Intra-myocyte ion homeostasis during ischemia-reperfusion injury: effects of pharmacologic preconditioning and controlled reperfusion

This study determines whether controlled reperfusion or diazoxide improves intramyocyte Na + homeostasis using a porcine model of severe ischemia-reperfusion injury. Three groups (n = 10 pigs per group) had 75 minutes of left anterior descending artery occlusion during bypass. Group 1 had no treatme...

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Veröffentlicht in:	The Annals of thoracic surgery 2003-10, Vol.76 (4), p.1252-1258
Hauptverfasser:	Davies, James E., Digerness, Stanley B., Goldberg, Steven P., Killingsworth, Cheryl R., Katholi, Charles R., Brookes, Paul S., Holman, William L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Diazoxide - pharmacology Female Homeostasis - drug effects Homeostasis - physiology Ischemic Preconditioning, Myocardial - methods Male Myocardial Reperfusion - methods Myocytes, Cardiac - metabolism Sodium - metabolism Swine Water-Electrolyte Balance - drug effects Water-Electrolyte Balance - physiology
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