Dynamics of Pathogenic and Suppressor T Cells in Autoimmune Diabetes Development

In the nonobese diabetic (NOD) mouse, pathogenic and suppressor CD4(+) T cells can be distinguished by the constitutive expression of CD25. In this study, we demonstrate that the progression of autoimmune diabetes in NOD mice reflects modifications in both T cell subsets. CD4(+)CD25(+) suppressor T...

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Veröffentlicht in:	The Journal of immunology (1950) 2003-10, Vol.171 (8), p.4040-4047
Hauptverfasser:	Gregori, Silvia, Giarratana, Nadia, Smiroldo, Simona, Adorini, Luciano
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Aging - immunology Animals Antibodies, Blocking - pharmacology Antibodies, Monoclonal - pharmacology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - pathology CD4-Positive T-Lymphocytes - transplantation Cell Communication - immunology Cell Separation Cells, Cultured Cytokines - biosynthesis Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - pathology Diabetes Mellitus, Type 1 - prevention & control Immunity, Innate Intercellular Adhesion Molecule-1 - biosynthesis Intercellular Adhesion Molecule-1 - immunology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred NOD Mice, SCID Receptors, Interleukin-2 - biosynthesis Species Specificity T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocyte Subsets - pathology T-Lymphocyte Subsets - transplantation T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism T-Lymphocytes, Regulatory - transplantation Up-Regulation - immunology
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