Dexamethasone-induced suppression of aortic atherosclerosis in cholesterol-fed rabbits : possible mechanisms
We investigated the mechanisms by which corticosteroids affect atherosclerosis. Male New Zealand White rabbits were injected with 0.125 mg dexamethasone (n = 10) or vehicle (control group, n = 10). Both groups were fed a 1% cholesterol diet for 8 weeks. Although the dexamethasone-treated animals exh...
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| Veröffentlicht in: | Arteriosclerosis and thrombosis 1993-06, Vol.13 (6), p.892-899 |
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| container_title | Arteriosclerosis and thrombosis |
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| creator | ASAI, K FUNAKI, C HAYASHI, T YAMADA, K NAITO, M KUSUYA, M YOSHIDA, F YOSHIMINE, N KUZUYA, F |
| description | We investigated the mechanisms by which corticosteroids affect atherosclerosis. Male New Zealand White rabbits were injected with 0.125 mg dexamethasone (n = 10) or vehicle (control group, n = 10). Both groups were fed a 1% cholesterol diet for 8 weeks. Although the dexamethasone-treated animals exhibited a greater degree of hyperlipidemia, they exhibited significantly less atherosclerotic plaque of the aortic surface than control animals (7.8% versus 47.2%). Immunofluorescence study of the aortic plaque specimens showed that dexamethasone administration reduced both macrophages and T lymphocytes. In vitro, dexamethasone suppressed the proliferation and differentiation of U937 cells and inhibited uptake and degradation of beta-very low density lipoproteins by mouse peritoneal macrophages. These findings suggest that dexamethasone suppresses the development of atherosclerosis in the aorta of rabbits by inhibiting recruitment and proliferation of macrophages and the formation of foam cells in plaques. |
| doi_str_mv | 10.1161/01.atv.13.6.892 |
| format | Article |
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Male New Zealand White rabbits were injected with 0.125 mg dexamethasone (n = 10) or vehicle (control group, n = 10). Both groups were fed a 1% cholesterol diet for 8 weeks. Although the dexamethasone-treated animals exhibited a greater degree of hyperlipidemia, they exhibited significantly less atherosclerotic plaque of the aortic surface than control animals (7.8% versus 47.2%). Immunofluorescence study of the aortic plaque specimens showed that dexamethasone administration reduced both macrophages and T lymphocytes. In vitro, dexamethasone suppressed the proliferation and differentiation of U937 cells and inhibited uptake and degradation of beta-very low density lipoproteins by mouse peritoneal macrophages. These findings suggest that dexamethasone suppresses the development of atherosclerosis in the aorta of rabbits by inhibiting recruitment and proliferation of macrophages and the formation of foam cells in plaques.</description><identifier>ISSN: 1049-8834</identifier><identifier>EISSN: 2330-9199</identifier><identifier>DOI: 10.1161/01.atv.13.6.892</identifier><identifier>PMID: 8499410</identifier><language>eng</language><publisher>Dallas, TX: American Heart Association</publisher><subject>Animals ; Aorta - drug effects ; Arteriosclerosis - immunology ; Arteriosclerosis - prevention & control ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Body Weight ; Cardiology. Vascular system ; Cell Differentiation - drug effects ; Cell Transformation, Neoplastic - drug effects ; Cholesterol, Dietary - administration & dosage ; Dexamethasone - pharmacology ; Fluorescent Antibody Technique ; Leukemia, Promyelocytic, Acute ; Lipoproteins - blood ; Lipoproteins - drug effects ; Lipoproteins, VLDL - blood ; Lipoproteins, VLDL - metabolism ; Macrophages - cytology ; Macrophages - metabolism ; Male ; Medical sciences ; Mice ; Organ Size ; Peritoneal Cavity - cytology ; Rabbits ; T-Lymphocytes - cytology ; Tumor Cells, Cultured - cytology</subject><ispartof>Arteriosclerosis and thrombosis, 1993-06, Vol.13 (6), p.892-899</ispartof><rights>1994 INIST-CNRS</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-61ec8346eb85d73dbf69ad61c96c5bd4d40b9b302cde990745f7e44865d50d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3962497$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8499410$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ASAI, K</creatorcontrib><creatorcontrib>FUNAKI, C</creatorcontrib><creatorcontrib>HAYASHI, T</creatorcontrib><creatorcontrib>YAMADA, K</creatorcontrib><creatorcontrib>NAITO, M</creatorcontrib><creatorcontrib>KUSUYA, M</creatorcontrib><creatorcontrib>YOSHIDA, F</creatorcontrib><creatorcontrib>YOSHIMINE, N</creatorcontrib><creatorcontrib>KUZUYA, F</creatorcontrib><title>Dexamethasone-induced suppression of aortic atherosclerosis in cholesterol-fed rabbits : possible mechanisms</title><title>Arteriosclerosis and thrombosis</title><addtitle>Arterioscler Thromb</addtitle><description>We investigated the mechanisms by which corticosteroids affect atherosclerosis. Male New Zealand White rabbits were injected with 0.125 mg dexamethasone (n = 10) or vehicle (control group, n = 10). Both groups were fed a 1% cholesterol diet for 8 weeks. Although the dexamethasone-treated animals exhibited a greater degree of hyperlipidemia, they exhibited significantly less atherosclerotic plaque of the aortic surface than control animals (7.8% versus 47.2%). Immunofluorescence study of the aortic plaque specimens showed that dexamethasone administration reduced both macrophages and T lymphocytes. In vitro, dexamethasone suppressed the proliferation and differentiation of U937 cells and inhibited uptake and degradation of beta-very low density lipoproteins by mouse peritoneal macrophages. These findings suggest that dexamethasone suppresses the development of atherosclerosis in the aorta of rabbits by inhibiting recruitment and proliferation of macrophages and the formation of foam cells in plaques.</description><subject>Animals</subject><subject>Aorta - drug effects</subject><subject>Arteriosclerosis - immunology</subject><subject>Arteriosclerosis - prevention & control</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Body Weight</subject><subject>Cardiology. Vascular system</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell Transformation, Neoplastic - drug effects</subject><subject>Cholesterol, Dietary - administration & dosage</subject><subject>Dexamethasone - pharmacology</subject><subject>Fluorescent Antibody Technique</subject><subject>Leukemia, Promyelocytic, Acute</subject><subject>Lipoproteins - blood</subject><subject>Lipoproteins - drug effects</subject><subject>Lipoproteins, VLDL - blood</subject><subject>Lipoproteins, VLDL - metabolism</subject><subject>Macrophages - cytology</subject><subject>Macrophages - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Organ Size</subject><subject>Peritoneal Cavity - cytology</subject><subject>Rabbits</subject><subject>T-Lymphocytes - cytology</subject><subject>Tumor Cells, Cultured - cytology</subject><issn>1049-8834</issn><issn>2330-9199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UMtq3TAQFaEhvU2z7qqgRenOjmTJstVdSJ8Q6KKhW6HHmKsiW67GDunfVyGXbGZgzoMzh5B3nLWcK37NeGu3h5aLVrWj7s7IoROCNZpr_YocOJO6GUchX5M3iH8Yk6Ib9AW5GKXWkrMDSZ_h0c6wHS3mBZq4hN1DoLivawHEmBeaJ2pz2aKndjtCyejT04xI40L9MSfArR5SM1Vhsc7FDeknuuYqdwnoDP5ol4gzviXnk00IV6d9SX59_XJ_-725-_ntx-3NXeMlH7dGcfA1swI39mEQwU1K26C418r3LsggmdNOsM4H0JoNsp8GkHJUfehZEJfk47PrWvLfvYYzc0QPKdkF8o5m6IdeyG6oxOtnoq_vYIHJrCXOtvwznJmndg3j5ub-t-HCKFPbrYr3J-vdzRBe-Kc6K_7hhFv0Nk3FLj7iC01o1Uk9iP-yP4VI</recordid><startdate>19930601</startdate><enddate>19930601</enddate><creator>ASAI, K</creator><creator>FUNAKI, C</creator><creator>HAYASHI, T</creator><creator>YAMADA, K</creator><creator>NAITO, M</creator><creator>KUSUYA, M</creator><creator>YOSHIDA, F</creator><creator>YOSHIMINE, N</creator><creator>KUZUYA, F</creator><general>American Heart Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930601</creationdate><title>Dexamethasone-induced suppression of aortic atherosclerosis in cholesterol-fed rabbits : possible mechanisms</title><author>ASAI, K ; FUNAKI, C ; HAYASHI, T ; YAMADA, K ; NAITO, M ; KUSUYA, M ; YOSHIDA, F ; YOSHIMINE, N ; KUZUYA, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-61ec8346eb85d73dbf69ad61c96c5bd4d40b9b302cde990745f7e44865d50d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Aorta - drug effects</topic><topic>Arteriosclerosis - immunology</topic><topic>Arteriosclerosis - prevention & control</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Body Weight</topic><topic>Cardiology. Vascular system</topic><topic>Cell Differentiation - drug effects</topic><topic>Cell Transformation, Neoplastic - drug effects</topic><topic>Cholesterol, Dietary - administration & dosage</topic><topic>Dexamethasone - pharmacology</topic><topic>Fluorescent Antibody Technique</topic><topic>Leukemia, Promyelocytic, Acute</topic><topic>Lipoproteins - blood</topic><topic>Lipoproteins - drug effects</topic><topic>Lipoproteins, VLDL - blood</topic><topic>Lipoproteins, VLDL - metabolism</topic><topic>Macrophages - cytology</topic><topic>Macrophages - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Organ Size</topic><topic>Peritoneal Cavity - cytology</topic><topic>Rabbits</topic><topic>T-Lymphocytes - cytology</topic><topic>Tumor Cells, Cultured - cytology</topic><toplevel>online_resources</toplevel><creatorcontrib>ASAI, K</creatorcontrib><creatorcontrib>FUNAKI, C</creatorcontrib><creatorcontrib>HAYASHI, T</creatorcontrib><creatorcontrib>YAMADA, K</creatorcontrib><creatorcontrib>NAITO, M</creatorcontrib><creatorcontrib>KUSUYA, M</creatorcontrib><creatorcontrib>YOSHIDA, F</creatorcontrib><creatorcontrib>YOSHIMINE, N</creatorcontrib><creatorcontrib>KUZUYA, F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Arteriosclerosis and thrombosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ASAI, K</au><au>FUNAKI, C</au><au>HAYASHI, T</au><au>YAMADA, K</au><au>NAITO, M</au><au>KUSUYA, M</au><au>YOSHIDA, F</au><au>YOSHIMINE, N</au><au>KUZUYA, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dexamethasone-induced suppression of aortic atherosclerosis in cholesterol-fed rabbits : possible mechanisms</atitle><jtitle>Arteriosclerosis and thrombosis</jtitle><addtitle>Arterioscler Thromb</addtitle><date>1993-06-01</date><risdate>1993</risdate><volume>13</volume><issue>6</issue><spage>892</spage><epage>899</epage><pages>892-899</pages><issn>1049-8834</issn><eissn>2330-9199</eissn><abstract>We investigated the mechanisms by which corticosteroids affect atherosclerosis. Male New Zealand White rabbits were injected with 0.125 mg dexamethasone (n = 10) or vehicle (control group, n = 10). Both groups were fed a 1% cholesterol diet for 8 weeks. Although the dexamethasone-treated animals exhibited a greater degree of hyperlipidemia, they exhibited significantly less atherosclerotic plaque of the aortic surface than control animals (7.8% versus 47.2%). Immunofluorescence study of the aortic plaque specimens showed that dexamethasone administration reduced both macrophages and T lymphocytes. In vitro, dexamethasone suppressed the proliferation and differentiation of U937 cells and inhibited uptake and degradation of beta-very low density lipoproteins by mouse peritoneal macrophages. 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| source | MEDLINE; Journals@Ovid Complete; Alma/SFX Local Collection |
| subjects | Animals Aorta - drug effects Arteriosclerosis - immunology Arteriosclerosis - prevention & control Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Body Weight Cardiology. Vascular system Cell Differentiation - drug effects Cell Transformation, Neoplastic - drug effects Cholesterol, Dietary - administration & dosage Dexamethasone - pharmacology Fluorescent Antibody Technique Leukemia, Promyelocytic, Acute Lipoproteins - blood Lipoproteins - drug effects Lipoproteins, VLDL - blood Lipoproteins, VLDL - metabolism Macrophages - cytology Macrophages - metabolism Male Medical sciences Mice Organ Size Peritoneal Cavity - cytology Rabbits T-Lymphocytes - cytology Tumor Cells, Cultured - cytology |
| title | Dexamethasone-induced suppression of aortic atherosclerosis in cholesterol-fed rabbits : possible mechanisms |
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