Antigen processing and presentation of human rhinovirus to CD4 T cells is facilitated by binding to cellular receptors for virus
Human rhinovirus serotypes (HRV) fall into two distinct groups, major and minor, by virtue of their cell receptor‐binding ability. In this study minor receptor‐binding group viruses are demonstrated to bind directly to cells of the murine immune system, including lymphoid dendritic cells which act a...
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| Veröffentlicht in: | European journal of immunology 1993-06, Vol.23 (6), p.1340-1345 |
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| container_end_page | 1345 |
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| container_title | European journal of immunology |
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| creator | Hastings, Gillian Z. Francis, Michael J. Rowlands, D. J. Chain, Benjamin M. |
| description | Human rhinovirus serotypes (HRV) fall into two distinct groups, major and minor, by virtue of their cell receptor‐binding ability. In this study minor receptor‐binding group viruses are demonstrated to bind directly to cells of the murine immune system, including lymphoid dendritic cells which act as antigen‐presenting cells, although they do not produce a productive infection in murine cells. This binding is specific and can be blocked by other serotypes of minor‐group HRV Pre‐treatment of HRV 1A, a minor‐group virus, with HRV 1A‐specific antibodies inhibited the cellular proliferation of murine virus primed T helper cells, whereas antibody treatment of HRV 15, a non‐binding major serotype, gave no inhibition. The cell binding ability of minor‐group HRV played a role in the overall immunogenicity of this virus group, which was shown to be enhanced compared to the immunogenicity of major‐group viruses in mice. |
| doi_str_mv | 10.1002/eji.1830230623 |
| format | Article |
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The cell binding ability of minor‐group HRV played a role in the overall immunogenicity of this virus group, which was shown to be enhanced compared to the immunogenicity of major‐group viruses in mice.</description><identifier>ISSN: 0014-2980</identifier><identifier>EISSN: 1521-4141</identifier><identifier>DOI: 10.1002/eji.1830230623</identifier><identifier>PMID: 8099015</identifier><identifier>CODEN: EJIMAF</identifier><language>eng</language><publisher>Weinheim: WILEY‐VCH Verlag GmbH</publisher><subject>Adjuvants, Immunologic ; Animals ; Antigen processing ; Antigen-Presenting Cells - immunology ; Biological and medical sciences ; CD4 antigen presentation ; CD4-Positive T-Lymphocytes - immunology ; Cells, Cultured ; Fundamental and applied biological sciences. 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J.</creatorcontrib><creatorcontrib>Chain, Benjamin M.</creatorcontrib><title>Antigen processing and presentation of human rhinovirus to CD4 T cells is facilitated by binding to cellular receptors for virus</title><title>European journal of immunology</title><addtitle>Eur J Immunol</addtitle><description>Human rhinovirus serotypes (HRV) fall into two distinct groups, major and minor, by virtue of their cell receptor‐binding ability. In this study minor receptor‐binding group viruses are demonstrated to bind directly to cells of the murine immune system, including lymphoid dendritic cells which act as antigen‐presenting cells, although they do not produce a productive infection in murine cells. This binding is specific and can be blocked by other serotypes of minor‐group HRV Pre‐treatment of HRV 1A, a minor‐group virus, with HRV 1A‐specific antibodies inhibited the cellular proliferation of murine virus primed T helper cells, whereas antibody treatment of HRV 15, a non‐binding major serotype, gave no inhibition. The cell binding ability of minor‐group HRV played a role in the overall immunogenicity of this virus group, which was shown to be enhanced compared to the immunogenicity of major‐group viruses in mice.</description><subject>Adjuvants, Immunologic</subject><subject>Animals</subject><subject>Antigen processing</subject><subject>Antigen-Presenting Cells - immunology</subject><subject>Biological and medical sciences</subject><subject>CD4 antigen presentation</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>Cells, Cultured</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>HeLa Cells</subject><subject>Human rhinovirus</subject><subject>Humans</subject><subject>Immunobiology</subject><subject>In Vitro Techniques</subject><subject>Lymphocyte Activation</subject><subject>Mice</subject><subject>Modulation of the immune response (stimulation, suppression)</subject><subject>Neutralization Tests</subject><subject>Receptors, Virus - metabolism</subject><subject>rhinovirus</subject><subject>Rhinovirus - immunology</subject><subject>Rhinovirus - metabolism</subject><issn>0014-2980</issn><issn>1521-4141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkb1vFDEQxS0ECkegpUNygej2GH_uuoyOAEGRaEK98tqziaM9-7B3g67jT8fHnQJdqtFofu_NjB4hbxmsGQD_iPdhzToBXIDm4hlZMcVZI5lkz8kKgMmGmw5eklel3AOA0cqckbMOjAGmVuT3RZzDLUa6y8lhKSHeUht9bbFgnO0cUqRppHfL1kaa70JMDyEvhc6Jbj5JekMdTlOhodDRujCFKkFPhz0dQvQHtwoekGWymWZ0uJtTrnDK9K_Ra_JitFPBN6d6Tn58vrzZfG2uv3-52lxcN04CiIa5TqJBIVsuuNCDB-s7rYRnwmnTCq01OGkQwBnG1MCtl67tqkji6EcpzsmHo2999OeCZe63oRwOsxHTUvpWtYp3-mmQ1U2GKVXB9RF0OZWScex3OWxt3vcM-kM2fc2m_5dNFbw7OS_DFv0jfgqjzt-f5rY4O43ZRhfKIyY7xrVoK2aO2K8w4f6Jpf3lt6v_TvgDNx6n-Q</recordid><startdate>199306</startdate><enddate>199306</enddate><creator>Hastings, Gillian Z.</creator><creator>Francis, Michael J.</creator><creator>Rowlands, D. J.</creator><creator>Chain, Benjamin M.</creator><general>WILEY‐VCH Verlag GmbH</general><general>Wiley-VCH</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>199306</creationdate><title>Antigen processing and presentation of human rhinovirus to CD4 T cells is facilitated by binding to cellular receptors for virus</title><author>Hastings, Gillian Z. ; Francis, Michael J. ; Rowlands, D. J. ; Chain, Benjamin M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4003-1c84e9e34723236bd0ad8653d13c69736660c49e00c9115b2ad4c7884e4efdf43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adjuvants, Immunologic</topic><topic>Animals</topic><topic>Antigen processing</topic><topic>Antigen-Presenting Cells - immunology</topic><topic>Biological and medical sciences</topic><topic>CD4 antigen presentation</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>Cells, Cultured</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>HeLa Cells</topic><topic>Human rhinovirus</topic><topic>Humans</topic><topic>Immunobiology</topic><topic>In Vitro Techniques</topic><topic>Lymphocyte Activation</topic><topic>Mice</topic><topic>Modulation of the immune response (stimulation, suppression)</topic><topic>Neutralization Tests</topic><topic>Receptors, Virus - metabolism</topic><topic>rhinovirus</topic><topic>Rhinovirus - immunology</topic><topic>Rhinovirus - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hastings, Gillian Z.</creatorcontrib><creatorcontrib>Francis, Michael J.</creatorcontrib><creatorcontrib>Rowlands, D. 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J.</au><au>Chain, Benjamin M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antigen processing and presentation of human rhinovirus to CD4 T cells is facilitated by binding to cellular receptors for virus</atitle><jtitle>European journal of immunology</jtitle><addtitle>Eur J Immunol</addtitle><date>1993-06</date><risdate>1993</risdate><volume>23</volume><issue>6</issue><spage>1340</spage><epage>1345</epage><pages>1340-1345</pages><issn>0014-2980</issn><eissn>1521-4141</eissn><coden>EJIMAF</coden><abstract>Human rhinovirus serotypes (HRV) fall into two distinct groups, major and minor, by virtue of their cell receptor‐binding ability. In this study minor receptor‐binding group viruses are demonstrated to bind directly to cells of the murine immune system, including lymphoid dendritic cells which act as antigen‐presenting cells, although they do not produce a productive infection in murine cells. This binding is specific and can be blocked by other serotypes of minor‐group HRV Pre‐treatment of HRV 1A, a minor‐group virus, with HRV 1A‐specific antibodies inhibited the cellular proliferation of murine virus primed T helper cells, whereas antibody treatment of HRV 15, a non‐binding major serotype, gave no inhibition. The cell binding ability of minor‐group HRV played a role in the overall immunogenicity of this virus group, which was shown to be enhanced compared to the immunogenicity of major‐group viruses in mice.</abstract><cop>Weinheim</cop><pub>WILEY‐VCH Verlag GmbH</pub><pmid>8099015</pmid><doi>10.1002/eji.1830230623</doi><tpages>6</tpages></addata></record> |
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| ispartof | European journal of immunology, 1993-06, Vol.23 (6), p.1340-1345 |
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| language | eng |
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| subjects | Adjuvants, Immunologic Animals Antigen processing Antigen-Presenting Cells - immunology Biological and medical sciences CD4 antigen presentation CD4-Positive T-Lymphocytes - immunology Cells, Cultured Fundamental and applied biological sciences. Psychology Fundamental immunology HeLa Cells Human rhinovirus Humans Immunobiology In Vitro Techniques Lymphocyte Activation Mice Modulation of the immune response (stimulation, suppression) Neutralization Tests Receptors, Virus - metabolism rhinovirus Rhinovirus - immunology Rhinovirus - metabolism |
| title | Antigen processing and presentation of human rhinovirus to CD4 T cells is facilitated by binding to cellular receptors for virus |
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