GM3 as a Target of Anti-lymphocytic Ganglioside Antibodies in AIDS Patients
IgG antibodies reacting with the GM3-comigrating band extracted from pooled AIDS lymphocytes were detected in 33.3% of AIDS patients sera, in 8% of asymptomatic antiHIV-positive subjects, in none of the sero obtained from asymptomatic anti-HIV-negative drug abusers, from patients with acute B and ch...
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| Veröffentlicht in: | Clinical immunology and immunopathology 1993-06, Vol.67 (3), p.216-223 |
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| container_title | Clinical immunology and immunopathology |
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| creator | Misasi, R. Sorice, M. Griggi, T. D'Agostino, F. Garofalo, T. Masala, C. Pontieri, G.M. Lenti, L. |
| description | IgG antibodies reacting with the GM3-comigrating band extracted from pooled AIDS lymphocytes were detected in 33.3% of AIDS patients sera, in 8% of asymptomatic antiHIV-positive subjects, in none of the sero obtained from asymptomatic anti-HIV-negative drug abusers, from patients with acute B and chronic C hepatitis, and from healthy donors. All positive sero reacted selectively with the GM3-comigrating band obtained from AIDS lymphocytes but not with the corresponding band from normal lymphocytes. The lymphocytic ganglioside autoantigen was revealed as GM3. In addition, two main data were shown: (a) AIDS lymphocytes have an increased concentration of GM3 and (b) the ceramide of AIDS lymphocytic GM3 has a different percentual composition of fatty acids in contrast to control cells. It is suggested that these quantitative and qualitative changes might be responsible for the appearance of circulating anti-lymphocytic GM3 antibodies. |
| doi_str_mv | 10.1006/clin.1993.1068 |
| format | Article |
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All positive sero reacted selectively with the GM3-comigrating band obtained from AIDS lymphocytes but not with the corresponding band from normal lymphocytes. The lymphocytic ganglioside autoantigen was revealed as GM3. In addition, two main data were shown: (a) AIDS lymphocytes have an increased concentration of GM3 and (b) the ceramide of AIDS lymphocytic GM3 has a different percentual composition of fatty acids in contrast to control cells. It is suggested that these quantitative and qualitative changes might be responsible for the appearance of circulating anti-lymphocytic GM3 antibodies.</description><identifier>ISSN: 0090-1229</identifier><identifier>EISSN: 1090-2341</identifier><identifier>DOI: 10.1006/clin.1993.1068</identifier><identifier>PMID: 8500269</identifier><identifier>CODEN: CLIIAT</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Acquired Immunodeficiency Syndrome - blood ; Acquired Immunodeficiency Syndrome - immunology ; Adult ; AIDS/HIV ; Antilymphocyte Serum - blood ; Biological and medical sciences ; Carbohydrates - analysis ; Ceramides - analysis ; Chromatography, Gas ; Fatty Acids - blood ; Fatty Acids, Unsaturated - blood ; G(M3) Ganglioside - chemistry ; G(M3) Ganglioside - immunology ; Gangliosides - blood ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Lymphocytes - chemistry ; Male ; Medical sciences</subject><ispartof>Clinical immunology and immunopathology, 1993-06, Vol.67 (3), p.216-223</ispartof><rights>1993 Academic Press</rights><rights>1993 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-ee8be30e17f9a5ca9cc4c6953bed128c0d0d342e9abbb7c3dde2bff706275cf13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4776457$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8500269$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Misasi, R.</creatorcontrib><creatorcontrib>Sorice, M.</creatorcontrib><creatorcontrib>Griggi, T.</creatorcontrib><creatorcontrib>D'Agostino, F.</creatorcontrib><creatorcontrib>Garofalo, T.</creatorcontrib><creatorcontrib>Masala, C.</creatorcontrib><creatorcontrib>Pontieri, G.M.</creatorcontrib><creatorcontrib>Lenti, L.</creatorcontrib><title>GM3 as a Target of Anti-lymphocytic Ganglioside Antibodies in AIDS Patients</title><title>Clinical immunology and immunopathology</title><addtitle>Clin Immunol Immunopathol</addtitle><description>IgG antibodies reacting with the GM3-comigrating band extracted from pooled AIDS lymphocytes were detected in 33.3% of AIDS patients sera, in 8% of asymptomatic antiHIV-positive subjects, in none of the sero obtained from asymptomatic anti-HIV-negative drug abusers, from patients with acute B and chronic C hepatitis, and from healthy donors. All positive sero reacted selectively with the GM3-comigrating band obtained from AIDS lymphocytes but not with the corresponding band from normal lymphocytes. The lymphocytic ganglioside autoantigen was revealed as GM3. In addition, two main data were shown: (a) AIDS lymphocytes have an increased concentration of GM3 and (b) the ceramide of AIDS lymphocytic GM3 has a different percentual composition of fatty acids in contrast to control cells. It is suggested that these quantitative and qualitative changes might be responsible for the appearance of circulating anti-lymphocytic GM3 antibodies.</description><subject>Acquired Immunodeficiency Syndrome - blood</subject><subject>Acquired Immunodeficiency Syndrome - immunology</subject><subject>Adult</subject><subject>AIDS/HIV</subject><subject>Antilymphocyte Serum - blood</subject><subject>Biological and medical sciences</subject><subject>Carbohydrates - analysis</subject><subject>Ceramides - analysis</subject><subject>Chromatography, Gas</subject><subject>Fatty Acids - blood</subject><subject>Fatty Acids, Unsaturated - blood</subject><subject>G(M3) Ganglioside - chemistry</subject><subject>G(M3) Ganglioside - immunology</subject><subject>Gangliosides - blood</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Lymphocytes - chemistry</subject><subject>Male</subject><subject>Medical sciences</subject><issn>0090-1229</issn><issn>1090-2341</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtPwzAMhyMEGuNx5YaUA-LWkUfbNMeJx5gAgQSco9RxR1DXjqRD2n9PyyZunGzr99myPkLOOJtwxvIrqH0z4VrLfsyLPTLmTLNEyJTvkzEbei6EPiRHMX6yfiFlakRGRcaYyPWYPMyeJLWRWvpmwwI72lZ02nQ-qTfL1UcLm84DndlmUfs2eoe_Ydk6j5H6hk7nN6_0xXYemy6ekIPK1hFPd_WYvN_dvl3fJ4_Ps_n19DEBmRddgliUKBlyVWmbgdUAKeQ6kyU6LgpgjjmZCtS2LEsF0jkUZVUplguVQcXlMbnc3l2F9muNsTNLHwHr2jbYrqNRmcq40GkPTrYghDbGgJVZBb-0YWM4M4M9M9gzgz0z2OsXzneX1-US3R--09XnF7vcRrB1FWwDPv5hqVJ5mqkeK7YY9ha-PQYToTcE6HxA6Ixr_X8f_ABf_IrW</recordid><startdate>19930601</startdate><enddate>19930601</enddate><creator>Misasi, R.</creator><creator>Sorice, M.</creator><creator>Griggi, T.</creator><creator>D'Agostino, F.</creator><creator>Garofalo, T.</creator><creator>Masala, C.</creator><creator>Pontieri, G.M.</creator><creator>Lenti, L.</creator><general>Elsevier Inc</general><general>Academic Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930601</creationdate><title>GM3 as a Target of Anti-lymphocytic Ganglioside Antibodies in AIDS Patients</title><author>Misasi, R. ; Sorice, M. ; Griggi, T. ; D'Agostino, F. ; Garofalo, T. ; Masala, C. ; Pontieri, G.M. ; Lenti, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-ee8be30e17f9a5ca9cc4c6953bed128c0d0d342e9abbb7c3dde2bff706275cf13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Acquired Immunodeficiency Syndrome - blood</topic><topic>Acquired Immunodeficiency Syndrome - immunology</topic><topic>Adult</topic><topic>AIDS/HIV</topic><topic>Antilymphocyte Serum - blood</topic><topic>Biological and medical sciences</topic><topic>Carbohydrates - analysis</topic><topic>Ceramides - analysis</topic><topic>Chromatography, Gas</topic><topic>Fatty Acids - blood</topic><topic>Fatty Acids, Unsaturated - blood</topic><topic>G(M3) Ganglioside - chemistry</topic><topic>G(M3) Ganglioside - immunology</topic><topic>Gangliosides - blood</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Lymphocytes - chemistry</topic><topic>Male</topic><topic>Medical sciences</topic><toplevel>online_resources</toplevel><creatorcontrib>Misasi, R.</creatorcontrib><creatorcontrib>Sorice, M.</creatorcontrib><creatorcontrib>Griggi, T.</creatorcontrib><creatorcontrib>D'Agostino, F.</creatorcontrib><creatorcontrib>Garofalo, T.</creatorcontrib><creatorcontrib>Masala, C.</creatorcontrib><creatorcontrib>Pontieri, G.M.</creatorcontrib><creatorcontrib>Lenti, L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical immunology and immunopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Misasi, R.</au><au>Sorice, M.</au><au>Griggi, T.</au><au>D'Agostino, F.</au><au>Garofalo, T.</au><au>Masala, C.</au><au>Pontieri, G.M.</au><au>Lenti, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>GM3 as a Target of Anti-lymphocytic Ganglioside Antibodies in AIDS Patients</atitle><jtitle>Clinical immunology and immunopathology</jtitle><addtitle>Clin Immunol Immunopathol</addtitle><date>1993-06-01</date><risdate>1993</risdate><volume>67</volume><issue>3</issue><spage>216</spage><epage>223</epage><pages>216-223</pages><issn>0090-1229</issn><eissn>1090-2341</eissn><coden>CLIIAT</coden><abstract>IgG antibodies reacting with the GM3-comigrating band extracted from pooled AIDS lymphocytes were detected in 33.3% of AIDS patients sera, in 8% of asymptomatic antiHIV-positive subjects, in none of the sero obtained from asymptomatic anti-HIV-negative drug abusers, from patients with acute B and chronic C hepatitis, and from healthy donors. All positive sero reacted selectively with the GM3-comigrating band obtained from AIDS lymphocytes but not with the corresponding band from normal lymphocytes. The lymphocytic ganglioside autoantigen was revealed as GM3. In addition, two main data were shown: (a) AIDS lymphocytes have an increased concentration of GM3 and (b) the ceramide of AIDS lymphocytic GM3 has a different percentual composition of fatty acids in contrast to control cells. It is suggested that these quantitative and qualitative changes might be responsible for the appearance of circulating anti-lymphocytic GM3 antibodies.</abstract><cop>San Diego, CA</cop><cop>New York, NY</cop><cop>Boston</cop><pub>Elsevier Inc</pub><pmid>8500269</pmid><doi>10.1006/clin.1993.1068</doi><tpages>8</tpages></addata></record> |
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| ispartof | Clinical immunology and immunopathology, 1993-06, Vol.67 (3), p.216-223 |
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| subjects | Acquired Immunodeficiency Syndrome - blood Acquired Immunodeficiency Syndrome - immunology Adult AIDS/HIV Antilymphocyte Serum - blood Biological and medical sciences Carbohydrates - analysis Ceramides - analysis Chromatography, Gas Fatty Acids - blood Fatty Acids, Unsaturated - blood G(M3) Ganglioside - chemistry G(M3) Ganglioside - immunology Gangliosides - blood Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Lymphocytes - chemistry Male Medical sciences |
| title | GM3 as a Target of Anti-lymphocytic Ganglioside Antibodies in AIDS Patients |
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