Androgen concentration by a sexually dimorphic population of tachykinin-immunoreactive neurons in the rat ventral premammillary nucleus
Strong connections with sexually dimorphic nuclei suggest that the ventral premammillary nucleus (PMv) may be involved in the mediation of reproductive behavior. Steriod autoradiography and immunohistochemistry were used to show that: (i) there is a sex difference in the numbers of PMv neurons that...
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| Veröffentlicht in: | Brain research 1993-04, Vol.608 (2), p.319-323 |
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| creator | Akesson, Thomas R. |
| description | Strong connections with sexually dimorphic nuclei suggest that the ventral premammillary nucleus (PMv) may be involved in the mediation of reproductive behavior. Steriod autoradiography and immunohistochemistry were used to show that: (i) there is a sex difference in the numbers of PMv neurons that contain tachykinin peptides, (ii) dihydrotestosterone concentrating cells are densely distribution in the PMv and about a quarter of these also contain immunoreactive tachykinin and, (iii) size of the immunoreactive tachykinin population does not respond to alterations in levels of gonadal steroids in adulthood. Thus the PMv appears to make a contribution to the regulation of sexual behavior through androgen-concentrating, tachykinin-containing pathways that are anatomically distinct from estrogen receptive circuitry. |
| doi_str_mv | 10.1016/0006-8993(93)91473-6 |
| format | Article |
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Steriod autoradiography and immunohistochemistry were used to show that: (i) there is a sex difference in the numbers of PMv neurons that contain tachykinin peptides, (ii) dihydrotestosterone concentrating cells are densely distribution in the PMv and about a quarter of these also contain immunoreactive tachykinin and, (iii) size of the immunoreactive tachykinin population does not respond to alterations in levels of gonadal steroids in adulthood. Thus the PMv appears to make a contribution to the regulation of sexual behavior through androgen-concentrating, tachykinin-containing pathways that are anatomically distinct from estrogen receptive circuitry.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(93)91473-6</identifier><identifier>PMID: 8495366</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Androgens - metabolism ; Animals ; Autoradiography ; Biological and medical sciences ; Dihydrotestosterone ; Dihydrotestosterone - pharmacology ; Estrogen ; Female ; Fundamental and applied biological sciences. Psychology ; Hypothalamus. Hypophysis. Epiphysis. Urophysis ; Male ; Mammillary Bodies - cytology ; Mammillary Bodies - immunology ; Mammillary Bodies - physiology ; Morphology. Functional localizations ; Neurons - immunology ; Neurons - physiology ; Orchiectomy ; Ovariectomy ; Rats ; Sex Characteristics ; Sexual behavior ; Sexual Behavior, Animal - physiology ; Subtance P ; Tachykinins - immunology ; Tachykinins - physiology ; Vertebrates: endocrinology</subject><ispartof>Brain research, 1993-04, Vol.608 (2), p.319-323</ispartof><rights>1993 Elsevier Science Publishers B.V. 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Steriod autoradiography and immunohistochemistry were used to show that: (i) there is a sex difference in the numbers of PMv neurons that contain tachykinin peptides, (ii) dihydrotestosterone concentrating cells are densely distribution in the PMv and about a quarter of these also contain immunoreactive tachykinin and, (iii) size of the immunoreactive tachykinin population does not respond to alterations in levels of gonadal steroids in adulthood. Thus the PMv appears to make a contribution to the regulation of sexual behavior through androgen-concentrating, tachykinin-containing pathways that are anatomically distinct from estrogen receptive circuitry.</description><subject>Androgens - metabolism</subject><subject>Animals</subject><subject>Autoradiography</subject><subject>Biological and medical sciences</subject><subject>Dihydrotestosterone</subject><subject>Dihydrotestosterone - pharmacology</subject><subject>Estrogen</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hypothalamus. Hypophysis. Epiphysis. Urophysis</subject><subject>Male</subject><subject>Mammillary Bodies - cytology</subject><subject>Mammillary Bodies - immunology</subject><subject>Mammillary Bodies - physiology</subject><subject>Morphology. Functional localizations</subject><subject>Neurons - immunology</subject><subject>Neurons - physiology</subject><subject>Orchiectomy</subject><subject>Ovariectomy</subject><subject>Rats</subject><subject>Sex Characteristics</subject><subject>Sexual behavior</subject><subject>Sexual Behavior, Animal - physiology</subject><subject>Subtance P</subject><subject>Tachykinins - immunology</subject><subject>Tachykinins - physiology</subject><subject>Vertebrates: endocrinology</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2r1DAUhoMo1_HqP1DIQkQX1aRJ87ERLhe_4IIbXYf0JHWibVKTdnB-gX_b1BlmqRAI4Tzn5Zw8CD2l5DUlVLwhhIhGac1eavZKUy5ZI-6hHVWybUTLyX20uyAP0aNSvtcnY5pcoSvFdceE2KHfN9Hl9M1HDCmCj0u2S0gR90dscfG_VjuOR-zClPK8D4DnNK_jCUkDXizsjz9CDLEJ07TGlL2FJRw8jn7NKRYcIl72HtdUfPibPuI5-8lOUxhHm484rjD6tTxGDwY7Fv_kfF-jr-_ffbn92Nx9_vDp9uauAU7l0rTaSiJbwZ3teycH1YIdWiEBKPRS8ZYJPRBrdU8cVZxoBaxzynVWOQcDZ9foxSl3zunn6stiplDA11miT2sxspNcS_p_kIqOcdGqCvITCDmVkv1g5hymupqhxGyizGbBbBbMdjZRRtS2Z-f8tZ-8uzSdzdT683PdFrDjkG2EUC4YF5KQllXs7Qnz9dMOwWdTIPhq0oXsYTEuhX_P8QflhrMu</recordid><startdate>19930416</startdate><enddate>19930416</enddate><creator>Akesson, Thomas R.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19930416</creationdate><title>Androgen concentration by a sexually dimorphic population of tachykinin-immunoreactive neurons in the rat ventral premammillary nucleus</title><author>Akesson, Thomas R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-29a707264dabbd7f82caf267cc1cb7842369f0aa9b0d184098c35d8d5a8ddcf43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Androgens - metabolism</topic><topic>Animals</topic><topic>Autoradiography</topic><topic>Biological and medical sciences</topic><topic>Dihydrotestosterone</topic><topic>Dihydrotestosterone - pharmacology</topic><topic>Estrogen</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hypothalamus. Hypophysis. Epiphysis. Urophysis</topic><topic>Male</topic><topic>Mammillary Bodies - cytology</topic><topic>Mammillary Bodies - immunology</topic><topic>Mammillary Bodies - physiology</topic><topic>Morphology. Functional localizations</topic><topic>Neurons - immunology</topic><topic>Neurons - physiology</topic><topic>Orchiectomy</topic><topic>Ovariectomy</topic><topic>Rats</topic><topic>Sex Characteristics</topic><topic>Sexual behavior</topic><topic>Sexual Behavior, Animal - physiology</topic><topic>Subtance P</topic><topic>Tachykinins - immunology</topic><topic>Tachykinins - physiology</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akesson, Thomas R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akesson, Thomas R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Androgen concentration by a sexually dimorphic population of tachykinin-immunoreactive neurons in the rat ventral premammillary nucleus</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1993-04-16</date><risdate>1993</risdate><volume>608</volume><issue>2</issue><spage>319</spage><epage>323</epage><pages>319-323</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Strong connections with sexually dimorphic nuclei suggest that the ventral premammillary nucleus (PMv) may be involved in the mediation of reproductive behavior. Steriod autoradiography and immunohistochemistry were used to show that: (i) there is a sex difference in the numbers of PMv neurons that contain tachykinin peptides, (ii) dihydrotestosterone concentrating cells are densely distribution in the PMv and about a quarter of these also contain immunoreactive tachykinin and, (iii) size of the immunoreactive tachykinin population does not respond to alterations in levels of gonadal steroids in adulthood. Thus the PMv appears to make a contribution to the regulation of sexual behavior through androgen-concentrating, tachykinin-containing pathways that are anatomically distinct from estrogen receptive circuitry.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>8495366</pmid><doi>10.1016/0006-8993(93)91473-6</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; ScienceDirect Freedom Collection (Elsevier) |
| subjects | Androgens - metabolism Animals Autoradiography Biological and medical sciences Dihydrotestosterone Dihydrotestosterone - pharmacology Estrogen Female Fundamental and applied biological sciences. Psychology Hypothalamus. Hypophysis. Epiphysis. Urophysis Male Mammillary Bodies - cytology Mammillary Bodies - immunology Mammillary Bodies - physiology Morphology. Functional localizations Neurons - immunology Neurons - physiology Orchiectomy Ovariectomy Rats Sex Characteristics Sexual behavior Sexual Behavior, Animal - physiology Subtance P Tachykinins - immunology Tachykinins - physiology Vertebrates: endocrinology |
| title | Androgen concentration by a sexually dimorphic population of tachykinin-immunoreactive neurons in the rat ventral premammillary nucleus |
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