Neuroprotective Effects of Gabapentin in Experimental Spinal Cord Injury
Background Extensive research has focused on neuroprotection after spinal cord trauma to alleviate the effects of secondary injury. This study aims to investigate the neuroprotective effects of gabapentin in experimental spinal cord injury. Methods Thirty-six adult, male Wistar rats received spinal...
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| Veröffentlicht in: | World neurosurgery 2010-06, Vol.73 (6), p.729-734 |
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| creator | Emmez, Hakan Börcek, Alp Özgün Kaymaz, Memduh Kaymaz, Figen Durdağ, Emre Çivi, Soner Gülbahar, Özlem Aykol, Şükrü Paşaoğlu, Aydın |
| description | Background Extensive research has focused on neuroprotection after spinal cord trauma to alleviate the effects of secondary injury. This study aims to investigate the neuroprotective effects of gabapentin in experimental spinal cord injury. Methods Thirty-six adult, male Wistar rats received spinal cord injury using the clip compression method. Animals were divided into five groups. High (200 mg/kg) and low doses (30 mg/kg) of gabapentin were administered to the animals in the treatment groups after spinal cord trauma and ultrastructural findings and lipid peroxidation levels of these two groups were compared with the animals that received only laminectomy, only trauma, and trauma and 30 mg/kg methylprednisolone. Results Regarding tissue lipid peroxidation levels after trauma, animals in gabapentin groups demonstrated better results than the trauma group. However, these results were no better than the methylprednisolone group. The results regarding the ultrastructural findings were similar. Treatment groups demonstrated better ultrastructural findings than the trauma group. In addition, the results of the high dose gabapentin group were significantly better than the low dose gabapentin group. Conclusions Gabapentin demonstrated similar neuroprotective effects as methylprednisolone in early phase of spinal cord injury. Further studies with different experimental settings including neurological outcome are required to achieve conclusive results. |
| doi_str_mv | 10.1016/j.wneu.2010.04.008 |
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This study aims to investigate the neuroprotective effects of gabapentin in experimental spinal cord injury. Methods Thirty-six adult, male Wistar rats received spinal cord injury using the clip compression method. Animals were divided into five groups. High (200 mg/kg) and low doses (30 mg/kg) of gabapentin were administered to the animals in the treatment groups after spinal cord trauma and ultrastructural findings and lipid peroxidation levels of these two groups were compared with the animals that received only laminectomy, only trauma, and trauma and 30 mg/kg methylprednisolone. Results Regarding tissue lipid peroxidation levels after trauma, animals in gabapentin groups demonstrated better results than the trauma group. However, these results were no better than the methylprednisolone group. The results regarding the ultrastructural findings were similar. Treatment groups demonstrated better ultrastructural findings than the trauma group. In addition, the results of the high dose gabapentin group were significantly better than the low dose gabapentin group. Conclusions Gabapentin demonstrated similar neuroprotective effects as methylprednisolone in early phase of spinal cord injury. Further studies with different experimental settings including neurological outcome are required to achieve conclusive results.</description><identifier>ISSN: 1878-8750</identifier><identifier>EISSN: 1878-8769</identifier><identifier>DOI: 10.1016/j.wneu.2010.04.008</identifier><identifier>PMID: 20934165</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Amines - pharmacology ; Amines - therapeutic use ; Animals ; Biological and medical sciences ; Calcium Channel Blockers - pharmacology ; Calcium Channel Blockers - therapeutic use ; Calcium Channels, L-Type - drug effects ; Calcium Channels, L-Type - physiology ; Cyclohexanecarboxylic Acids - pharmacology ; Cyclohexanecarboxylic Acids - therapeutic use ; Disease Models, Animal ; Excitatory Amino Acid Antagonists - pharmacology ; Excitatory Amino Acid Antagonists - therapeutic use ; GABA Agonists - pharmacology ; GABA Agonists - therapeutic use ; Gabapentin ; gamma-Aminobutyric Acid - pharmacology ; gamma-Aminobutyric Acid - therapeutic use ; Male ; Medical sciences ; Neuroprotection ; Neuroprotective Agents - pharmacology ; Neuroprotective Agents - therapeutic use ; Neurosurgery ; Random Allocation ; Rats ; Rats, Wistar ; Spinal Cord Injuries - drug therapy ; Spinal Cord Injuries - pathology ; Spinal Cord Injuries - physiopathology ; Spinal cord injury ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Treatment Outcome</subject><ispartof>World neurosurgery, 2010-06, Vol.73 (6), p.729-734</ispartof><rights>Elsevier Inc.</rights><rights>2010 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-9042aed096d11e81f43872648f89397a46408fd4d50e6e8c4e1161d9f0d90f433</citedby><cites>FETCH-LOGICAL-c440t-9042aed096d11e81f43872648f89397a46408fd4d50e6e8c4e1161d9f0d90f433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.wneu.2010.04.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23346963$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20934165$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Emmez, Hakan</creatorcontrib><creatorcontrib>Börcek, Alp Özgün</creatorcontrib><creatorcontrib>Kaymaz, Memduh</creatorcontrib><creatorcontrib>Kaymaz, Figen</creatorcontrib><creatorcontrib>Durdağ, Emre</creatorcontrib><creatorcontrib>Çivi, Soner</creatorcontrib><creatorcontrib>Gülbahar, Özlem</creatorcontrib><creatorcontrib>Aykol, Şükrü</creatorcontrib><creatorcontrib>Paşaoğlu, Aydın</creatorcontrib><title>Neuroprotective Effects of Gabapentin in Experimental Spinal Cord Injury</title><title>World neurosurgery</title><addtitle>World Neurosurg</addtitle><description>Background Extensive research has focused on neuroprotection after spinal cord trauma to alleviate the effects of secondary injury. This study aims to investigate the neuroprotective effects of gabapentin in experimental spinal cord injury. Methods Thirty-six adult, male Wistar rats received spinal cord injury using the clip compression method. Animals were divided into five groups. High (200 mg/kg) and low doses (30 mg/kg) of gabapentin were administered to the animals in the treatment groups after spinal cord trauma and ultrastructural findings and lipid peroxidation levels of these two groups were compared with the animals that received only laminectomy, only trauma, and trauma and 30 mg/kg methylprednisolone. Results Regarding tissue lipid peroxidation levels after trauma, animals in gabapentin groups demonstrated better results than the trauma group. However, these results were no better than the methylprednisolone group. The results regarding the ultrastructural findings were similar. Treatment groups demonstrated better ultrastructural findings than the trauma group. In addition, the results of the high dose gabapentin group were significantly better than the low dose gabapentin group. Conclusions Gabapentin demonstrated similar neuroprotective effects as methylprednisolone in early phase of spinal cord injury. Further studies with different experimental settings including neurological outcome are required to achieve conclusive results.</description><subject>Amines - pharmacology</subject><subject>Amines - therapeutic use</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Calcium Channel Blockers - pharmacology</subject><subject>Calcium Channel Blockers - therapeutic use</subject><subject>Calcium Channels, L-Type - drug effects</subject><subject>Calcium Channels, L-Type - physiology</subject><subject>Cyclohexanecarboxylic Acids - pharmacology</subject><subject>Cyclohexanecarboxylic Acids - therapeutic use</subject><subject>Disease Models, Animal</subject><subject>Excitatory Amino Acid Antagonists - pharmacology</subject><subject>Excitatory Amino Acid Antagonists - therapeutic use</subject><subject>GABA Agonists - pharmacology</subject><subject>GABA Agonists - therapeutic use</subject><subject>Gabapentin</subject><subject>gamma-Aminobutyric Acid - pharmacology</subject><subject>gamma-Aminobutyric Acid - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuroprotection</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Neuroprotective Agents - therapeutic use</subject><subject>Neurosurgery</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Spinal Cord Injuries - drug therapy</subject><subject>Spinal Cord Injuries - pathology</subject><subject>Spinal Cord Injuries - physiopathology</subject><subject>Spinal cord injury</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Treatment Outcome</subject><issn>1878-8750</issn><issn>1878-8769</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kVFrFDEUhQdRbKn9Az7IvIhPu95MspkERJBlbQtFH6rPIU1uIONsZkxmWvffe4ddK_hgCOQmnHtz-E5VvWawZsDk-279mHBeN0APINYA6ll1zlSrVqqV-vlTvYGz6rKUDmhxJlTLX1ZnDWgumNycV9dfcM7DmIcJ3RQfsN6FQFWph1Bf2Xs7Yppiqmnvfo2Y457utq_vxpjo2A7Z1zepm_PhVfUi2L7g5em8qL5_3n3bXq9uv17dbD_drpwQMK00iMaiBy09Y6hYEFy1jRQqKM11a4UUoIIXfgMoUTmBjEnmdQCvgcT8onp3nEuef85YJrOPxWHf24TDXEy7aWlGK4CUzVHp8lBKxmBG8m_zwTAwC0PTmYWhWRgaEIYYUtOb0_j5fo_-qeUPMRK8PQlscbYP2SYXy18d50Jqufj8cNQhwXiImE1xEZNDHzMBNn6I__fx8Z9218cU6ccfeMDSDXOmAIphpjQGzN2S9hI2o5iZAsF_Ay2IowE</recordid><startdate>20100601</startdate><enddate>20100601</enddate><creator>Emmez, Hakan</creator><creator>Börcek, Alp Özgün</creator><creator>Kaymaz, Memduh</creator><creator>Kaymaz, Figen</creator><creator>Durdağ, Emre</creator><creator>Çivi, Soner</creator><creator>Gülbahar, Özlem</creator><creator>Aykol, Şükrü</creator><creator>Paşaoğlu, Aydın</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100601</creationdate><title>Neuroprotective Effects of Gabapentin in Experimental Spinal Cord Injury</title><author>Emmez, Hakan ; Börcek, Alp Özgün ; Kaymaz, Memduh ; Kaymaz, Figen ; Durdağ, Emre ; Çivi, Soner ; Gülbahar, Özlem ; Aykol, Şükrü ; Paşaoğlu, Aydın</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-9042aed096d11e81f43872648f89397a46408fd4d50e6e8c4e1161d9f0d90f433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Amines - pharmacology</topic><topic>Amines - therapeutic use</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Calcium Channel Blockers - pharmacology</topic><topic>Calcium Channel Blockers - therapeutic use</topic><topic>Calcium Channels, L-Type - drug effects</topic><topic>Calcium Channels, L-Type - physiology</topic><topic>Cyclohexanecarboxylic Acids - pharmacology</topic><topic>Cyclohexanecarboxylic Acids - therapeutic use</topic><topic>Disease Models, Animal</topic><topic>Excitatory Amino Acid Antagonists - pharmacology</topic><topic>Excitatory Amino Acid Antagonists - therapeutic use</topic><topic>GABA Agonists - pharmacology</topic><topic>GABA Agonists - therapeutic use</topic><topic>Gabapentin</topic><topic>gamma-Aminobutyric Acid - pharmacology</topic><topic>gamma-Aminobutyric Acid - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuroprotection</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>Neuroprotective Agents - therapeutic use</topic><topic>Neurosurgery</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Spinal Cord Injuries - drug therapy</topic><topic>Spinal Cord Injuries - pathology</topic><topic>Spinal Cord Injuries - physiopathology</topic><topic>Spinal cord injury</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Emmez, Hakan</creatorcontrib><creatorcontrib>Börcek, Alp Özgün</creatorcontrib><creatorcontrib>Kaymaz, Memduh</creatorcontrib><creatorcontrib>Kaymaz, Figen</creatorcontrib><creatorcontrib>Durdağ, Emre</creatorcontrib><creatorcontrib>Çivi, Soner</creatorcontrib><creatorcontrib>Gülbahar, Özlem</creatorcontrib><creatorcontrib>Aykol, Şükrü</creatorcontrib><creatorcontrib>Paşaoğlu, Aydın</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>World neurosurgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Emmez, Hakan</au><au>Börcek, Alp Özgün</au><au>Kaymaz, Memduh</au><au>Kaymaz, Figen</au><au>Durdağ, Emre</au><au>Çivi, Soner</au><au>Gülbahar, Özlem</au><au>Aykol, Şükrü</au><au>Paşaoğlu, Aydın</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuroprotective Effects of Gabapentin in Experimental Spinal Cord Injury</atitle><jtitle>World neurosurgery</jtitle><addtitle>World Neurosurg</addtitle><date>2010-06-01</date><risdate>2010</risdate><volume>73</volume><issue>6</issue><spage>729</spage><epage>734</epage><pages>729-734</pages><issn>1878-8750</issn><eissn>1878-8769</eissn><abstract>Background Extensive research has focused on neuroprotection after spinal cord trauma to alleviate the effects of secondary injury. This study aims to investigate the neuroprotective effects of gabapentin in experimental spinal cord injury. Methods Thirty-six adult, male Wistar rats received spinal cord injury using the clip compression method. Animals were divided into five groups. High (200 mg/kg) and low doses (30 mg/kg) of gabapentin were administered to the animals in the treatment groups after spinal cord trauma and ultrastructural findings and lipid peroxidation levels of these two groups were compared with the animals that received only laminectomy, only trauma, and trauma and 30 mg/kg methylprednisolone. Results Regarding tissue lipid peroxidation levels after trauma, animals in gabapentin groups demonstrated better results than the trauma group. However, these results were no better than the methylprednisolone group. The results regarding the ultrastructural findings were similar. Treatment groups demonstrated better ultrastructural findings than the trauma group. In addition, the results of the high dose gabapentin group were significantly better than the low dose gabapentin group. Conclusions Gabapentin demonstrated similar neuroprotective effects as methylprednisolone in early phase of spinal cord injury. Further studies with different experimental settings including neurological outcome are required to achieve conclusive results.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>20934165</pmid><doi>10.1016/j.wneu.2010.04.008</doi><tpages>6</tpages></addata></record> |
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| subjects | Amines - pharmacology Amines - therapeutic use Animals Biological and medical sciences Calcium Channel Blockers - pharmacology Calcium Channel Blockers - therapeutic use Calcium Channels, L-Type - drug effects Calcium Channels, L-Type - physiology Cyclohexanecarboxylic Acids - pharmacology Cyclohexanecarboxylic Acids - therapeutic use Disease Models, Animal Excitatory Amino Acid Antagonists - pharmacology Excitatory Amino Acid Antagonists - therapeutic use GABA Agonists - pharmacology GABA Agonists - therapeutic use Gabapentin gamma-Aminobutyric Acid - pharmacology gamma-Aminobutyric Acid - therapeutic use Male Medical sciences Neuroprotection Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Neurosurgery Random Allocation Rats Rats, Wistar Spinal Cord Injuries - drug therapy Spinal Cord Injuries - pathology Spinal Cord Injuries - physiopathology Spinal cord injury Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Treatment Outcome |
| title | Neuroprotective Effects of Gabapentin in Experimental Spinal Cord Injury |
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