Potencies and selectivities of inhibitors of acetylcholinesterase and its molecular forms in normal and Alzheimer's disease brain

Eight inhibitors of acetylcholinesterase (AChE), tacrine, bis-tacrine, donepezil, rivastigmine, galantamine, heptyl-physostigmine, TAK-147 and metrifonate, were compared with regard to their effects on AChE and butyrylcholinesterase (BuChE) in normal human brain cortex. Additionally, the IC50 values...

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Veröffentlicht in:	Acta biologica Hungarica 2003-01, Vol.54 (2), p.183-189
1. Verfasser:	Rakonczay, Z
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - metabolism Alzheimer Disease - enzymology Benzazepines - pharmacology Brain - drug effects Brain - enzymology Butyrylcholinesterase - metabolism Carbamates - pharmacology Cerebral Cortex - drug effects Cerebral Cortex - enzymology Cholinesterase Inhibitors - pharmacology Edrophonium - pharmacology Humans In Vitro Techniques Phenylcarbamates Physostigmine - analogs & derivatives Physostigmine - pharmacology Rivastigmine Tacrine - pharmacology Trichlorfon - pharmacology
Online-Zugang:	Volltext
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