Genotype and allele frequency of CYP2D6 in Tamilian population
To assess the frequency of CYP2D6 *3, *4, *5 and *10 allelic variants in a South Indian population and compare the frequencies with other major populations. Polymerase chain reaction (PCR) or PCR-restriction fragment length polymorphism (RFLP)-based methods were used to identify the CYP2D6 genotypes...
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| Veröffentlicht in: | European journal of clinical pharmacology 2003-10, Vol.59 (7), p.517-520 |
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| container_title | European journal of clinical pharmacology |
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| creator | Adithan, C Gerard, N Naveen, A T Koumaravelou, K Shashindran, C H Krishnamoorthy, R |
| description | To assess the frequency of CYP2D6 *3, *4, *5 and *10 allelic variants in a South Indian population and compare the frequencies with other major populations.
Polymerase chain reaction (PCR) or PCR-restriction fragment length polymorphism (RFLP)-based methods were used to identify the CYP2D6 genotypes of 106 healthy unrelated male and female volunteers of Tamilian origin. The allele and genotype frequencies observed were compared with other major populations.
The *10 allele was the most frequent mutant allele in Tamilians (20.3%). The *5 allele occurred at 0.9% and the *3 allele was not detected. The most frequent allele causing enzyme inactivation was *4 allele in Tamilians (6.6%), which is significantly higher than that reported in Japanese (0%).
The *10 allele is the most common mutant allele in Tamilians. The CYP2D6*4 and CYP2D6*5 alleles are distributed in a significantly different way in the Tamil population relative to Oriental populations. |
| doi_str_mv | 10.1007/s00228-003-0657-4 |
| format | Article |
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Polymerase chain reaction (PCR) or PCR-restriction fragment length polymorphism (RFLP)-based methods were used to identify the CYP2D6 genotypes of 106 healthy unrelated male and female volunteers of Tamilian origin. The allele and genotype frequencies observed were compared with other major populations.
The *10 allele was the most frequent mutant allele in Tamilians (20.3%). The *5 allele occurred at 0.9% and the *3 allele was not detected. The most frequent allele causing enzyme inactivation was *4 allele in Tamilians (6.6%), which is significantly higher than that reported in Japanese (0%).
The *10 allele is the most common mutant allele in Tamilians. The CYP2D6*4 and CYP2D6*5 alleles are distributed in a significantly different way in the Tamil population relative to Oriental populations.</description><identifier>ISSN: 0031-6970</identifier><identifier>EISSN: 1432-1041</identifier><identifier>DOI: 10.1007/s00228-003-0657-4</identifier><identifier>PMID: 12942225</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Adult ; Asian Continental Ancestry Group - genetics ; Cytochrome P-450 CYP2D6 - genetics ; Female ; Gene Frequency - genetics ; Genetics, Population ; Genotype ; Humans ; India ; Male ; Mutation ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length</subject><ispartof>European journal of clinical pharmacology, 2003-10, Vol.59 (7), p.517-520</ispartof><rights>Copyright Springer-Verlag 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12942225$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adithan, C</creatorcontrib><creatorcontrib>Gerard, N</creatorcontrib><creatorcontrib>Naveen, A T</creatorcontrib><creatorcontrib>Koumaravelou, K</creatorcontrib><creatorcontrib>Shashindran, C H</creatorcontrib><creatorcontrib>Krishnamoorthy, R</creatorcontrib><title>Genotype and allele frequency of CYP2D6 in Tamilian population</title><title>European journal of clinical pharmacology</title><addtitle>Eur J Clin Pharmacol</addtitle><description>To assess the frequency of CYP2D6 *3, *4, *5 and *10 allelic variants in a South Indian population and compare the frequencies with other major populations.
Polymerase chain reaction (PCR) or PCR-restriction fragment length polymorphism (RFLP)-based methods were used to identify the CYP2D6 genotypes of 106 healthy unrelated male and female volunteers of Tamilian origin. The allele and genotype frequencies observed were compared with other major populations.
The *10 allele was the most frequent mutant allele in Tamilians (20.3%). The *5 allele occurred at 0.9% and the *3 allele was not detected. The most frequent allele causing enzyme inactivation was *4 allele in Tamilians (6.6%), which is significantly higher than that reported in Japanese (0%).
The *10 allele is the most common mutant allele in Tamilians. The CYP2D6*4 and CYP2D6*5 alleles are distributed in a significantly different way in the Tamil population relative to Oriental populations.</description><subject>Adult</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Cytochrome P-450 CYP2D6 - genetics</subject><subject>Female</subject><subject>Gene Frequency - genetics</subject><subject>Genetics, Population</subject><subject>Genotype</subject><subject>Humans</subject><subject>India</subject><subject>Male</subject><subject>Mutation</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Restriction Fragment Length</subject><issn>0031-6970</issn><issn>1432-1041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkL1KxEAYRQdRdF19ABsZLOxGv29-k0aQVVdhQYu1sAozyQxkmUxifop9ewOujdUt7uFyuIRcIdwhgLkfADjPGIBgoJVh8ogsUArOECQek8VcINO5gTNyPgw7AFQ5iFNyhjyXnHO1IA9rn9px33lqU0VtjD56Gnr_PflU7mkb6Orrgz9pWie6tU0da5to13ZTtGPdpgtyEmwc_OUhl-Tz5Xm7emWb9_Xb6nHDOtR6ZKiCsEqg9VrkWQ6orVHBBWNCBkI6G9A5IS2vlMzBO2VK6SvJS4fAfXBiSW5_d7u-ndWGsWjqofQx2uTbaSiMMkrL3MzgzT9w1059mt0KjlKaDHU2Q9cHaHKNr4qurxvb74u_W8QP0Yxitw</recordid><startdate>200310</startdate><enddate>200310</enddate><creator>Adithan, C</creator><creator>Gerard, N</creator><creator>Naveen, A T</creator><creator>Koumaravelou, K</creator><creator>Shashindran, C H</creator><creator>Krishnamoorthy, R</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200310</creationdate><title>Genotype and allele frequency of CYP2D6 in Tamilian population</title><author>Adithan, C ; Gerard, N ; Naveen, A T ; Koumaravelou, K ; Shashindran, C H ; Krishnamoorthy, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p166t-15f3a531ae63989016a75fbf77f8034baf1bb34a2d5490eb57c4ed42cb102efb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Cytochrome P-450 CYP2D6 - genetics</topic><topic>Female</topic><topic>Gene Frequency - genetics</topic><topic>Genetics, Population</topic><topic>Genotype</topic><topic>Humans</topic><topic>India</topic><topic>Male</topic><topic>Mutation</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Restriction Fragment Length</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adithan, C</creatorcontrib><creatorcontrib>Gerard, N</creatorcontrib><creatorcontrib>Naveen, A T</creatorcontrib><creatorcontrib>Koumaravelou, K</creatorcontrib><creatorcontrib>Shashindran, C H</creatorcontrib><creatorcontrib>Krishnamoorthy, R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adithan, C</au><au>Gerard, N</au><au>Naveen, A T</au><au>Koumaravelou, K</au><au>Shashindran, C H</au><au>Krishnamoorthy, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genotype and allele frequency of CYP2D6 in Tamilian population</atitle><jtitle>European journal of clinical pharmacology</jtitle><addtitle>Eur J Clin Pharmacol</addtitle><date>2003-10</date><risdate>2003</risdate><volume>59</volume><issue>7</issue><spage>517</spage><epage>520</epage><pages>517-520</pages><issn>0031-6970</issn><eissn>1432-1041</eissn><abstract>To assess the frequency of CYP2D6 *3, *4, *5 and *10 allelic variants in a South Indian population and compare the frequencies with other major populations.
Polymerase chain reaction (PCR) or PCR-restriction fragment length polymorphism (RFLP)-based methods were used to identify the CYP2D6 genotypes of 106 healthy unrelated male and female volunteers of Tamilian origin. The allele and genotype frequencies observed were compared with other major populations.
The *10 allele was the most frequent mutant allele in Tamilians (20.3%). The *5 allele occurred at 0.9% and the *3 allele was not detected. The most frequent allele causing enzyme inactivation was *4 allele in Tamilians (6.6%), which is significantly higher than that reported in Japanese (0%).
The *10 allele is the most common mutant allele in Tamilians. The CYP2D6*4 and CYP2D6*5 alleles are distributed in a significantly different way in the Tamil population relative to Oriental populations.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>12942225</pmid><doi>10.1007/s00228-003-0657-4</doi><tpages>4</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Adult Asian Continental Ancestry Group - genetics Cytochrome P-450 CYP2D6 - genetics Female Gene Frequency - genetics Genetics, Population Genotype Humans India Male Mutation Polymerase Chain Reaction Polymorphism, Restriction Fragment Length |
| title | Genotype and allele frequency of CYP2D6 in Tamilian population |
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