The Hemopoietic Rho/Rac Guanine Nucleotide Exchange Factor Vav1 Regulates N-Formyl-Methionyl-Leucyl-Phenylalanine-Activated Neutrophil Functions

Vav1 is a hemopoietic-specific Rho/Rac guanine nucleotide exchange factor that plays a prominent role in responses to multisubunit immune recognition receptors in lymphoid cells, but its contribution to regulation of neutrophil functions is unknown. Activated Rho family GTPases are critical particip...

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Veröffentlicht in:	The Journal of immunology (1950) 2003-10, Vol.171 (8), p.4425-4430
Hauptverfasser:	Kim, Chaekyun, Marchal, Christophe C, Penninger, Josef, Dinauer, Mary C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Cycle Proteins Cell Separation Guanine Nucleotide Exchange Factors - metabolism Guanine Nucleotide Exchange Factors - physiology Hematopoiesis - genetics Hematopoiesis - physiology Mice Mice, Inbred C57BL Mice, Knockout N-Formylmethionine Leucyl-Phenylalanine - pharmacology NADPH Oxidases - metabolism Neutrophil Activation - genetics Neutrophil Activation - physiology Neutrophils - enzymology Neutrophils - metabolism Neutrophils - physiology Phosphotyrosine - metabolism Proto-Oncogene Proteins - deficiency Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins - physiology Proto-Oncogene Proteins c-vav rac GTP-Binding Proteins - metabolism rac GTP-Binding Proteins - physiology rho GTP-Binding Proteins - metabolism rho GTP-Binding Proteins - physiology Signal Transduction - genetics Signal Transduction - physiology
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