Extensively drug-resistant Acinetobacter baumannii : risk factors for acquisition and prevalent OXA-type carbapenemases—a multicentre study
Abstract In this study, we investigated the risk factors for and carbapenem resistance mechanisms of extensively drug-resistant Acinetobacter baumannii (XDR-AB). Isolates of XDR-AB were collected from seven tertiary care hospitals in South Korea. A case–control study for risk factor analysis was per...
Gespeichert in:
| Veröffentlicht in: | International journal of antimicrobial agents 2010-11, Vol.36 (5), p.430-435 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 435 |
|---|---|
| container_issue | 5 |
| container_start_page | 430 |
| container_title | International journal of antimicrobial agents |
| container_volume | 36 |
| creator | Park, Yoon Soo Lee, Hyukmin Lee, Kkot Sil Hwang, Seung Sik Cho, Yong Kyun Kim, Hyo Youl Uh, Young Chin, Bum Sik Han, Sang Hoon Jeong, Seok Hoon Lee, Kyungwon Kim, June Myung |
| description | Abstract In this study, we investigated the risk factors for and carbapenem resistance mechanisms of extensively drug-resistant Acinetobacter baumannii (XDR-AB). Isolates of XDR-AB were collected from seven tertiary care hospitals in South Korea. A case–control study for risk factor analysis was performed and the presence of the metallo-β-lactamase (MBL) and OXA genes was examined. The control group consisted of adult inpatients receiving care from the same hospital. XDR-AB were isolated from 26 patients who were studied for risk factor analysis. Third-generation cephalosporin use [odds ratio (OR) = 9.6, 95% confidence interval (CI) 1.3–171.3; P = 0.02] and Acute Physiology and Chronic Health Evaluation (APACHE) II score (OR = 1.2, 95% CI 1.1–1.5; P = 0.004) were identified as risk factors for acquisition of XDR-AB. Pulsed-field gel electrophoresis (PFGE) showed clonal epidemic isolates in hospitals. MBLs were not detected, and all 30 XDR-AB isolates had upregulated OXA-type carbapenemase genes. These results suggest that third-generation cephalosporin use and disease severity are associated with XDR-AB acquisition amongst typical adult inpatients. This study also points to intrahospital spread of XDR-AB. Upregulated OXA-type carbapenemases are prevalent in XDR-AB founded in South Korean hospitals. |
| doi_str_mv | 10.1016/j.ijantimicag.2010.06.049 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_757463504</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0924857910003365</els_id><sourcerecordid>757463504</sourcerecordid><originalsourceid>FETCH-LOGICAL-c461t-c461670ac5877daf2a4937ddc5ee9f6b1f18f7913c5491bd01202bdd1adbc0ed3</originalsourceid><addsrcrecordid>eNqNks-O0zAQxiMEYsvCKyBzQJxS7DhxEg5IVbX8kVbaAyBxsyb2ZOVu4nQ9TrW98QLceEKeBJeWP-LEZSyNfvON9X2TZc8EXwou1MvN0m3ARzc6A9fLgqc-V0tetveyhWjqIq9bIe9nC94WZd5UdXuWPSLacC4qWVYPs7OCN6qUollkXy_uInpyOxz2zIb5Og9IjmKSZyvjPMapAxMxsA7mEbx3jr1iwdEN61N_CsT6KTAwt7MjF93kGXjLtgF3MGASufq8yuN-i8xA6GCLHkcgpO9fvgEb5yE6k6iAjOJs94-zBz0MhE9O73n26c3Fx_W7_PLq7fv16jI3pRLxZ1U1B1M1dW2hL6BsZW2tqRDbXnWiF01_8MBUZSs6y0XBi85aAbYzHK08z14cdbdhup2Roh4dGRwG8DjNpOuqLpWseJnI9kiaMBEF7PU2uBHCXguuD2Hojf4rDH0IQ3OlUxhp9ulpy9yNaH9P_nI_Ac9PAJCBoQ_gjaM_nJSV4pVK3PrIYfJk5zBoMg69QesCmqjt5P7rO6__UTGD8wkbbnCPtJnm4JPpWmgqNNcfDtdzOB7BOZdSVfIHzrPILg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>757463504</pqid></control><display><type>article</type><title>Extensively drug-resistant Acinetobacter baumannii : risk factors for acquisition and prevalent OXA-type carbapenemases—a multicentre study</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Park, Yoon Soo ; Lee, Hyukmin ; Lee, Kkot Sil ; Hwang, Seung Sik ; Cho, Yong Kyun ; Kim, Hyo Youl ; Uh, Young ; Chin, Bum Sik ; Han, Sang Hoon ; Jeong, Seok Hoon ; Lee, Kyungwon ; Kim, June Myung</creator><creatorcontrib>Park, Yoon Soo ; Lee, Hyukmin ; Lee, Kkot Sil ; Hwang, Seung Sik ; Cho, Yong Kyun ; Kim, Hyo Youl ; Uh, Young ; Chin, Bum Sik ; Han, Sang Hoon ; Jeong, Seok Hoon ; Lee, Kyungwon ; Kim, June Myung</creatorcontrib><description>Abstract In this study, we investigated the risk factors for and carbapenem resistance mechanisms of extensively drug-resistant Acinetobacter baumannii (XDR-AB). Isolates of XDR-AB were collected from seven tertiary care hospitals in South Korea. A case–control study for risk factor analysis was performed and the presence of the metallo-β-lactamase (MBL) and OXA genes was examined. The control group consisted of adult inpatients receiving care from the same hospital. XDR-AB were isolated from 26 patients who were studied for risk factor analysis. Third-generation cephalosporin use [odds ratio (OR) = 9.6, 95% confidence interval (CI) 1.3–171.3; P = 0.02] and Acute Physiology and Chronic Health Evaluation (APACHE) II score (OR = 1.2, 95% CI 1.1–1.5; P = 0.004) were identified as risk factors for acquisition of XDR-AB. Pulsed-field gel electrophoresis (PFGE) showed clonal epidemic isolates in hospitals. MBLs were not detected, and all 30 XDR-AB isolates had upregulated OXA-type carbapenemase genes. These results suggest that third-generation cephalosporin use and disease severity are associated with XDR-AB acquisition amongst typical adult inpatients. This study also points to intrahospital spread of XDR-AB. Upregulated OXA-type carbapenemases are prevalent in XDR-AB founded in South Korean hospitals.</description><identifier>ISSN: 0924-8579</identifier><identifier>EISSN: 1872-7913</identifier><identifier>DOI: 10.1016/j.ijantimicag.2010.06.049</identifier><identifier>PMID: 20864318</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Acinetobacter baumannii ; Acinetobacter baumannii - classification ; Acinetobacter baumannii - drug effects ; Acinetobacter baumannii - enzymology ; Acinetobacter baumannii - genetics ; Acinetobacter Infections - epidemiology ; Acinetobacter Infections - microbiology ; Acinetobacter Infections - pathology ; Adult ; Aged ; Anti-Bacterial Agents - pharmacology ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Bacterial Proteins - biosynthesis ; Bacterial Typing Techniques ; beta-Lactam Resistance ; beta-Lactamases - biosynthesis ; Biological and medical sciences ; Case-Control Studies ; Cross Infection - epidemiology ; Cross Infection - microbiology ; Cross Infection - pathology ; DNA Fingerprinting ; Electrophoresis, Gel, Pulsed-Field ; Extensive drug resistance ; Female ; Genotype ; Hospitals ; Humans ; Infectious Disease ; Male ; Medical sciences ; Middle Aged ; OXA carbapenemase ; Pharmacology. Drug treatments ; Republic of Korea - epidemiology ; Risk factor ; Risk Factors ; Severity of Illness Index</subject><ispartof>International journal of antimicrobial agents, 2010-11, Vol.36 (5), p.430-435</ispartof><rights>Elsevier B.V. and the International Society of Chemotherapy</rights><rights>2010 Elsevier B.V. and the International Society of Chemotherapy</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-c461670ac5877daf2a4937ddc5ee9f6b1f18f7913c5491bd01202bdd1adbc0ed3</citedby><cites>FETCH-LOGICAL-c461t-c461670ac5877daf2a4937ddc5ee9f6b1f18f7913c5491bd01202bdd1adbc0ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0924857910003365$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23356056$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20864318$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Yoon Soo</creatorcontrib><creatorcontrib>Lee, Hyukmin</creatorcontrib><creatorcontrib>Lee, Kkot Sil</creatorcontrib><creatorcontrib>Hwang, Seung Sik</creatorcontrib><creatorcontrib>Cho, Yong Kyun</creatorcontrib><creatorcontrib>Kim, Hyo Youl</creatorcontrib><creatorcontrib>Uh, Young</creatorcontrib><creatorcontrib>Chin, Bum Sik</creatorcontrib><creatorcontrib>Han, Sang Hoon</creatorcontrib><creatorcontrib>Jeong, Seok Hoon</creatorcontrib><creatorcontrib>Lee, Kyungwon</creatorcontrib><creatorcontrib>Kim, June Myung</creatorcontrib><title>Extensively drug-resistant Acinetobacter baumannii : risk factors for acquisition and prevalent OXA-type carbapenemases—a multicentre study</title><title>International journal of antimicrobial agents</title><addtitle>Int J Antimicrob Agents</addtitle><description>Abstract In this study, we investigated the risk factors for and carbapenem resistance mechanisms of extensively drug-resistant Acinetobacter baumannii (XDR-AB). Isolates of XDR-AB were collected from seven tertiary care hospitals in South Korea. A case–control study for risk factor analysis was performed and the presence of the metallo-β-lactamase (MBL) and OXA genes was examined. The control group consisted of adult inpatients receiving care from the same hospital. XDR-AB were isolated from 26 patients who were studied for risk factor analysis. Third-generation cephalosporin use [odds ratio (OR) = 9.6, 95% confidence interval (CI) 1.3–171.3; P = 0.02] and Acute Physiology and Chronic Health Evaluation (APACHE) II score (OR = 1.2, 95% CI 1.1–1.5; P = 0.004) were identified as risk factors for acquisition of XDR-AB. Pulsed-field gel electrophoresis (PFGE) showed clonal epidemic isolates in hospitals. MBLs were not detected, and all 30 XDR-AB isolates had upregulated OXA-type carbapenemase genes. These results suggest that third-generation cephalosporin use and disease severity are associated with XDR-AB acquisition amongst typical adult inpatients. This study also points to intrahospital spread of XDR-AB. Upregulated OXA-type carbapenemases are prevalent in XDR-AB founded in South Korean hospitals.</description><subject>Acinetobacter baumannii</subject><subject>Acinetobacter baumannii - classification</subject><subject>Acinetobacter baumannii - drug effects</subject><subject>Acinetobacter baumannii - enzymology</subject><subject>Acinetobacter baumannii - genetics</subject><subject>Acinetobacter Infections - epidemiology</subject><subject>Acinetobacter Infections - microbiology</subject><subject>Acinetobacter Infections - pathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Bacterial Proteins - biosynthesis</subject><subject>Bacterial Typing Techniques</subject><subject>beta-Lactam Resistance</subject><subject>beta-Lactamases - biosynthesis</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Cross Infection - epidemiology</subject><subject>Cross Infection - microbiology</subject><subject>Cross Infection - pathology</subject><subject>DNA Fingerprinting</subject><subject>Electrophoresis, Gel, Pulsed-Field</subject><subject>Extensive drug resistance</subject><subject>Female</subject><subject>Genotype</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infectious Disease</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>OXA carbapenemase</subject><subject>Pharmacology. Drug treatments</subject><subject>Republic of Korea - epidemiology</subject><subject>Risk factor</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><issn>0924-8579</issn><issn>1872-7913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks-O0zAQxiMEYsvCKyBzQJxS7DhxEg5IVbX8kVbaAyBxsyb2ZOVu4nQ9TrW98QLceEKeBJeWP-LEZSyNfvON9X2TZc8EXwou1MvN0m3ARzc6A9fLgqc-V0tetveyhWjqIq9bIe9nC94WZd5UdXuWPSLacC4qWVYPs7OCN6qUollkXy_uInpyOxz2zIb5Og9IjmKSZyvjPMapAxMxsA7mEbx3jr1iwdEN61N_CsT6KTAwt7MjF93kGXjLtgF3MGASufq8yuN-i8xA6GCLHkcgpO9fvgEb5yE6k6iAjOJs94-zBz0MhE9O73n26c3Fx_W7_PLq7fv16jI3pRLxZ1U1B1M1dW2hL6BsZW2tqRDbXnWiF01_8MBUZSs6y0XBi85aAbYzHK08z14cdbdhup2Roh4dGRwG8DjNpOuqLpWseJnI9kiaMBEF7PU2uBHCXguuD2Hojf4rDH0IQ3OlUxhp9ulpy9yNaH9P_nI_Ac9PAJCBoQ_gjaM_nJSV4pVK3PrIYfJk5zBoMg69QesCmqjt5P7rO6__UTGD8wkbbnCPtJnm4JPpWmgqNNcfDtdzOB7BOZdSVfIHzrPILg</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>Park, Yoon Soo</creator><creator>Lee, Hyukmin</creator><creator>Lee, Kkot Sil</creator><creator>Hwang, Seung Sik</creator><creator>Cho, Yong Kyun</creator><creator>Kim, Hyo Youl</creator><creator>Uh, Young</creator><creator>Chin, Bum Sik</creator><creator>Han, Sang Hoon</creator><creator>Jeong, Seok Hoon</creator><creator>Lee, Kyungwon</creator><creator>Kim, June Myung</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20101101</creationdate><title>Extensively drug-resistant Acinetobacter baumannii : risk factors for acquisition and prevalent OXA-type carbapenemases—a multicentre study</title><author>Park, Yoon Soo ; Lee, Hyukmin ; Lee, Kkot Sil ; Hwang, Seung Sik ; Cho, Yong Kyun ; Kim, Hyo Youl ; Uh, Young ; Chin, Bum Sik ; Han, Sang Hoon ; Jeong, Seok Hoon ; Lee, Kyungwon ; Kim, June Myung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-c461670ac5877daf2a4937ddc5ee9f6b1f18f7913c5491bd01202bdd1adbc0ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Acinetobacter baumannii</topic><topic>Acinetobacter baumannii - classification</topic><topic>Acinetobacter baumannii - drug effects</topic><topic>Acinetobacter baumannii - enzymology</topic><topic>Acinetobacter baumannii - genetics</topic><topic>Acinetobacter Infections - epidemiology</topic><topic>Acinetobacter Infections - microbiology</topic><topic>Acinetobacter Infections - pathology</topic><topic>Adult</topic><topic>Aged</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Bacterial Proteins - biosynthesis</topic><topic>Bacterial Typing Techniques</topic><topic>beta-Lactam Resistance</topic><topic>beta-Lactamases - biosynthesis</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Cross Infection - epidemiology</topic><topic>Cross Infection - microbiology</topic><topic>Cross Infection - pathology</topic><topic>DNA Fingerprinting</topic><topic>Electrophoresis, Gel, Pulsed-Field</topic><topic>Extensive drug resistance</topic><topic>Female</topic><topic>Genotype</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infectious Disease</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>OXA carbapenemase</topic><topic>Pharmacology. Drug treatments</topic><topic>Republic of Korea - epidemiology</topic><topic>Risk factor</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Yoon Soo</creatorcontrib><creatorcontrib>Lee, Hyukmin</creatorcontrib><creatorcontrib>Lee, Kkot Sil</creatorcontrib><creatorcontrib>Hwang, Seung Sik</creatorcontrib><creatorcontrib>Cho, Yong Kyun</creatorcontrib><creatorcontrib>Kim, Hyo Youl</creatorcontrib><creatorcontrib>Uh, Young</creatorcontrib><creatorcontrib>Chin, Bum Sik</creatorcontrib><creatorcontrib>Han, Sang Hoon</creatorcontrib><creatorcontrib>Jeong, Seok Hoon</creatorcontrib><creatorcontrib>Lee, Kyungwon</creatorcontrib><creatorcontrib>Kim, June Myung</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of antimicrobial agents</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Yoon Soo</au><au>Lee, Hyukmin</au><au>Lee, Kkot Sil</au><au>Hwang, Seung Sik</au><au>Cho, Yong Kyun</au><au>Kim, Hyo Youl</au><au>Uh, Young</au><au>Chin, Bum Sik</au><au>Han, Sang Hoon</au><au>Jeong, Seok Hoon</au><au>Lee, Kyungwon</au><au>Kim, June Myung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Extensively drug-resistant Acinetobacter baumannii : risk factors for acquisition and prevalent OXA-type carbapenemases—a multicentre study</atitle><jtitle>International journal of antimicrobial agents</jtitle><addtitle>Int J Antimicrob Agents</addtitle><date>2010-11-01</date><risdate>2010</risdate><volume>36</volume><issue>5</issue><spage>430</spage><epage>435</epage><pages>430-435</pages><issn>0924-8579</issn><eissn>1872-7913</eissn><abstract>Abstract In this study, we investigated the risk factors for and carbapenem resistance mechanisms of extensively drug-resistant Acinetobacter baumannii (XDR-AB). Isolates of XDR-AB were collected from seven tertiary care hospitals in South Korea. A case–control study for risk factor analysis was performed and the presence of the metallo-β-lactamase (MBL) and OXA genes was examined. The control group consisted of adult inpatients receiving care from the same hospital. XDR-AB were isolated from 26 patients who were studied for risk factor analysis. Third-generation cephalosporin use [odds ratio (OR) = 9.6, 95% confidence interval (CI) 1.3–171.3; P = 0.02] and Acute Physiology and Chronic Health Evaluation (APACHE) II score (OR = 1.2, 95% CI 1.1–1.5; P = 0.004) were identified as risk factors for acquisition of XDR-AB. Pulsed-field gel electrophoresis (PFGE) showed clonal epidemic isolates in hospitals. MBLs were not detected, and all 30 XDR-AB isolates had upregulated OXA-type carbapenemase genes. These results suggest that third-generation cephalosporin use and disease severity are associated with XDR-AB acquisition amongst typical adult inpatients. This study also points to intrahospital spread of XDR-AB. Upregulated OXA-type carbapenemases are prevalent in XDR-AB founded in South Korean hospitals.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>20864318</pmid><doi>10.1016/j.ijantimicag.2010.06.049</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0924-8579 |
| ispartof | International journal of antimicrobial agents, 2010-11, Vol.36 (5), p.430-435 |
| issn | 0924-8579 1872-7913 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_757463504 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acinetobacter baumannii Acinetobacter baumannii - classification Acinetobacter baumannii - drug effects Acinetobacter baumannii - enzymology Acinetobacter baumannii - genetics Acinetobacter Infections - epidemiology Acinetobacter Infections - microbiology Acinetobacter Infections - pathology Adult Aged Anti-Bacterial Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Bacterial Proteins - biosynthesis Bacterial Typing Techniques beta-Lactam Resistance beta-Lactamases - biosynthesis Biological and medical sciences Case-Control Studies Cross Infection - epidemiology Cross Infection - microbiology Cross Infection - pathology DNA Fingerprinting Electrophoresis, Gel, Pulsed-Field Extensive drug resistance Female Genotype Hospitals Humans Infectious Disease Male Medical sciences Middle Aged OXA carbapenemase Pharmacology. Drug treatments Republic of Korea - epidemiology Risk factor Risk Factors Severity of Illness Index |
| title | Extensively drug-resistant Acinetobacter baumannii : risk factors for acquisition and prevalent OXA-type carbapenemases—a multicentre study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T01%3A15%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Extensively%20drug-resistant%20Acinetobacter%20baumannii%20:%20risk%20factors%20for%20acquisition%20and%20prevalent%20OXA-type%20carbapenemases%E2%80%94a%20multicentre%20study&rft.jtitle=International%20journal%20of%20antimicrobial%20agents&rft.au=Park,%20Yoon%20Soo&rft.date=2010-11-01&rft.volume=36&rft.issue=5&rft.spage=430&rft.epage=435&rft.pages=430-435&rft.issn=0924-8579&rft.eissn=1872-7913&rft_id=info:doi/10.1016/j.ijantimicag.2010.06.049&rft_dat=%3Cproquest_cross%3E757463504%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=757463504&rft_id=info:pmid/20864318&rft_els_id=1_s2_0_S0924857910003365&rfr_iscdi=true |