A comparative study of three ovulation induction protocols in polycystic ovarian disease patients in an in vitro fertilization/embryo transfer program
This study compares the results of three ovulation induction protocols in polycystic ovarian disease (PCOD) patients undergoing an in vitro fertilization-embryo transfer (IVF-ET) program. A total of 85 cycles was studied. The patients were treated with clomiphene citrate (CC) plus human menopausal g...
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| Veröffentlicht in: | Journal of assisted reproduction and genetics 1993, Vol.10 (1), p.15-20 |
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| container_title | Journal of assisted reproduction and genetics |
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| creator | TURHAN, N. Ö ARTINI, P. G D'AMBROGIO, G DROGHINI, F BATTAGLIA, C GENAZZANI, A. D VOLPE, A GENAZZANI, A. R |
| description | This study compares the results of three ovulation induction protocols in polycystic ovarian disease (PCOD) patients undergoing an in vitro fertilization-embryo transfer (IVF-ET) program. A total of 85 cycles was studied. The patients were treated with clomiphene citrate (CC) plus human menopausal gonadotropin (hMG) (CC/hMG group), with purified menofollitropin (pFSH) plus hMG (pFSH/hMG group), and with pFSH/hMG plus gonadotropin releasing hormone analogue (GnRH-a) (analogue group). In the analogue group the suppression of luteinizing hormone (LH) with GnRH-a decreased the number of follicles < 12 mm on the day of human chorionic gonadotropin (hCG) administration and the number and percentage of immature oocytes retrieved and increased the percentage of mature oocytes retrieved.
However, fertilization rates of oocytes, cleaved embryo rates, pregnancy rates following replacement, and pregnancy outcomes were not different.
Although the suppression of the hypothalamic-pituitary-ovarian axis with GnRH-a in PCOD patients improved follicular synchrony and oocyte maturity, none of the ovulation induction protocols was superior to the others with respect to pregnancy rates and pregnancy outcomes. |
| doi_str_mv | 10.1007/BF01204435 |
| format | Article |
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However, fertilization rates of oocytes, cleaved embryo rates, pregnancy rates following replacement, and pregnancy outcomes were not different.
Although the suppression of the hypothalamic-pituitary-ovarian axis with GnRH-a in PCOD patients improved follicular synchrony and oocyte maturity, none of the ovulation induction protocols was superior to the others with respect to pregnancy rates and pregnancy outcomes.</description><identifier>ISSN: 1058-0468</identifier><identifier>EISSN: 1573-7330</identifier><identifier>DOI: 10.1007/BF01204435</identifier><identifier>PMID: 8499674</identifier><identifier>CODEN: JARGE4</identifier><language>eng</language><publisher>New York, NY: Kluwer/Plenum</publisher><subject>Adult ; Biological and medical sciences ; Birth control ; Cell Count - drug effects ; Cellular Senescence - drug effects ; Clinical Protocols ; Embryo Transfer ; Female ; Fertilization in Vitro ; Gynecology. Andrology. Obstetrics ; Humans ; Infertility, Female - therapy ; Medical sciences ; Oocytes - cytology ; Oocytes - drug effects ; Ovulation Induction - methods ; Polycystic Ovary Syndrome - complications ; Pregnancy ; Pregnancy Outcome ; Sterility. Assisted procreation</subject><ispartof>Journal of assisted reproduction and genetics, 1993, Vol.10 (1), p.15-20</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c267t-5372e41240d15537e1b9098eb738624201edfe7fa3f2b8d884e410c5278641aa3</citedby><cites>FETCH-LOGICAL-c267t-5372e41240d15537e1b9098eb738624201edfe7fa3f2b8d884e410c5278641aa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27902,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4734964$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8499674$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TURHAN, N. Ö</creatorcontrib><creatorcontrib>ARTINI, P. G</creatorcontrib><creatorcontrib>D'AMBROGIO, G</creatorcontrib><creatorcontrib>DROGHINI, F</creatorcontrib><creatorcontrib>BATTAGLIA, C</creatorcontrib><creatorcontrib>GENAZZANI, A. D</creatorcontrib><creatorcontrib>VOLPE, A</creatorcontrib><creatorcontrib>GENAZZANI, A. R</creatorcontrib><title>A comparative study of three ovulation induction protocols in polycystic ovarian disease patients in an in vitro fertilization/embryo transfer program</title><title>Journal of assisted reproduction and genetics</title><addtitle>J Assist Reprod Genet</addtitle><description>This study compares the results of three ovulation induction protocols in polycystic ovarian disease (PCOD) patients undergoing an in vitro fertilization-embryo transfer (IVF-ET) program. A total of 85 cycles was studied. The patients were treated with clomiphene citrate (CC) plus human menopausal gonadotropin (hMG) (CC/hMG group), with purified menofollitropin (pFSH) plus hMG (pFSH/hMG group), and with pFSH/hMG plus gonadotropin releasing hormone analogue (GnRH-a) (analogue group). In the analogue group the suppression of luteinizing hormone (LH) with GnRH-a decreased the number of follicles < 12 mm on the day of human chorionic gonadotropin (hCG) administration and the number and percentage of immature oocytes retrieved and increased the percentage of mature oocytes retrieved.
However, fertilization rates of oocytes, cleaved embryo rates, pregnancy rates following replacement, and pregnancy outcomes were not different.
Although the suppression of the hypothalamic-pituitary-ovarian axis with GnRH-a in PCOD patients improved follicular synchrony and oocyte maturity, none of the ovulation induction protocols was superior to the others with respect to pregnancy rates and pregnancy outcomes.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Birth control</subject><subject>Cell Count - drug effects</subject><subject>Cellular Senescence - drug effects</subject><subject>Clinical Protocols</subject><subject>Embryo Transfer</subject><subject>Female</subject><subject>Fertilization in Vitro</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Infertility, Female - therapy</subject><subject>Medical sciences</subject><subject>Oocytes - cytology</subject><subject>Oocytes - drug effects</subject><subject>Ovulation Induction - methods</subject><subject>Polycystic Ovary Syndrome - complications</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Sterility. 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R</creator><general>Kluwer/Plenum</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1993</creationdate><title>A comparative study of three ovulation induction protocols in polycystic ovarian disease patients in an in vitro fertilization/embryo transfer program</title><author>TURHAN, N. Ö ; ARTINI, P. G ; D'AMBROGIO, G ; DROGHINI, F ; BATTAGLIA, C ; GENAZZANI, A. D ; VOLPE, A ; GENAZZANI, A. R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c267t-5372e41240d15537e1b9098eb738624201edfe7fa3f2b8d884e410c5278641aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Birth control</topic><topic>Cell Count - drug effects</topic><topic>Cellular Senescence - drug effects</topic><topic>Clinical Protocols</topic><topic>Embryo Transfer</topic><topic>Female</topic><topic>Fertilization in Vitro</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Infertility, Female - therapy</topic><topic>Medical sciences</topic><topic>Oocytes - cytology</topic><topic>Oocytes - drug effects</topic><topic>Ovulation Induction - methods</topic><topic>Polycystic Ovary Syndrome - complications</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Sterility. Assisted procreation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TURHAN, N. Ö</creatorcontrib><creatorcontrib>ARTINI, P. G</creatorcontrib><creatorcontrib>D'AMBROGIO, G</creatorcontrib><creatorcontrib>DROGHINI, F</creatorcontrib><creatorcontrib>BATTAGLIA, C</creatorcontrib><creatorcontrib>GENAZZANI, A. D</creatorcontrib><creatorcontrib>VOLPE, A</creatorcontrib><creatorcontrib>GENAZZANI, A. R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of assisted reproduction and genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TURHAN, N. Ö</au><au>ARTINI, P. G</au><au>D'AMBROGIO, G</au><au>DROGHINI, F</au><au>BATTAGLIA, C</au><au>GENAZZANI, A. D</au><au>VOLPE, A</au><au>GENAZZANI, A. R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A comparative study of three ovulation induction protocols in polycystic ovarian disease patients in an in vitro fertilization/embryo transfer program</atitle><jtitle>Journal of assisted reproduction and genetics</jtitle><addtitle>J Assist Reprod Genet</addtitle><date>1993</date><risdate>1993</risdate><volume>10</volume><issue>1</issue><spage>15</spage><epage>20</epage><pages>15-20</pages><issn>1058-0468</issn><eissn>1573-7330</eissn><coden>JARGE4</coden><abstract>This study compares the results of three ovulation induction protocols in polycystic ovarian disease (PCOD) patients undergoing an in vitro fertilization-embryo transfer (IVF-ET) program. A total of 85 cycles was studied. The patients were treated with clomiphene citrate (CC) plus human menopausal gonadotropin (hMG) (CC/hMG group), with purified menofollitropin (pFSH) plus hMG (pFSH/hMG group), and with pFSH/hMG plus gonadotropin releasing hormone analogue (GnRH-a) (analogue group). In the analogue group the suppression of luteinizing hormone (LH) with GnRH-a decreased the number of follicles < 12 mm on the day of human chorionic gonadotropin (hCG) administration and the number and percentage of immature oocytes retrieved and increased the percentage of mature oocytes retrieved.
However, fertilization rates of oocytes, cleaved embryo rates, pregnancy rates following replacement, and pregnancy outcomes were not different.
Although the suppression of the hypothalamic-pituitary-ovarian axis with GnRH-a in PCOD patients improved follicular synchrony and oocyte maturity, none of the ovulation induction protocols was superior to the others with respect to pregnancy rates and pregnancy outcomes.</abstract><cop>New York, NY</cop><pub>Kluwer/Plenum</pub><pmid>8499674</pmid><doi>10.1007/BF01204435</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of assisted reproduction and genetics, 1993, Vol.10 (1), p.15-20 |
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| subjects | Adult Biological and medical sciences Birth control Cell Count - drug effects Cellular Senescence - drug effects Clinical Protocols Embryo Transfer Female Fertilization in Vitro Gynecology. Andrology. Obstetrics Humans Infertility, Female - therapy Medical sciences Oocytes - cytology Oocytes - drug effects Ovulation Induction - methods Polycystic Ovary Syndrome - complications Pregnancy Pregnancy Outcome Sterility. Assisted procreation |
| title | A comparative study of three ovulation induction protocols in polycystic ovarian disease patients in an in vitro fertilization/embryo transfer program |
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