Mapping and sequencing of acetylcholinesterase genes from the platyhelminth blood fluke Schistosoma

Acetylcholinesterase (AChE) on the surface of the parasitic blood fluke Schistosoma is the likely target for schistosomicidal anticholinesterases. Determination of the molecular structure of this drug target is key for the development of improved anticholinesterase drugs and potentially a novel vacc...

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Veröffentlicht in:	Gene 2003-09, Vol.314, p.103-112
Hauptverfasser:	Bentley, Geoffrey N., Jones, Andrew K., Agnew, Alison
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - genetics AChE gene Amino Acid Sequence Animals Anticholinesterase DNA, Complementary - chemistry DNA, Complementary - genetics DNA, Helminth - chemistry DNA, Helminth - genetics Exon Exons Genes, Helminth - genetics GPI anchor Intron Introns metrifonate Molecular Sequence Data Phylogeny Schistosoma - enzymology Schistosoma - genetics Schistosoma bovis Schistosoma haematobium Schistosoma haematobium - enzymology Schistosoma haematobium - genetics Schistosoma mansoni Schistosoma mansoni - enzymology Schistosoma mansoni - genetics Sequence Alignment Sequence Analysis, DNA Sequence Homology, Amino Acid Species Specificity Trematode platyhelminth
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