Prevalence and spectrum of p53 mutations in white Hispanic and non-Hispanic women with breast cancer
Hispanic women differ from non-Hispanics in breast cancer incidence, stage at diagnosis, and survival. Ethnic differences in genetic makeup, reproductive patterns, diet, socioeconomic status, physical activity, and other unidentified cultural factors may be responsible for the disparity. This study...
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Veröffentlicht in: | Breast cancer research and treatment 2003-09, Vol.81 (1), p.53-60 |
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description | Hispanic women differ from non-Hispanics in breast cancer incidence, stage at diagnosis, and survival. Ethnic differences in genetic makeup, reproductive patterns, diet, socioeconomic status, physical activity, and other unidentified cultural factors may be responsible for the disparity. This study investigated occurrences of p53 tumor suppressor gene mutations in South Florida white Hispanic and white non-Hispanic women with primary breast cancer. Tumor tissues were obtained from a consecutive series of women with breast cancer who underwent breast resection at the Jackson Memorial Hospital, Miami, Florida between 1984 and 1986. A total of 231 women with primary breast cancer, aged 31-85 years, were included in the study. Among them, 64 (27.7%) were white Hispanic and 167 (72.3%) were white non-Hispanic. The majority of the patients were white non-Hispanics (72.3%). Compared to white non-Hispanics, however, white Hispanics had significantly higher proportions of tumors larger than 2 cm (53.1% v.s. 28.7%, p = 0.00) as well as larger tumor size at diagnosis (mean: 4.2 v.s. 3.0 cm, p = 0.00). The p53 gene mutation rate was significantly lower in white Hispanics than in white non-Hispanics (51.6% v.s. 70.7%, p = 0.01). Furthermore, among node-negative breast cancer patients, after adjustment for tumor size at diagnosis, logistic regression results showed that white Hispanics were 71% less likely than white non-Hispanics to carry p53 mutations (OR = 0.29 and 95% CI = 0.09-0.91). We conclude that white Hispanic women with breast cancer might have lower p53 gene mutation prevalence than white non-Hispanic women. |
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Ethnic differences in genetic makeup, reproductive patterns, diet, socioeconomic status, physical activity, and other unidentified cultural factors may be responsible for the disparity. This study investigated occurrences of p53 tumor suppressor gene mutations in South Florida white Hispanic and white non-Hispanic women with primary breast cancer. Tumor tissues were obtained from a consecutive series of women with breast cancer who underwent breast resection at the Jackson Memorial Hospital, Miami, Florida between 1984 and 1986. A total of 231 women with primary breast cancer, aged 31-85 years, were included in the study. Among them, 64 (27.7%) were white Hispanic and 167 (72.3%) were white non-Hispanic. The majority of the patients were white non-Hispanics (72.3%). Compared to white non-Hispanics, however, white Hispanics had significantly higher proportions of tumors larger than 2 cm (53.1% v.s. 28.7%, p = 0.00) as well as larger tumor size at diagnosis (mean: 4.2 v.s. 3.0 cm, p = 0.00). The p53 gene mutation rate was significantly lower in white Hispanics than in white non-Hispanics (51.6% v.s. 70.7%, p = 0.01). Furthermore, among node-negative breast cancer patients, after adjustment for tumor size at diagnosis, logistic regression results showed that white Hispanics were 71% less likely than white non-Hispanics to carry p53 mutations (OR = 0.29 and 95% CI = 0.09-0.91). We conclude that white Hispanic women with breast cancer might have lower p53 gene mutation prevalence than white non-Hispanic women.</description><identifier>ISSN: 0167-6806</identifier><identifier>EISSN: 1573-7217</identifier><identifier>DOI: 10.1023/A:1025422905655</identifier><identifier>PMID: 14531497</identifier><identifier>CODEN: BCTRD6</identifier><language>eng</language><publisher>Dordrecht: Springer</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Breast cancer ; Breast Neoplasms - ethnology ; Cancer research ; Cancer therapies ; European Continental Ancestry Group - genetics ; European Continental Ancestry Group - statistics & numerical data ; Female ; Florida - epidemiology ; Genes ; Genes, p53 ; Gynecology. Andrology. Obstetrics ; Hispanic Americans - genetics ; Hispanic Americans - statistics & numerical data ; Hispanic people ; Humans ; Mammary gland diseases ; Medical sciences ; Middle Aged ; Mutation ; Prevalence ; Tumors ; United States</subject><ispartof>Breast cancer research and treatment, 2003-09, Vol.81 (1), p.53-60</ispartof><rights>2003 INIST-CNRS</rights><rights>Copyright Kluwer Academic Publishers Sep 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c350t-5ddc06e3a04da6bd0b39558c5103d12685e9adc49b70cad751039f46e23c0df23</citedby><cites>FETCH-LOGICAL-c350t-5ddc06e3a04da6bd0b39558c5103d12685e9adc49b70cad751039f46e23c0df23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15089289$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14531497$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HONG LAI</creatorcontrib><creatorcontrib>SHENGHAN LAI</creatorcontrib><creatorcontrib>FANGCHAO MA</creatorcontrib><creatorcontrib>LOU MENG</creatorcontrib><creatorcontrib>TRAPIDO, Edward</creatorcontrib><title>Prevalence and spectrum of p53 mutations in white Hispanic and non-Hispanic women with breast cancer</title><title>Breast cancer research and treatment</title><addtitle>Breast Cancer Res Treat</addtitle><description>Hispanic women differ from non-Hispanics in breast cancer incidence, stage at diagnosis, and survival. Ethnic differences in genetic makeup, reproductive patterns, diet, socioeconomic status, physical activity, and other unidentified cultural factors may be responsible for the disparity. This study investigated occurrences of p53 tumor suppressor gene mutations in South Florida white Hispanic and white non-Hispanic women with primary breast cancer. Tumor tissues were obtained from a consecutive series of women with breast cancer who underwent breast resection at the Jackson Memorial Hospital, Miami, Florida between 1984 and 1986. A total of 231 women with primary breast cancer, aged 31-85 years, were included in the study. Among them, 64 (27.7%) were white Hispanic and 167 (72.3%) were white non-Hispanic. The majority of the patients were white non-Hispanics (72.3%). Compared to white non-Hispanics, however, white Hispanics had significantly higher proportions of tumors larger than 2 cm (53.1% v.s. 28.7%, p = 0.00) as well as larger tumor size at diagnosis (mean: 4.2 v.s. 3.0 cm, p = 0.00). The p53 gene mutation rate was significantly lower in white Hispanics than in white non-Hispanics (51.6% v.s. 70.7%, p = 0.01). Furthermore, among node-negative breast cancer patients, after adjustment for tumor size at diagnosis, logistic regression results showed that white Hispanics were 71% less likely than white non-Hispanics to carry p53 mutations (OR = 0.29 and 95% CI = 0.09-0.91). We conclude that white Hispanic women with breast cancer might have lower p53 gene mutation prevalence than white non-Hispanic women.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - ethnology</subject><subject>Cancer research</subject><subject>Cancer therapies</subject><subject>European Continental Ancestry Group - genetics</subject><subject>European Continental Ancestry Group - statistics & numerical data</subject><subject>Female</subject><subject>Florida - epidemiology</subject><subject>Genes</subject><subject>Genes, p53</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Hispanic Americans - genetics</subject><subject>Hispanic Americans - statistics & numerical data</subject><subject>Hispanic people</subject><subject>Humans</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Prevalence</subject><subject>Tumors</subject><subject>United States</subject><issn>0167-6806</issn><issn>1573-7217</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpd0EtLxTAQBeAgil4fa3cSBN1VJ0mTNO4u4gsEXei6pEmKkTatSav47416UXQ1MHxzGA5C-wROCFB2ujzLg5eUKuCC8zW0IFyyQlIi19ECiJCFqEBsoe2UngFASVCbaIuUnJFSyQWy99G96s4F47AOFqfRmSnOPR5aPHKG-3nSkx9Cwj7gtyc_OXzt06iDN18-DKH4WbwNvcvKT0-4iU6nCRudg-Mu2mh1l9zeau6gx8uLh_Pr4vbu6uZ8eVsYxmEquLUGhGMaSqtFY6FhivPKcALMEioq7pS2plSNBKOt_NyrthSOMgO2pWwHHX_njnF4mV2a6t4n47pOBzfMqZZccqoEyfDwH3we5hjybzUltBRSlVVGp9_IxCGl6Np6jL7X8b0mUH-2Xy_rP-3ni4NV7Nz0zv76Vd0ZHK2ATkZ3bcz1-PTrOFSKVop9AC5ri6U</recordid><startdate>20030901</startdate><enddate>20030901</enddate><creator>HONG LAI</creator><creator>SHENGHAN LAI</creator><creator>FANGCHAO MA</creator><creator>LOU MENG</creator><creator>TRAPIDO, Edward</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20030901</creationdate><title>Prevalence and spectrum of p53 mutations in white Hispanic and non-Hispanic women with breast cancer</title><author>HONG LAI ; SHENGHAN LAI ; FANGCHAO MA ; LOU MENG ; TRAPIDO, Edward</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c350t-5ddc06e3a04da6bd0b39558c5103d12685e9adc49b70cad751039f46e23c0df23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - ethnology</topic><topic>Cancer research</topic><topic>Cancer therapies</topic><topic>European Continental Ancestry Group - genetics</topic><topic>European Continental Ancestry Group - statistics & numerical data</topic><topic>Female</topic><topic>Florida - epidemiology</topic><topic>Genes</topic><topic>Genes, p53</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Hispanic Americans - genetics</topic><topic>Hispanic Americans - statistics & numerical data</topic><topic>Hispanic people</topic><topic>Humans</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>Prevalence</topic><topic>Tumors</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HONG LAI</creatorcontrib><creatorcontrib>SHENGHAN LAI</creatorcontrib><creatorcontrib>FANGCHAO MA</creatorcontrib><creatorcontrib>LOU MENG</creatorcontrib><creatorcontrib>TRAPIDO, Edward</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Breast cancer research and treatment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HONG LAI</au><au>SHENGHAN LAI</au><au>FANGCHAO MA</au><au>LOU MENG</au><au>TRAPIDO, Edward</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and spectrum of p53 mutations in white Hispanic and non-Hispanic women with breast cancer</atitle><jtitle>Breast cancer research and treatment</jtitle><addtitle>Breast Cancer Res Treat</addtitle><date>2003-09-01</date><risdate>2003</risdate><volume>81</volume><issue>1</issue><spage>53</spage><epage>60</epage><pages>53-60</pages><issn>0167-6806</issn><eissn>1573-7217</eissn><coden>BCTRD6</coden><abstract>Hispanic women differ from non-Hispanics in breast cancer incidence, stage at diagnosis, and survival. Ethnic differences in genetic makeup, reproductive patterns, diet, socioeconomic status, physical activity, and other unidentified cultural factors may be responsible for the disparity. This study investigated occurrences of p53 tumor suppressor gene mutations in South Florida white Hispanic and white non-Hispanic women with primary breast cancer. Tumor tissues were obtained from a consecutive series of women with breast cancer who underwent breast resection at the Jackson Memorial Hospital, Miami, Florida between 1984 and 1986. A total of 231 women with primary breast cancer, aged 31-85 years, were included in the study. Among them, 64 (27.7%) were white Hispanic and 167 (72.3%) were white non-Hispanic. The majority of the patients were white non-Hispanics (72.3%). Compared to white non-Hispanics, however, white Hispanics had significantly higher proportions of tumors larger than 2 cm (53.1% v.s. 28.7%, p = 0.00) as well as larger tumor size at diagnosis (mean: 4.2 v.s. 3.0 cm, p = 0.00). The p53 gene mutation rate was significantly lower in white Hispanics than in white non-Hispanics (51.6% v.s. 70.7%, p = 0.01). Furthermore, among node-negative breast cancer patients, after adjustment for tumor size at diagnosis, logistic regression results showed that white Hispanics were 71% less likely than white non-Hispanics to carry p53 mutations (OR = 0.29 and 95% CI = 0.09-0.91). We conclude that white Hispanic women with breast cancer might have lower p53 gene mutation prevalence than white non-Hispanic women.</abstract><cop>Dordrecht</cop><pub>Springer</pub><pmid>14531497</pmid><doi>10.1023/A:1025422905655</doi><tpages>8</tpages></addata></record> |
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subjects | Adult Aged Aged, 80 and over Biological and medical sciences Breast cancer Breast Neoplasms - ethnology Cancer research Cancer therapies European Continental Ancestry Group - genetics European Continental Ancestry Group - statistics & numerical data Female Florida - epidemiology Genes Genes, p53 Gynecology. Andrology. Obstetrics Hispanic Americans - genetics Hispanic Americans - statistics & numerical data Hispanic people Humans Mammary gland diseases Medical sciences Middle Aged Mutation Prevalence Tumors United States |
title | Prevalence and spectrum of p53 mutations in white Hispanic and non-Hispanic women with breast cancer |
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