Detection of a glycosylation-dependent ligand for the T lymphocyte cell adhesion molecule CD2 using a novel multimeric recombinant CD2-binding assay

The CD2 molecule plays an important role in T cell adhesion by interacting with the ligands CD58 (LFA-3) and CD59. In order to detect additional ligands for CD2, potentially of low binding affinity, we have prepared a highly fluorescent, multimeric form of rCD2 whose binding to cells can be quantifi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of immunology (1950) 1993-06, Vol.150 (11), p.4833-4843
Hauptverfasser:	Parish, CR, Recny, MA, Knoppers, MH, Waldron, JC, Warren, HS
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - immunology Antigens, CD - analysis Antigens, CD - physiology Antigens, Differentiation, T-Lymphocyte - analysis Biological and medical sciences CD2 Antigens CD58 Antigens Cell Adhesion Molecules - analysis Cell Line Fundamental and applied biological sciences. Psychology Fundamental immunology Glycosylation Humans Immunobiology Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation Macromolecular Substances Membrane Glycoproteins - analysis Membrane Glycoproteins - physiology Polymers - pharmacology Radioligand Assay Receptors, Immunologic - analysis Recombinant Proteins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!