Proteomic analysis reveals a novel mechanism induced by the leukemic oncogene Tel/PDGFRβ in stem cells: Activation of the interferon response pathways

Objective proteomic analysis offers opportunities for hypothesis generation on molecular events associated with pathogenesis in stem cells. Relative quantification mass spectrometry was employed to identify pathways affected by Tel/PDGFRβ, an oncogene associated with myeloproliferative neoplasia (MP...

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Veröffentlicht in:	Stem cell research 2010-11, Vol.5 (3), p.226-243
Hauptverfasser:	Dobbin, E., Graham, C., Freeburn, R.W., Unwin, R.D., Griffiths, J.R., Pierce, A., Whetton, A.D., Wheadon, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ETS Translocation Variant 6 Protein Interferon Regulatory Factors - metabolism Interferon-gamma - metabolism Mass Spectrometry Mice Myelopoiesis Proteome - analysis Proto-Oncogene Proteins c-ets - metabolism Receptor, Platelet-Derived Growth Factor beta - metabolism Repressor Proteins - metabolism Signal Transduction STAT1 Transcription Factor - metabolism Stem Cells - metabolism Up-Regulation
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