Infection of susceptible strains of mice with the myopathic Tucson strain of coxsackievirus B1 (CVB1 T) leads to the development of chronic inflammatory myopathy (CIM). The underlying mechanism of CIM appears to be immunopathic, but it is not known whether autoimmunity is involved. The objectives of...

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Veröffentlicht in:	The Journal of laboratory and clinical medicine 2003-09, Vol.142 (3), p.196-204
Hauptverfasser:	Tam, Patricia E, Fontana, Donna R, Messner, Ronald P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Viral - blood Antigens, Nuclear - immunology Autoantibodies - blood Biological and medical sciences Chronic Disease Cloning, Molecular Coxsackievirus Infections - immunology Coxsackievirus Infections - pathology Enterovirus B, Human - genetics Enterovirus B, Human - immunology Enterovirus B, Human - pathogenicity Experimental and animal immunopathology. Animal models Immunoglobulin G - blood Immunopathology Medical sciences Mice Mice, Inbred ICR Muscle, Skeletal - immunology Muscle, Skeletal - pathology Specific Pathogen-Free Organisms Virulence
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