THE RNA POLYMERASE II ELONGATION COMPLEX
Synthesis of eukaryotic mRNA by RNA polymerase II is an elaborate biochemical process that requires the concerted action of a large set of transcription factors. RNA polymerase II transcription proceeds through multiple stages designated preinitiation, initiation, and elongation. Historically, studi...
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| Veröffentlicht in: | Annual review of biochemistry 2003-01, Vol.72 (1), p.693-715 |
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| creator | Shilatifard, Ali Conaway, Ronald C Conaway, Joan Weliky |
| description | Synthesis of eukaryotic mRNA by RNA polymerase II is an elaborate
biochemical process that requires the concerted action of a large set of
transcription factors. RNA polymerase II transcription proceeds through
multiple stages designated preinitiation, initiation, and elongation.
Historically, studies of the elongation stage of eukaryotic mRNA synthesis have
lagged behind studies of the preinitiation and initiation stages; however, in
recent years, efforts to elucidate the mechanisms governing elongation have led
to the discovery of a diverse collection of transcription factors that directly
regulate the activity of elongating RNA polymerase II. Moreover, these studies
have revealed unanticipated roles for the RNA polymerase II elongation complex
in such processes as DNA repair and recombination and the proper processing and
nucleocytoplasmic transport of mRNA. Below we describe these recent advances,
which highlight the important role of the RNA polymerase II elongation complex
in regulation of eukaryotic gene expression. |
| doi_str_mv | 10.1146/annurev.biochem.72.121801.161551 |
| format | Article |
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biochemical process that requires the concerted action of a large set of
transcription factors. RNA polymerase II transcription proceeds through
multiple stages designated preinitiation, initiation, and elongation.
Historically, studies of the elongation stage of eukaryotic mRNA synthesis have
lagged behind studies of the preinitiation and initiation stages; however, in
recent years, efforts to elucidate the mechanisms governing elongation have led
to the discovery of a diverse collection of transcription factors that directly
regulate the activity of elongating RNA polymerase II. Moreover, these studies
have revealed unanticipated roles for the RNA polymerase II elongation complex
in such processes as DNA repair and recombination and the proper processing and
nucleocytoplasmic transport of mRNA. Below we describe these recent advances,
which highlight the important role of the RNA polymerase II elongation complex
in regulation of eukaryotic gene expression.</description><identifier>ISSN: 0066-4154</identifier><identifier>EISSN: 1545-4509</identifier><identifier>DOI: 10.1146/annurev.biochem.72.121801.161551</identifier><identifier>PMID: 12676794</identifier><identifier>CODEN: ARBOAW</identifier><language>eng</language><publisher>Palo Alto, CA 94303-0139: Annual Reviews</publisher><subject>chromatin ; Chromatin - metabolism ; DSIF ; ELL ; Elongator ; Elongin ; Eukaryotic Cells - physiology ; FACT ; Gene Expression Regulation - genetics ; Models, Molecular ; NELF ; P-TEFb ; Polymers ; Ribonucleic acid ; RNA ; RNA polymerase II ; RNA Polymerase II - chemistry ; RNA, Messenger - biosynthesis ; SII ; THO complex ; Transcription Factors - chemistry ; Transcription Factors - physiology</subject><ispartof>Annual review of biochemistry, 2003-01, Vol.72 (1), p.693-715</ispartof><rights>Copyright © 2003 by Annual Reviews. All rights reserved</rights><rights>Copyright Annual Reviews, Inc. 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a513t-55ef39888dea7ed23060574d6f8e83812b7c36c5ce62490332d4892d8297379a3</citedby><cites>FETCH-LOGICAL-a513t-55ef39888dea7ed23060574d6f8e83812b7c36c5ce62490332d4892d8297379a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev.biochem.72.121801.161551?crawler=true&mimetype=application/pdf$$EPDF$$P50$$Gannualreviews$$H</linktopdf><linktohtml>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev.biochem.72.121801.161551$$EHTML$$P50$$Gannualreviews$$H</linktohtml><link.rule.ids>70,314,776,780,4168,27901,27902,78223,78224</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12676794$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shilatifard, Ali</creatorcontrib><creatorcontrib>Conaway, Ronald C</creatorcontrib><creatorcontrib>Conaway, Joan Weliky</creatorcontrib><title>THE RNA POLYMERASE II ELONGATION COMPLEX</title><title>Annual review of biochemistry</title><addtitle>Annu Rev Biochem</addtitle><description>Synthesis of eukaryotic mRNA by RNA polymerase II is an elaborate
biochemical process that requires the concerted action of a large set of
transcription factors. RNA polymerase II transcription proceeds through
multiple stages designated preinitiation, initiation, and elongation.
Historically, studies of the elongation stage of eukaryotic mRNA synthesis have
lagged behind studies of the preinitiation and initiation stages; however, in
recent years, efforts to elucidate the mechanisms governing elongation have led
to the discovery of a diverse collection of transcription factors that directly
regulate the activity of elongating RNA polymerase II. Moreover, these studies
have revealed unanticipated roles for the RNA polymerase II elongation complex
in such processes as DNA repair and recombination and the proper processing and
nucleocytoplasmic transport of mRNA. Below we describe these recent advances,
which highlight the important role of the RNA polymerase II elongation complex
in regulation of eukaryotic gene expression.</description><subject>chromatin</subject><subject>Chromatin - metabolism</subject><subject>DSIF</subject><subject>ELL</subject><subject>Elongator</subject><subject>Elongin</subject><subject>Eukaryotic Cells - physiology</subject><subject>FACT</subject><subject>Gene Expression Regulation - genetics</subject><subject>Models, Molecular</subject><subject>NELF</subject><subject>P-TEFb</subject><subject>Polymers</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA polymerase II</subject><subject>RNA Polymerase II - chemistry</subject><subject>RNA, Messenger - biosynthesis</subject><subject>SII</subject><subject>THO complex</subject><subject>Transcription Factors - chemistry</subject><subject>Transcription Factors - physiology</subject><issn>0066-4154</issn><issn>1545-4509</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqVkMtKw0AUQAdRbK3-ggQX0k3ivB87Q4ltIDalVtDVkCZTbGmammkU_94pCQhuxNWFy-Fc7gFgiGCAEOV32W7X1OYjWK6r_M2UgcABwkhCFCCOGEMnoI8YZT5lUJ2CPoSc-9RteuDC2g2EkCiKz0EPYS64ULQPhotJ5M2noTdLk9fHaB4-RV4ce1GSTsfhIk6n3ih9nCXRyyU4W2Vba666OQDPD9FiNPGTdByPwsTPGCIHnzGzIkpKWZhMmAITyCETtOAraSSRCC9FTnjOcsMxVZAQXFCpcCGxEkSojAzAbevd19V7Y-xBl2ubm-0225mqsVo4m-KS_wkiKZHilDrw5he4qZp6557QGBOuCOHYQfctlNeVtbVZ6X29LrP6SyOoj-1111537bXAum2v2_ZOcd3daZalKX4EXWwHRC1wVGVbJ1ubT_v_Q9_mnJXV</recordid><startdate>20030101</startdate><enddate>20030101</enddate><creator>Shilatifard, Ali</creator><creator>Conaway, Ronald C</creator><creator>Conaway, Joan Weliky</creator><general>Annual Reviews</general><general>Annual Reviews, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PCBAR</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20030101</creationdate><title>THE RNA POLYMERASE II ELONGATION COMPLEX</title><author>Shilatifard, Ali ; Conaway, Ronald C ; Conaway, Joan Weliky</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a513t-55ef39888dea7ed23060574d6f8e83812b7c36c5ce62490332d4892d8297379a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>chromatin</topic><topic>Chromatin - metabolism</topic><topic>DSIF</topic><topic>ELL</topic><topic>Elongator</topic><topic>Elongin</topic><topic>Eukaryotic Cells - physiology</topic><topic>FACT</topic><topic>Gene Expression Regulation - genetics</topic><topic>Models, Molecular</topic><topic>NELF</topic><topic>P-TEFb</topic><topic>Polymers</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>RNA polymerase II</topic><topic>RNA Polymerase II - chemistry</topic><topic>RNA, Messenger - biosynthesis</topic><topic>SII</topic><topic>THO complex</topic><topic>Transcription Factors - chemistry</topic><topic>Transcription Factors - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shilatifard, Ali</creatorcontrib><creatorcontrib>Conaway, Ronald C</creatorcontrib><creatorcontrib>Conaway, Joan Weliky</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Annual review of biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shilatifard, Ali</au><au>Conaway, Ronald C</au><au>Conaway, Joan Weliky</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>THE RNA POLYMERASE II ELONGATION COMPLEX</atitle><jtitle>Annual review of biochemistry</jtitle><addtitle>Annu Rev Biochem</addtitle><date>2003-01-01</date><risdate>2003</risdate><volume>72</volume><issue>1</issue><spage>693</spage><epage>715</epage><pages>693-715</pages><issn>0066-4154</issn><eissn>1545-4509</eissn><coden>ARBOAW</coden><abstract>Synthesis of eukaryotic mRNA by RNA polymerase II is an elaborate
biochemical process that requires the concerted action of a large set of
transcription factors. RNA polymerase II transcription proceeds through
multiple stages designated preinitiation, initiation, and elongation.
Historically, studies of the elongation stage of eukaryotic mRNA synthesis have
lagged behind studies of the preinitiation and initiation stages; however, in
recent years, efforts to elucidate the mechanisms governing elongation have led
to the discovery of a diverse collection of transcription factors that directly
regulate the activity of elongating RNA polymerase II. Moreover, these studies
have revealed unanticipated roles for the RNA polymerase II elongation complex
in such processes as DNA repair and recombination and the proper processing and
nucleocytoplasmic transport of mRNA. Below we describe these recent advances,
which highlight the important role of the RNA polymerase II elongation complex
in regulation of eukaryotic gene expression.</abstract><cop>Palo Alto, CA 94303-0139</cop><cop>4139 El Camino Way, P.O. Box 10139</cop><cop>USA</cop><pub>Annual Reviews</pub><pmid>12676794</pmid><doi>10.1146/annurev.biochem.72.121801.161551</doi><tpages>23</tpages></addata></record> |
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| identifier | ISSN: 0066-4154 |
| ispartof | Annual review of biochemistry, 2003-01, Vol.72 (1), p.693-715 |
| issn | 0066-4154 1545-4509 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75749686 |
| source | Annual Reviews Complete A-Z List; MEDLINE |
| subjects | chromatin Chromatin - metabolism DSIF ELL Elongator Elongin Eukaryotic Cells - physiology FACT Gene Expression Regulation - genetics Models, Molecular NELF P-TEFb Polymers Ribonucleic acid RNA RNA polymerase II RNA Polymerase II - chemistry RNA, Messenger - biosynthesis SII THO complex Transcription Factors - chemistry Transcription Factors - physiology |
| title | THE RNA POLYMERASE II ELONGATION COMPLEX |
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