High expression of bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy

The BCL-2 proto-oncogene encodes a mitochondrial protein that blocks programmed cell death. High amounts of bcl-2 protein are found not only in lymphoid malignancies, but also in normal tissues characterized by apoptotic cell death, including bone marrow. Using a monoclonal antibody to bcl-2 protein...

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Veröffentlicht in:	Blood 1993-06, Vol.81 (11), p.3091-3096
Hauptverfasser:	CAMPOS, L, ROUAULT, J.-P, SABIDO, O, ORIOL, P, NOURI, N, VASSELON, C, ARCHIMBAUD, E, MAGAUD, J.-P, GUYOTAT, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adult Antigens, CD - analysis Antigens, CD34 Antineoplastic Agents - therapeutic use Biological and medical sciences Blotting, Western Cells, Cultured Female Flow Cytometry Hematologic and hematopoietic diseases Humans In Vitro Techniques Leukemia, Myeloid - drug therapy Leukemia, Myeloid - metabolism Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Middle Aged Multivariate Analysis Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 Survival Analysis Tumor Cells, Cultured
Online-Zugang:	Volltext
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