Inhibition of Dog and Human Gastric Lipases by Enantiomeric Phosphonate Inhibitors:  A Structure−Activity Study

The crystal structures of gastric lipases in the apo form [Roussel, A., et al. (1999) J. Biol. Chem. 274, 16995−17002] or in complex with the (R P)-undecyl butyl phosphonate [C11Y4(+)] [Roussel, A., et al. (2002) J. Biol. Chem. 277, 2266−2274] have improved our understanding of the structure−activit...

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